Browsing Over 29 Sessions
Day
  • 14.07.2020, Tuesday
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Plenary lecture
Room
Hall A
Date
14.07.2020, Tuesday
Session Time
08:30 - 09:30
Morning poster sessions

P05 - Morning Poster Sessions

Room
Poster Area
Date
14.07.2020, Tuesday
Session Time
09:00 - 13:15
Parallel Symposium
Room
Hall A
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
The cerebral cortex represents the largest brain area and consists of an extraordinary number and diversity of neurons and glial cells. Yet, how the cortex, with all its neuronal circuits, arises from the neural stem cells (NSCs) in the developing neuroepithelium is a major unsolved question. In our symposium we will focus on a key aspect of cortical development: what are the mechanisms in NSCs regulating the balance between proliferation and differentiation to specify the cerebral cortex of its correct size and composition? The specific objectives shall address 1) the principles of NSC lineage progression during cortical development; 2) the cellular and molecular mechanisms controlling neuron and glia output from NSCs; 3) how disruption of NSC behavior upon mutation of particular signaling pathways leads to cortical malformation and 4) how cell-intrinsic and niche-derived factors interact to regulate NSC behavior. We will present novel conceptual advances with the ultimate goal to synthesize a general framework how intrinsic programs in NSCs in combination with extrinsic niche components regulate neuron genesis within the neurogenic microenvironment. Altogether, the symposium will focus not only on the developmental mechanisms of corticogenesis, but also include aspects of molecular neuroscience, cell biology, and neurodevelopmental and psychiatric disease neuroscience. We are convinced that our symposium will thus be of interest to a broad audience of neuroscientists.
Parallel Symposium
Room
Hall B
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
New optogenetic, imaging and electrophysiology techniques available in rodents have made huge contributions to our understanding of how the brain represents sensory information. However, natural stimuli are invariably multisensory, creating complex signals that must be integrated across different modalities. Despite a wealth of human psychophysics and neural recordings from individual cells, we still have many outstanding questions about the circuit mechanisms underlying multisensory integration. An increasing number of groups are beginning to answer these questions using state-of-the-art techniques to record and manipulate large neural populations in rodents. Techniques such as targeted optogenetics can be used to modulate the activity of specific neuronal populations during behaviour or to unravel the connectivity across brain regions. Moreover, neural activity during complex multisensory tasks is being recorded with high-throughput electrophysiology in freely moving and head-fixed animals. The speakers are at the forefront of applying these techniques to interrogate and manipulate the mechanisms of multisensory integration at every scale, from microcircuits (Medini) and neural populations (Diamond) to brain regions (Coen) and behavioural states (Lee). They have revealed that facets of multisensory integration exist throughout the brain, from primary sensory regions, to more complex cognitive areas in frontal cortex.
Parallel Symposium
Room
Hall C
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
Behavioral mechanisms are defined by the function of underlying neural circuits. To understand the logic of circuit-level computations guiding behavior, it is necessary to define how the interactions between components of the circuitry are modulated to mediate behavioral outcomes. This symposium will bring together leading cellular neuroscientists from different countries aiming to provide insights into latest advances in understanding neuromodulatory mechanisms of behavioral control. In the first part of this symposium, Roger Clem will discuss contributions of GABA and somatostatin signaling to mnemonic functions of somatostatin interneurons in mPFC. Fear learning augments activity of these cells, and their activation is both necessary and sufficient for fear expression. Then, Ingrid Ehrlich will present results on functional roles of intercalated cell networks in fear learning and extinction, and modulation of these networks by dopaminergic inputs from midbrain areas. In the second part of the symposium, Christian Lüscher will provide evidence that strong activation of a positive reinforcement circuit, either by addictive drugs or via optogenetic stimulation, is sufficient to drive addictive behavior, leading to compulsion. Finally, Vadim Bolshakov will present results on how anxiety-related behavioral states are controlled by neuropeptides at the level of neural circuits in amygdala and BNST, inducing changes in functional interactions between their structural components.
Parallel Symposium
Room
Hall D
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
The hippocampus is critical for the formation of episodic memories, and we are just beginning to understand how the hippocampus forms associations between stimuli in both time and space. In this workshop, we will explore recent work on the formation of associations and memories in the human hippocampus. These studies use recordings of single-neuron activity in the hippocampus of epilepsy patients implanted with electrodes for clinical diagnostics. In our workshop, Rodrigo Quian Quiroga will first present how single neurons act in the dynamic formation of associations in the human hippocampus. Johannes Sarnthein will then present how persistent firing of single neurons in the medial temporal lobe is embedded in the cortical working memory network. Doris Dijksterhuis will describe how single cells in the hippocampus form rapid links between words in a sentence reading task. Finally, Florian Mormann will show how long-term memory of complex items is reflected in long-term recordings of concept cells in the hippocampus. The speakers will present an overview of their research with human single neurons in Europe with high scientific interest internationally. The recent data extend knowledge from animal experiments to the complex tasks amenable only in humans. The existing models of cognitive processing should be tested on these data and possibly adapted.
