Browsing Over 130 Sessions

Legend
  • Parallel Symposium (16) (16)
  • Technical Workshop (1) (1)
  • Plenary lecture (2) (2)
  • Morning poster sessions (1) (1)
  • Special interest event (5) (5)
  • Afternoon poster sessions (1) (1)
  • Networking Event (1) (1)
  • Special Lecture (2) (2)
  • Award Ceremony (1) (1)
Poster Area
Hall A
Hall B
Hall C
Hall D
Hall E
Hall F
Hall G
Hall H
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  • Session Time
    08:30 - 09:30
    Session Type
    Plenary lecture
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    Neuronal specification and differentiation require precise spatiotemporal regulation of gene expression programs. How these programs are transcriptionally coordinated in progenitors and postmitotic neurons during development is poorly understood. Chromatin regulation may provide a mechanism to orchestrate transcriptional programs since environmental stimuli and neuronal activity can induce chromatin epigenetic changes. This symposium will focus on epigenetic and transcriptional regulation of neuronal development. D. Jabaudon will present single-cell RNA sequencing data to trace the lineage of mouse cortical apical progenitors (APs) and their daughter neurons. Moreover, he will discuss how the Polycomb chromatin repressor complex epigenetically regulates AP temporal progression into distinct postmitotic progenies of cortical neurons. A. Riccio will discuss the role of chromatin remodelling complex NuRD in mouse cortical development and how neurotrophins and nitric oxide regulate chromatin remodelling complex activity. S-nitrosylation of epigenetic factors will be also discussed. F. Rijli will discuss the recent identification of distinct Polycomb chromatin signatures regulating activity-dependent transcription in developing somatosensory neurons during whisker-related barrelette map formation. B. Treutlein will present single-cell genomics tools to study human brain development and discuss comparative transcriptomics between human, chimpanzee and macaque using brain organoids.
  • Session Time
    12:30 - 13:30
    Session Type
    Special interest event
    Session Description
    The most important skill a scientist needs, after the research and technical skills needed to execute a study, is the ability to report their scientific endeavours in the written form. Indeed, there is no point in conducting research if one cannot articulate new scientific knowledge. The aim of this workshop, which will be presented by the editors of four international, society-owned neuroscience journals, to discuss what happens to a paper once the ‘submit’ button is pressed. We will discuss what editors consider when deciding whether to review a paper, what we expect from reviewers, what we expect in a good paper, how journals expect data to be represented and statistical analyses reported and issues around journal metrics. Each of the editors will be attending the FENS forum and will be available for discussion about current papers, prospective papers and special issues. Additional aims are: • to stress the importance of Society-owned journals, • to show that we as editors are approachable and want to publish good science • to show that we are scientists ourselves who have gone through the submission process many times and • to dispel the idea of conflict between the author and Editors/reviewers
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    The aim of the symposium is to advance our understanding of the role of GABAergic inhibition in brain plasticity. The symposium has the following main objectives: 1. synthesise findings across species (mice, humans) on common inhibitory mechanisms that underlie learning and homeostatic plasticity 2. showcase state-of-the-art methods for measuring and manipulatng GABAergic inhibition in-vivo across species, including 2-photon imaging and chemogenetics in mice and MR Spectroscopy combined with tDCs in humans 3. present computational models that provide novel insights and predictions for the role of inhibitory circuits in plasticity 4. inform clinical translation to patient populations with disorders associated with inhibitory dysfunction (e.g. neurodevelopmental disorders). Levelt will present work employing 2-photon imaging and chemogenetics in mice to reveal the role of different types of GABAergic interneurons for visual learning. Clopath will discuss biologically-inspired computational models of inhibitory circuits and their role in long-term plasticity across stages of learning. Morrone and Frangou will present human brain imaging studies employing high-field MR spectroscopy to measure changes in GABA concentration related to learning and homeostatic plasticity. They will discuss interventions (physical exercise, brain stimulation) that boost homeostatic and experience-dependent plasticity in the visual cortex with translational potential for sensory rehabilitation.
