Introduction

Among osteo-articular diseases, osteoarthritis (OA) is the most common arthropathy whose incidence increases with population ageing, obesity, genetic factors or following traumas. Rheumatoid arthritis (RA) is the second leading cause of disability.

Content

Although both diseases result in articular cartilage degradation, RA is a highly inflammatory disease characterized by the presence of an invading inflammatory pannus in joints while OA is characterized by low grade chronic inflammation together with sub-chondral bone alterations. Current treatments are either symptomatic to relieve pain or anti-inflammatory using immunosuppressive drugs including biotherapies in case of RA. However, no curative therapeutic options can be provided to patients. In this context, the therapeutic effect of mesenchymal stem cells, also known as mesenchymal progenitor or stromal cells (MSC), has been investigated. MSC display regenerative and repair activities through the secretion of many trophic paracrine factors that can influence joint repair (1). Recent data suggest that most of the secreted factors released by MSC are conveyed within extracellular vesicles (EV) that reproduce the main function of the parental cells. Indeed, the use of EV instead of MSC might be an attractive alternative for rheumatic diseases. We will present in vitro and non-clinical data using MSC-derived EV in the murine models of inflammatory arthritis and of OA (2-3). Perspectives for the use of MSC-EV in rheumatology will be discussed.

References

References:

Cosenza S, Ruiz M, Maumus M, Jorgensen C, Noël D. Pathogenic or therapeutic extracellular vesicles in rheumatic diseases: role of mesenchymal stem cell-derived vesicles. Int J Mol Sci, 2017: 18:889-904

Cosenza S, Ruiz M, Toupet K, Jorgensen C, Noël D. Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Scientific reports, 2017, 7:16214

Cosenza S, Toupet K, Maumus M, Luz-Crawford P, Blanc-Brude O, Jorgensen C, Noël D. Mesenchymal stem cells derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Theranostics 2018, 8:1399-1410