P177 - Do Osteochondral Allograft (OCA) Donor Characteristics Impact Survivorship?
- W. Bugbee (La Jolla, US)
- W. Bugbee (La Jolla, US)
- D. Crawford (Portland, US)
- J. McCauley (La Jolla, US)
- S. Tabbaa (Flagstaff, US)
Abstract
Purpose
The impact of donor characteristics on clinical outcomes of OCA transplantation is not well understood. Several studies have reported inconsistent findings when considering storage time for fresh OCA grafts on clinical outcomes. No studies to date have investigated the possibility of donor characteristics impacting clinical outcomes. The purpose of this study was to determine if donor characteristics and graft storage time were associated with graft survivorship.
Methods and Materials
In this cohort study, data were analyzed from patients who underwent primary OCA transplantation of the knee (Table 1). All patients had a minimum 2-year follow-up. Survival rate (grafts remaining in situ) and survivorship were compared between patients who received OCA graft from donors (i) aged > 20 years old or ≤ 20 years old, (ii) with BMI ≤ 30 or with BMI > 30, (iii) of same sex (matched) or different sex (mismatched), (iv) released early (1-14d) or late (15-28d) using chi-square testing and log-rank analysis.
Results
The mean follow-up was 8.0 years. Patients who received OCA grafts from older donors had a significantly lower survival rate of 88.3% (grafts remaining in situ) compared to OCAs from younger donors (96.7%, P = 0.039). The 10-year survivorship (Figure 1) of the OCA was 89.3% for older donor group and 100.0% for younger donor group. Interestingly, OCA survival rate for early release (77.3%) was significantly lower than late-release (94.0%) group (P = 0.002). The 10-year survivorship rate was 85.6% in the early-release and 96.1% in the late-release group. Donor BMI and sex matching did not impact survivorship.
Conclusion
Donor factors are important variables that have not been previously studied. The findings of this work suggest that donor age can impact survivorship of OCA transplantation. Late-release grafts were also associated with higher graft survivorship.