  • Session Time
    17:15 - 17:30
    Session Type
    Award Ceremony
  • Session Time
    17:30 - 18:30
    Session Type
    Plenary lecture
  • Session Time
    18:45 - 20:45
    Session Type
    Special interest event
    Session Description
    The Dana Foundation, in collaboration with FENS, SfN, IBRO and other partners of the Global Engagement Initiative, welcome those with an interest in public outreach to a reception celebrating public awareness and engagement. Following introductions, posters from various outreach activities and initiatives, including the international Brain Awareness Week (BAW), will be on display during a networking reception. Scientists and the public alike are encouraged to attend and exchange on different approaches to support public outreach and engagement. The event will host an award ceremony for the Brain Awareness Week Excellence Award winner(s), given to an organizing entity of the best European BAW project of the past two years.
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    The notion of synaptome has recently emerged as the diverse ensemble of synapses established within a circuit of interest. Yet our current knowledge of the molecular synapse diversity within neuronal networks is very poor. Indeed, monitoring the cellular and molecular mechanisms that establish the precise patterns of connectivity and the functional characteristics of synapses has long remained challenging. Recent technological advances provide a very promising entry into the era of synaptomics. Here, we will present our latest contribution and discuss the perspectives in the definition of more precise synaptomes. Dr Anne-Sophie Hafner (Max Planck Institute for Brain Research) will present how local translation at synapses allows for local alterations of the synaptic proteome and neurotransmission in axons and dendrites. Pr Csaba Foldy (University of Zurich) will show how single cell RNA sequencing reveals the mechanisms of adhesion coding through splicing of neurexin proteins. Dr Poulopoulos (University of Maryland) will present how subcellular multi-omic approaches unravel projection specific features. Finally, Dr Fekrije Selimi (Collège de France) will present current knowledge on excitatory synapse differentiation at the different inputs to cerebellar Purkinje cells. Altogether, our symposium will update the community on how molecular approaches of synapse biology contribute to our understanding of network development and function.
  • Session Time
    12:30 - 13:30
    Session Type
    Special interest event
    Session Description
    "Today I wouldn't get an academic job. It's as simple as that. I don't think I would be regarded as productive enough." Peter Higgs, Nobel prize winner The preference for dramatic, novel and positive findings over incremental, reproduced or negative findings within a ‘publish or perish’ culture is jeopardising the reproducibility, replicability, and reliability of neuroscience research. While this issue has been recognised for some time, and is currently being addressed by many research councils, institutes and journals who are adopting credible initiatives, there is still a perceived - or in many cases actual - pressure on neuroscientists to publish ‘high-impact’ articles (and in high numbers). In this special event, we will hear about credibility initiatives that have the potential to increase the reproducibility, replicability, and reliability neuroscience research, which will not only benefit scientific progress in the long-run, but also address a major cause for the poor mental health of research scientists. Following this event, the speakers will be available to answer your questions in an informal setting within the Forum career and training area from 14:30-15:30.
  • Session Time
    13:30 - 14:15
    Session Type
    Special Lecture
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    Understanding the molecular mechanisms that underlie the organization and functions of axons has provided fundamental insights into the function and pathology of neurons. Emerging data implicates myosin II based contractility in the regulation of actin rings, and potentially of other actin-based structures, and thereby multiple aspects of axon biology. Thus, myosin II-actin interactions are providing new insights into the mechanisms by which neurons establish their polarity, how they regulate the initiation of the action potentials, and broadly how they maintain axonal organization and function. Individually obtained findings of the symposium speakers extend and challenge current paradigms. Therefore, we propose to present these new ideas at a FENS Forum 2020 by the leaders of the field. Our goal is to generate new models of how acto-myosin contractility regulates axons. In particular, we will address the following series of questions: What kind of actin structures contract and when? How does contractility affect the functions of neurons? How do actin rings widen to get big cargoes through axons? James Salzer has already published their first article on this topic (Berger et al., Neuron 2018), and the other three speakers have recently submitted their new results for publication. All speakers are experienced presenting their results to a broad multidisciplinary audience and in linking the basic cell biology studies to neuron functionality and animal behavior.
