This symposium will present the latest advances in the study of neural circuits for somatosensation at both spinal and supraspinal levels. This topic is particularly timely, as we are just starting to dissect these circuits. Our speakers comprise a multinational group of researchers. Notably, this symposium will present results from different subfields of somatosensation (e.g. pain, itch, touch) and a range of techniques (electrophysiology, optogenetics, molecular genetics), in order to present the audience with state-of-the-art approaches to defining functional circuitry. We will report the study of spinal neural circuits underlying touch, and how local inhibitory neurons gate sensory feedback to the spinal motor system during walking (Bourane et al., Cell, 2015; Koch et al., Neuron, 2017). The functional diversity of the spinal neural circuits is complemented by the study of gating mechanisms for itch sensation (Bourane et al., Science, 2015; Ralvenius et al., Nat Commun. 2018; Pagani et al., Neuron, In press). We will also present functional studies on ascending pathways for itch and pain (Han et al., Cell, 2015; Mu et al., Science 2017). In addition, we will show the circuit mechanism underlying descending modulation of the spinal itch circuit (Gao et al., Neuron, 2019). These studies have dissected circuit mechanisms of both the sensory and emotional components of somatosensation, and will be of great interest to a broad scientific audience.