Parallel Symposium
Room
Hall E
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
Over the past years, an increasing body of work investigating the biology of RNA-protein interplay has shed novel insights into neuronal homeostasis and pathology while the unique biology of RNA-binding proteins (RBPs) and Stress granules (SGs) is altering our view of the genesis of protein misfolding diseases. While, stressed cells shut down translation, release mRNA from ribosomes, and form SGs that may cause neurodegeneration, the etiopathogenic relationship between these activities remains enigmatic. This symposium will present recent and unpublished (human- and animal-based) findings about the etiopathogenic implications of RBPs and SGs in a broad spectrum of neurological disorders such as Alzheimer and Parkinson’ diseases (AD & PD), Amyotrophic lateral sclerosis (ALS) and Stress-driven depression. Dr Alberti (Germany) will present novel evidence about a complex mechanism of phase separation of G3BP1, an RBP, that may cause SGs formation and neurodegeneration in ALS while Dr Kouroupi (Greece) will focus on the RBPs role in PD synaptic and axonal degeneration. Prof. Wolozin (USA) will present the essential role of TIA-1, another RBP, in the formation of SGs and its causal relationship to oligomerization and spreading of Tau pathology while Dr Sotiropoulos (Portugal) will describe the implication of RBPs and SGs into the mechanisms which lifetime (environmental) stress, a risk factor for AD, trigger autophagy inhibition and Tau aggregation precipitating brain pathology.
Parallel Symposium
Room
Hall F
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
Even for the same task, one rarely observes the exact same cortical response twice. Such variability is ubiquitous throughout the brain, and is observed at all spatial scales, from single synapse function to collective activity of entire brain areas. Is variability merely a result of unavoidable noise in the system, or is it harnessed and even enforced by the brain as an integral part of computation? Variability is a highly timely topic; its ubiquitous presence is becoming clearer than ever, thanks to the massively parallel data being recorded currently. At the same time, insight into variability is crucial for understanding the neural code that these data allow us to investigate with unprecedented detail. Typically, studies into variability either take a descriptive approach, quantifying what kind of factors reduce variability; or a constructive approach, deriving the significance of variability for brain function. In this workshop, we bring together the descriptive and constructive perspectives. Kenneth Harris and Timothy O’Leary will discuss the properties of variability in brain-wide population activity and smaller neural circuits; Anna Levina and Christian Machens will derive the benefits and detriments of variability for brain function. Our speakers are 50% junior and 25% female, and are from three European countries: Germany, Great Britain, and Portugal. Including the organizers, we comprise 67% junior and 50% female faculty representing four nationalities.
Parallel Symposium
Room
Hall G
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
The dentate gyrus (DG) is the entrance gate of the hippocampus and translates the rich input stream from the entorhinal cortex into sparse non-overlapping memories. The network mechanisms underlying sparse coding are however largely unknown. This symposium will highlight new insights on the role of the various cellular components of the DG network, glutamatergic granule cells (GCs) and GABAergic inhibitory interneurons in the sparse coding of information and the spatio-temporal emergence of DG population activity during learning. We will provide new insights on the relationship between the rich input stream from the lateral and medial entorhinal cortex to the DG and the sparse activity patterns of GC populations. Despite the important role of the DG as patterns separator allowing the discrimination between similar but distinct memories, we provide evidence that the DG is also involved in decision-making and planning. Finally, we provide evidence that representation of contextual information depends on the attentive state of the animal. We will present recently published and unpublished data obtained with state-of-the-art techniques including multiple single unit recordings of neuron types in behaving rodents, optophysiological manipulations of neuron types to test their role in cell assembly formation during learning and decision-making, as well as population imaging during learning in the virtual reality.
Parallel Symposium
Room
Hall H
Date
14.07.2020, Tuesday
Session Time
09:45 - 11:15
Session Description
Spontaneous network activity plays an essential role in the establishment of sensory circuits. At embryonic stages, spontaneous activity is highly synchronized and is mediated by electrical communication. Activity patterns gradually desynchronize postnatally as a consequence of the maturation of the electrical properties of the network. This symposium aims to compare and contrast the role of spontaneous activity during different developmental stages and across sensory systems. Anne Sinning will describe how spontaneous activity in developing cortical networks matures, its physiological role and the pathophysiological implications of its alteration. Guillermina López-Bendito will present recent findings demonstrating that spontaneous activity in the thalamus is fundamental for the emergence and plasticity of sensory maps already in the embryonic brain. Dwight Bergles will discuss the mechanisms controlling spontaneous activity in the postnatal developing auditory system, which is driven by periodic activity bursts in the cochlea before hearing onset. Marla Feller will conclude the symposium by showing that the interaction between spontaneous activity and early light responses in the retina helps refining visual circuits. Our goal is to not only highlight the specific functions of spontaneous activity during different phases of development, but also and in particular, discuss the common fundamental principles of early activity-dependent network development.
Special interest event

