Presenter of 1 Presentation
ENGINEERING DESIGN AND PERFORMANCE VERIFICATION OF THE 10 MV FLASH IRRADIATION STATION AT TRIUMF
Abstract
Background and Aims
Access to robust high-energy sources of ultrahigh dose-rate x-rays for FLASH research remains severely limited. To help fill this unmet need, a FLASH-capable small-animal irradiation station is being developed around a 1kW, 10MeV electron-to-photon converter on the ARIEL e-linac at TRIUMF (Figure1).
Methods
Development of the ARIEL FLASH electron-to-photon converter has been predicated on achieving specific performance thresholds. Monte Carlo (MC) simulations (FLUKA,EGSnrc) of a water-cooled tantalum-aluminum target were performed to maximize dose-rates, evaluate activation and meet shielding requirements. Finite-element-analysis (ANSYS) simulations facilitated thermo-mechanical optimization of the target to withstand both continuous and pulsed beam irradiations for several months (Figure 1c). Offline tests are being performed to validate thermal and water erosion behavior using an arc-welding torch which provides a kilowatt heat source to replicate the thermal conditions found under e-beam irradiation.
Results
The simulated dose-rate to lung in a realistic mouse phantom is 85±3Gy/s for 10MV photons at 1kW (Figure 2). These results will be validated through film dosimetry in realistic 3D-printed mouse phantoms. Results of thermal benchmarking and stress-testing beyond threshold specifications will confirm the design robustness of the target, which has been optimized to withstand frequent thermal cycling and the resulting fatigue.
Conclusions
An ultrahigh dose-rate 10 MV x-ray source has been successfully designed for the FLASH irradiation station at the ARIEL e-linac. The experimental end-station will facilitate reproducible delivery of high-dose, single fractions to small-animal models once testing and beam characterization are completed ahead of planned treatments in Fall 2021.
Author Of 1 Presentation
ENGINEERING DESIGN AND PERFORMANCE VERIFICATION OF THE 10 MV FLASH IRRADIATION STATION AT TRIUMF
Abstract
Background and Aims
Access to robust high-energy sources of ultrahigh dose-rate x-rays for FLASH research remains severely limited. To help fill this unmet need, a FLASH-capable small-animal irradiation station is being developed around a 1kW, 10MeV electron-to-photon converter on the ARIEL e-linac at TRIUMF (Figure1).
Methods
Development of the ARIEL FLASH electron-to-photon converter has been predicated on achieving specific performance thresholds. Monte Carlo (MC) simulations (FLUKA,EGSnrc) of a water-cooled tantalum-aluminum target were performed to maximize dose-rates, evaluate activation and meet shielding requirements. Finite-element-analysis (ANSYS) simulations facilitated thermo-mechanical optimization of the target to withstand both continuous and pulsed beam irradiations for several months (Figure 1c). Offline tests are being performed to validate thermal and water erosion behavior using an arc-welding torch which provides a kilowatt heat source to replicate the thermal conditions found under e-beam irradiation.
Results
The simulated dose-rate to lung in a realistic mouse phantom is 85±3Gy/s for 10MV photons at 1kW (Figure 2). These results will be validated through film dosimetry in realistic 3D-printed mouse phantoms. Results of thermal benchmarking and stress-testing beyond threshold specifications will confirm the design robustness of the target, which has been optimized to withstand frequent thermal cycling and the resulting fatigue.
Conclusions
An ultrahigh dose-rate 10 MV x-ray source has been successfully designed for the FLASH irradiation station at the ARIEL e-linac. The experimental end-station will facilitate reproducible delivery of high-dose, single fractions to small-animal models once testing and beam characterization are completed ahead of planned treatments in Fall 2021.