P029 - Behavior of Osteoarthritis markers in patients with Anterior Cruciate Ligament Reconstruction at 24-months
Abstract
Purpose
To compare the levels in blood and urine of OA Biomarkers in (CTx-II & MMP-3) in patients with ACL-R alone or associated with cartilage lesions at 24-months
Methods and Materials
Prospective Controlled Randomized Study with 40 patients included (16-45 years), BMI<30, well alignment. Before ACL-R a sample of blood and urine was taken in every patient to be processed by ELISA in order to determine the u-CTx-II and s-MMP-3, those measures were repeated at 24-months.
Results
A total of 40 subjets; Twenty male patients (67.5%) vs 13 female (32.5%) with a mean age of 26.05 +/-8.05 years. Meniscal lesion was observed in 85% of the cases (MM=60% vs LM=40%) while cartilage lesions was presented in 35% of cases (ICRS<2=7, ICRS-2=7). Both biomarkers (BM) increased significantly at 24-m (CTx-II= 4.24+/-3.1 vs 61.4+/-53.2, p=0.0001; MMP-3= 1.92+/-5.2 vs 2.95+/-0.7, p=0.26). No significant difference between ICRS grade of lesion in global evaluation but there is a significant increase of CTx-II in females with cartilage lesions ICRS>2. In MMP-3 no gender differences were observed.
Conclusion
The presence of Cartilage lesions ICRS>2 associated with ACL-R and male gender are a risk factor for CTx-II increasing and probably to a higher risk of OA.