  • Session Time
    18:45 - 20:45
    Session Type
    Special interest event
    Session Description
    The earth’s climate is undoubtedly changing. Although scientists are, to a large extent, receptive of this fact and aware of the causes and consequences of the current environmental crisis, identifying what we can do as a community, at the level of laboratories, research institutions and individually as scientists remains elusive. This special interest event offers a forum to discuss what we can do to adopt a more sustainable model for life-sciences. The organizers will present the results of a small survey performed among neuroscientists and their research institutes to trigger the discussion on the environmental footprint of our community and to start identifying solutions. A panel of academics, activists and life-science industry representatives, among others, will share their viewpoints and experiences implementing concrete actions towards an environmentally friendly life-science framework. In addition to raising awareness on the impact of life sciences on the environment, we will highlight the need to better measure and document this impact, including plastic and Co2 emissions in scientific events and research centers. We also aim to draw up a list of concrete actions that define gold-standards of sustainability for our scientific community. Join us either with your physical presence or by teleconference and add your voice to this discussion! Drinks/snacks will be offered! This special interest event is organized by the FENS-Kavli Scholars (FKNE).
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    Blindness can result either from the loss of photoreceptors in retinal dystrophies or from retinal ganglion cell degeneration in glaucoma or diabetic retinopathy. Gene therapy is just emerging for rare diseases targeting either photoreceptor or retinal ganglion cell degeneration. In the absence of large-scale treatments, the aging of the population is drastically increasing the percentage of affected patients. Recent advances in molecular genetics, cell biology and nanobiotechnologies are elucidating the pathophysiological mechanisms underlying these disorders and aim at identifying new effective therapeutic strategies. Among the most promising approaches, cell reprogramming, optogenetics, neuro-electronic and opto-neural interfaces (retinal prostheses and visual cortex stimulation) are exponentially expanding. The four speakers, who are recognized experts in the specific fields, will report the most recent and fascinating advances in visual restoration in the following topics: cell reprogramming and retina regeneration (M.P. Cosma), optogenetics and infrared-sensitive wireless photovoltaic prosthetics (S. Picaud), polymeric light-sensitive interfaces for retinal prosthetics (F. Benfenati) and electrical stimulation of the visual cortex (X. Chen). The speakers come from 4 distinct European countries and are gender-balanced (2 males and two females) and one speaker is an early career researcher (X. Chen, from the Roelfsema Research Group Vision & Cognition).
  • Session Time
    12:00 - 13:30
    Session Type
    Technical Workshop
    Session Description
    With this workshop, the ALBA Network and The FENS-Kavli Network of Excellence provide an opportunity for supporting the careers of researchers from underrepresented groups working in research. Participants will learn and discuss about the tools and strategies needed for successful career-related negotiations and management of different situations in a scientific career. Senior researchers and FENS-Kavli scholars will attend the session and be sharing experiences from their own careers. Registration is required for this event.
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    The ability to update memories in changing environments is critical for evolutionary fitness. Memories frequently return to a state in which they are destabilised and require synaptic plasticity to be 'reconsolidated' in an updated form. This process could provide a therapeutic opportunity for mental health disorders, such as drug addiction, in which maladaptive memories contribute to the long-term risk of relapse. Thus, understanding the mechanisms of memory destabilisation is important from basic and translational perspectives. This symposium will bring together experts researching memory destabilisation across species, at multiple levels of analysis. Amy Milton (UK), who first demonstrated dissociations in memory retrieval, destabilisation and restabilisation and their dependence on NMDA receptors, will chair. She will also discuss whether 'extinction within the reconsolidation window' engages memory updating mechanisms. Jonathan Ploski (US) will discuss how specific genetic manipulations in NMDA receptor subtype expression and trafficking enhances memory malleability. Johannes Felsenberg (CH) will present circuit-level analyses of memory updating in Drosophila, and discuss the switch between memory updating and new memory formation. Finally, Maria Pedreira (AR) will consider the relationship between memory updating and prediction error, from crabs to humans. This symposium will interest a wide audience, from those working on synaptic plasticity to clinician researchers.
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    Recent advances in optogenetic and viral strategies as well as sophisticated imaging techniques have yielded unprecedented insight into the molecular underpinnings of memory. Converging evidence suggest that memories are stored in part as specific populations of ‘engram’ cells. In this symposium, leading early career memory researchers will share their continuously developing insights on how engram cells contribute to information encoding and storage, across diverse brain regions, species, and behavioral modalities. Emphasis will be given to engram accessibility across development, during sleep deprivation, and following stress. Altogether, this symposium will foster our understanding of how engram connectivity relates to memory fidelity and endurance, which in turn may edify strategies to improve memory precision under environmentally challenging conditions and in central nervous system disorders. Upon attending this symposium, participants should be able to: 1) Understand how sleep deprivation impact cognitive processes at the level of memory engrams in the hippocampus. 2) Describe how the hippocampus segregates fear and reward engrams at the population and projection-specific level. 3) Recapitulate how memory engrams are modulated by postnatal brain development, and how they relate to innate instinctual drives. 4) Integrate knowledge about hippocampal memory mechanisms with network-level accounts of memory processes in the human brain.