SiE16: Don't leave me now play

Room
Hall C
Date
14.07.2020, Tuesday
Session Time
12:30 - 13:30
Session Description
When Brian Daniels, the author of the play attended the 50th birthday party of his friends Irene Heron and Rachael Dixey, in 1997, he remembers it as a joyful and exuberant event. Nobody then could have guessed that ten years later the vivacious and theatrical Irene would be developing early onset dementia and fifteen years later she would have lost her functioning powers, be in a care home and she would die aged 66 in 2013. Her partner of 25 years, Professor Rachael Dixey wrote in her journal every day about the challenges of living with a partner who had dementia. She asked Brian to read the journal and he was then inspired by write a play about family life and early onset dementia. Irene was cared for in a nursing home in Yorkshire. In the same nursing home was Chris Toulman. Chris and his wife Cindy had been married for over 40 years and were a devoted couple. Chris had never had a good memory but warning bells started to sound when he started getting into a muddle when doing the accounts of his garage business. He would sometimes do the MOT twice on a car, forgetting he had already done the work. Eventually he was diagnosed with dementia and in time went into full time care. His wife visited him every day, and all day, talking to him, feeding him and loving him. Chris died in his early 60s. With the support of both families Brian embarked on writing these very personal stories. He wanted to explore through a play the way in which dementia impacts on the wider family and whether love ever becomes a duty. The first ‘shared’ performances of the play were at the West Yorkshire Playhouse, Leeds and the play has gone on to have to date (November 2017) more than 150 performances throughout the UK and Northern Ireland. The play has also been filmed by Birmingham NHS Trust to help educate around the complexities of the Mental Capacity Act.
Special interest event

SiE13 - Animal experimentation and the search for alternatives – current developments and future perspectives

Room
Hall A
Date
14.07.2020, Tuesday
Session Time
12:30 - 13:30
Session Description
The principles of replacement, refinement and reduction - the “Three Rs” put forward by the European Directive on the protection of animals used for scientific purposes - continue to shape scientific research across the EU and beyond. In this context, the search for alternatives to animal models increasingly influences the development of research projects. At the same time, the importance of employing the correct model - be that animal or otherwise - remains key to the reliability, and indeed utility, of any results. The discussion will cover situations involving a shift from high to low complexity models, from animal models to experiments in humans, and animal to in vitro models. Speakers who have made such changes will discuss their reasons for doing so, the challenges encountered and the impact on their working methods.