Circuit Dynamics and Computational Neuroscience H.4.c Function and mechanisms Monday AM + Wednesday AM

2456 - Cardiorespiratory coupling is influenced by body position and slow paced 0.1Hz breathing in a state specific manner

Topic / Sub Topic
H.4.c Function and mechanisms
Availability:
Sunday 12th 10:30-12:00/14:30-16:00; Monday 13th 14:30-16:00; Tuesday 14th 10:30-12:00/14:30-16:00
My link to connect:
http://zoom.us/j/4466227679?pwd=RmdCTm5VcXpHU3hBU0laaHZxcnlhdz09

Abstract

Abstract Body

Introduction: Cardiorespiratory coupling (CRC) of cardiac and respiratory rhythms that optimise the body oxygenation and the adaptability of the cardiorespiratory system to the external and internal environment, is represented by coefficient Qpr, the number of heartbeats per respiratory cycle (1, 2). Slow 0.1Hz breathing in supine position (Supin01) and active standing (Stand) represent the states of maximal heart rate vagal and sympathetic modulation, respectively, in physiological quiescence; standing with 0.1Hz breathing (stand01) is characterized by qualitatively specific pattern of CRC(3).

The aim of our work was to investigate the Qpr in 4 states: supine position with spontaneous breathing (supin), stand, supin01and stand01.

Methods: The ECG (RRI) and respiration signals were simultaneously recorded in 20 healthy human subjects in four conditions. Data acquisition and processing detaily described in (3).

Results: Presented in Table 1 and 2.

Conclusion: Our results show that Qpr is state dependent and that it increases with the behavioral task complexity. Postural change tunes Qpr by RRI modulation, while 0.1Hz breathing dominantly by the increase of BBI. Stand01 is characterized by concomitant adjustment of both RRI and BBI. These data imply that Qpr regulation is "loosely" and selectively coordinated in stand and supin01("dual control") while integrated in stand01 ("unitary control"(4)). Analogously to nonlinear CRC(3), Qpr is probably operated by hierarchically higher diencephalo-telencephalic autonomic networks.

References:

1. Moser M et al, Biol Rhythm Res 1995;26(1):100.

2. Scholkmann F et al, Front Physiol 2019;10:371.

3. Matić Z et al, Front Physiol 2020;11:24.

4. Feldman JL et al, Annu Rev Physiol 1988;50,593–606.

tables 1 and 2 corr wilcoxon.jpg

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