  • Session Time
    12:00 - 13:30
    Session Type
    Special interest event
    Session Description
    The emergence of a number of international collaboratives generating vast amounts of brain big data have generated a demand for data sharing that will require an unprecedented level of cooperation to openly share not only our data, but also our tools for making data FAIR, and analyzable. The significant obstacles posed by different data sharing restrictions due to different privacy regulations (like GDPR), differences in the platform usability due to the needs of original stakeholders, or different national ethical restrictions on data acquisition and use, create a confounding landscape for us to navigate. This event is designed to inform the community of the brain data-driven efforts in the international arena, and open the discussion as to how we can combine our resources to achieve greater international cooperation in openly sharing data, AI and best practices - to enable us all to move forward synergistically
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    This symposium will highlight novel research on the role of sex in determining the neurobiological basis, as well as cognitive and emotional aspects of certain neuropsychiatric disorders. Dr. Bangasser will discuss sex differences in stress responses and will focus on the role of CRF in arousal and attention. Dr. Dalla will present sex differences in animal models of depression with a focus on neuroestrogens and neuroplasticity. Dr. Srivastava will show how estradiol induces long-lasting changes in synaptic plasticity via the rapid regulation of local protein translation in the hippocampus. Dr. Milad will present neuroimaging data on the effect of estradiol on neural nodes, as well as computational modelling, in relation to fear and anxiety. Speakers are two women and two men, from four different countries/states, experts on sex differences with complementary, pioneer work on acute brain slices (Srivastava), rodents (Dalla and Bangasser) and humans (Milad) with a wide range of approaches, such as behavioral, molecular, neurochemical, neuroimaging, computational and -omics. The chairperson, Dr. Dalla, is one of the few neuroscientists in Europe promoting sex-oriented research worldwide, has recently led a Special Issue on Sex Differences at Eur. J. of Neuroscience and this symposium will further contribute to this aim. Moreover, it will enhance our understanding of the etiology of disorders, such as depression, anxiety and PTSD, as well as their sex-specific treatment.
  • Session Time
    19:00 - 20:00
    Session Type
    Networking Event
    Session Description
    Come share drinks and meet the ALBA Network, an initiative aiming at enhancing equality and diversity in brain research. Prof. Carmen Sandi, FENS President & Chair of the ALBA Steering Committee, will introduce the network, which will be followed by a casual discussion with other ALBA members about the network's activities.
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    Tanycytes, specialized glial cells lining the third ventricle of hypothalamus mediate the dialogue between the brain and the periphery. These highly plastic and heterogenous cells regulate the secretion of neuropeptides from hypothalamic neurons into the pituitary portal system as well control blood-brain and blood-cerebrospinal fluid exchanges. They also sense and shuttle circulating metabolic signals to hypothalamic neurons involved in regulation of food intake. Tanycytes, thus potentially represent a missing link connecting behavior, hormonal changes, signal transduction and activation of central neurons. Disruptions in these pathways predispose an organism to a number of age-related disorders, including metabolic diseases such as obesity and type 2 diabetes. In order to come up with therapeutic strategies to combat these metabolic and cognitive diseases, it is extremely important to study the heterogeneity of tanycytes as well as to study the molecular basis of their interaction with hypothalamic neurons and the periphery. This symposium brings together 3 basic scientists, who have been awarded an ERC Synergy grant in 2018, and a brilliant young female PI, each working towards deciphering the biology of tanycytes using a unique rationale. The focus of this symposium would be to highlight cutting-edge genetic approaches, systems neuroscience and pharmacological approaches designed to explore the role of tanycytes in health and well-aging.
