Tobias Moser, Göttingen, Germany

University Medical Center Göttingen Institute for Auditory Neuroscience

Presenter Of 2 Presentations

Technical Workshop

Towards the Optical Cochlear Implant: Optogenetic Stimulation of the Auditory Pathway (ID 773)

Lecture Time
10:43 - 11:08

Abstract

Abstract Body

When hearing fails, cochlear implants (CIs) provide open speech perception to most of the currently half a million CI users. CIs bypass the defective sensory organ and stimulate the auditory nerve electrically. The major bottleneck of current CIs is the poor coding of spectral information, which results from wide current spread from each electrode contact. As light can be more conveniently confined, optical stimulation of the auditory nerve presents a promising perspective for a fundamental advance of CIs. Moreover, given the improved frequency resolution of optical excitation and its versatility for arbitrary stimulation patterns the approach also bears potential for auditory research. Developing optogenetic stimulation for auditory research and future CIs requires efforts toward design and characterization of appropriate optogenetic actuators, viral gene transfer to the neurons, as well as engineering of multichannel optical CIs. The presentation will summarize the current state of optogenetic stimulation of the auditory pathway and report on recent breakthroughs on achieving high temporal fidelity and frequency resolution and establishing multichannel optical CIs.

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Moderator Of 1 Session

11.07.2020, Saturday 09:00 - 11:30 Hall I Technical Workshop
Date
11.07.2020, Saturday
Session Time
09:00 - 11:30
Session Description
Optogenetics is a highly active and interdisciplinary field of research with major relevance to the broad neuroscience community. Optogenetics enables cell-type- and brain area-specific, spatially confined and graded stimulation and inhibition of neurons. Optogenetics ranges from tool making to applications in clinical neurosciences. Insight into new optogenetic tools: tailored opsins and vectors (Boyden, Dalkara, Gradinaru, Moser) and light delivery approaches: structured illumination by spatial light modulators and implantable micro-LED arrays (Emiliani, Moser). Understanding neural circuitry using optogenetic manipulation (Boyden, Gradinaru, Emiliani). Restoring the function of neural circuitry by optogenetic stimulation (Boyden, Gradinaru, Dalkara, Moser). Selection of speakers covers leading experts with balanced representation of gender (50% female), age, and European nations, two transatlantic speakers

Author Of 2 Presentations

Technical Workshop

Towards the Optical Cochlear Implant: Optogenetic Stimulation of the Auditory Pathway (ID 773)

Lecture Time
10:43 - 11:08

Abstract

Abstract Body

When hearing fails, cochlear implants (CIs) provide open speech perception to most of the currently half a million CI users. CIs bypass the defective sensory organ and stimulate the auditory nerve electrically. The major bottleneck of current CIs is the poor coding of spectral information, which results from wide current spread from each electrode contact. As light can be more conveniently confined, optical stimulation of the auditory nerve presents a promising perspective for a fundamental advance of CIs. Moreover, given the improved frequency resolution of optical excitation and its versatility for arbitrary stimulation patterns the approach also bears potential for auditory research. Developing optogenetic stimulation for auditory research and future CIs requires efforts toward design and characterization of appropriate optogenetic actuators, viral gene transfer to the neurons, as well as engineering of multichannel optical CIs. The presentation will summarize the current state of optogenetic stimulation of the auditory pathway and report on recent breakthroughs on achieving high temporal fidelity and frequency resolution and establishing multichannel optical CIs.

Hide