R. Akagi (Chiba, JP)
Graduate school of medicine, Chiba University Orthopaedic SurgeryPresenter Of 1 Presentation
10.1.9 - The short-term outcomes of autologous chondrocyte implantation associated with an atelocollagen-based scaffold
Abstract
Purpose
To evaluate the short-term outcomes of autologous chondrocyte implantation (ACI) associated with an atelocollagen-based scaffold against cartilage injuries in the knee joint.
Methods and Materials
All patients who received implantation of the atelocollagen-based scaffold ACI were included in the registry of a multicenter study conducted by six institutions. Patient demographics (age, sex and the total size of injured cartilage lesions) and clinical outcomes evaluated by Knee Osteoarthritis and injury Outcome Score (KOOS) and Lysholm score were prospectively collected before surgery and at six and 12 months after surgery. Clinical outcomes were compared between three age categories (I: 15-29 years, II: 30-44 years, III: 45-59 years) and by the size of the defect. Magnetic resonance imaging (MRI) exam was performed at six and 12 months after implantation, and the morphology and quality of the repaired tissue were assessed with magnetic resonance observation of cartilage repair tissue (MOCART) evaluation and quantitative analysis of T2 mapping. Only patients who were followed for at least one year after surgery were included for analysis in the current study.
Results
Twenty-six patients (14 males, 12 females, mean age 41.0 years old) were included in the study. All KOOS scores for symptom, pain, activities in daily living, sports, and quality of life, as well as Lysholm score, showed improvement at one year after surgery. There was no significant difference in improvement of clinical outcomes between any age categories, and between large or small cartilage defects. The MRI evaluation revealed improvement in the morphology and quality assessed by parameters such as defect filling and tissue signal intensity, but subchondral bone degeneration tends to progress one year after the implantation.
Conclusion
The overall short-term clinical outcomes after ACI associated with atelocollagen-based scaffold were favorable regardless of patient age or the size of the cartilage defect. Improvement of the implanted tissue was confirmed by MRI.