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Browsing Over 277 Presentations
Electon Beams, Stars of FLASH Radiotherapy (ID 355)
A re-emergence of research implementing radiation delivery at ultra-high dose rates (UHDR) has triggered intense interest in the radiation sciences and has opened a new field of investigation in radiobiology. Much of the promise of UHDR irradiation involves the FLASH effect, an in vivo biological response observed to maintain anti-tumor efficacy without the normal tissue complications associated with standard dose rates. The FLASH effect has been validated primarily, using intermediate energy electron beams able to deliver high doses in a very short period of time (<200 ms), but has also been found with photon and proton beams. The clinical implications of this new area of research are highly significant, as FLASH radiotherapy (FLASH-RT) has the potential to enhance the therapeutic index, opening new possibilities for eradicating radio-resistant tumors without toxicity. As pioneers in this field, my group has developed a multidisciplinary research team focused on investigating the mechanisms and clinical translation of the FLASH effect. I will tell the story of the recent discovery of the FLASH effect and will review the recent results obtained with electron beams at ultra-high dose rate.