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12.07.2020, Sunday 12:00 - 12:45 Hall B Special Lecture
12.07.2020, Sunday
Session Time
12:00 - 12:45

Partner introduction (ID 5496)

Introducer: Hailan Hu: IBRO - Kemali Prize Lecture (ID 5497)

From pecking order to Ketamine – Neural mechanisms of social and emotional behaviors (ID 1274)

Lecture Time
12:06 - 12:36


Abstract Body

I will present progresses on the interplay between winning history and activities of prefrontal circuit; the impact of social status loss on depression; and, how ketamine tames depression by blocking burst firing in an anti-reward center, involving a surprising role of glia.
Recommended reading:
1. Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, Hu H. (2018) Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature, 554: 317-22 (article)
2. Cui Y, Yang Y, Ni Z, Dong Y, Sang K, Cai G, Foncelle A, Ma S, Sang K, Tang S, Li Y, Shen Y, Berry H, Wu S, Hu H. (2018) Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression. Nature, 554: 323-27 (article)
3. Zhou TT, Zhu H, Fan ZX, Wang F, Chen Y, Liang HX, Yang ZF, Zhang L, Lin LN, Zhan Y, Wang Z, Hu H. (2017) History of winning remodels thalamo-PFC circuit to reinforce social dominance. Science. 357: 162-168. (article)
4. Li K, Zhou T, Liao L, Yang Z, Wong C, Henn F, Malinow R, Yates J, Hu H. (2013) βCaMKII in lateral habenula mediates core symptoms of depression. Science, 341:1016-1020.
5. Wang F, Zhu J, Zhu H, Zhang Q, Lin Z, Hu H (2011) Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science, 334: 693-697.