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    Epigenetics refer to dynamic biological mechanisms that control gene expression and cellular function, without the influence of genomic DNA sequence. Epigenetic mechanisms are vast in nature and include modification of DNA and histones, regulatory RNAs, and chromatin structure. In this-symposium, two well-studied epigenetic mechanisms i.e. the role of chromatin remodelling and DNA methylation will be discussed. These regulatory processes are highly conserved during evolution and play critical roles in central nervous system development. Accordingly, genetic mutation of epigenetic factors or deregulation of these processes leads to human disease and neurodevelopmental disorders. The main objective of this symposium is to provide an up-to-date understanding of molecular epigenetics and mechanism of disease in neurodevelopmental disorders. Four selected speakers are Dr. Nathalie Berube (Western University), Prof. David Picketts (University of Ottawa), Prof. Albert Basson (King’s College London), and Dr. Mojgan Rastegar (University of Manitoba). These speakers are experts in the field with established research programs on epigenetics. They will discuss and present their recent findings on the role of chromatin remodelling and DNA methylation in neurodevelopmental disorders. These discussions are expected to provide important insight towards the translation of basic science research into the therapeutic strategies of human neurodevelopmental disorders.
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    Immune function is closely related to the progression of neurodegenerative diseases. Studies have shown that a reduced adaptive immune response, functional changes in innate immunocytes, and other factors can cause chronic inflammation, which accelerates the pathology of neurological diseases. Recent research has addressed the question of how changes in the body’s immune response affect the central nervous system specifically. Moreover, organ function is empirically known to be influenced by neuronal activity and an individual’s mental state. Many studies have shown that organ function is improved in a comfortable environment and worsened by psychological stress. Information can also travel ‘backwards’ via afferent signaling, from organs to neurons, meaning that changes in organ function can result in changes in neural activity elsewhere in the body. In recent years, there has been renewed interest in and a rapid expansion of research on how various organs interact with the nervous system. The speakers will address, on a cellular and molecular level, the interaction of immune system and nervous system thereby highlighting the function of organ system interactions in neural degeneration processes and during development. Based on mechanistic findings about the linkage between the nervous system and immune system, they will further describe about the possibility of development for treatment of the intractable neurological diseases.
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    Mitochondria (Mt) play a central role in the brain by regulating energy metabolism and cell signalling, contribute to cell plasticity, growth, maturation and communication systems, and are possibly involved in disease pathogenesis and progression. Recent advances have revealed that not only neurons, but also astrocytes require a network of functional Mt in order to produce energy, regulate intracellular homeostasis (including calcium levels), and respond to stress. However, very little is known about how they behave in neurons or astrocytes under particular physiological and pathological conditions, or what influences them biochemically and physically. This applies to various aspects of Mt behavior, including their motility, morphology/distribution and buffering capacity. The aim of this Symposium is to bring together researchers who will highlight recent advances in the functional significance of Mt functions in astrocytes and neurons and will stimulate the scientific community to discuss the role of Mt in brain physiology and pathology. Amit Agarwal and Nicolas Toni will talk about the role of Mt in regulating calcium homeostasis in astrocytes and in the genesis of neurodegenerative diseases, and Franck Polleux and Paola Bezzi will talk about the role of Mt distribution and function in regulating neuronal physiology and in the onset of neuropsychiatric disorders.
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    Neuromodulators, the master switches of the brain, enable a fixed configuration of neurons to shape myriad behavioral patterns. But, how this is achieved is largely unknown. The organizing principles of neuromodulatory logic across cells, synapses, dendrites and microcircuits in health and disease has not been comprehensively covered in recent FENS symposia. Therefore, this propitious symposium will bring together a distinguished panel of junior and senior scientists unifying in vivo, in vitro and in silico approaches developed in global brain initiatives to unravel the functional logic of neuromodulatory circuits in shaping behavioral states. The multidisciplinary panel will deliver insight on how multiple neuromodulatory mechanisms regulate behavioral states in health and disease, foster dialogue, and aim to identify common organizing principles of their engagement across different brain regions and species. Catherine Dulac will present insights on the molecular, cellular and circuit-level modulation of social behaviors. Liqun Luo will highlight the input-output organization of norepinephrine, dopamine, and serotonin systems in the mouse brain. Srikanth Ramaswamy will present a computational framework to predict how cholinergic signaling breaks down during epileptic behavior in cortex. Stephen Williams will highlight the neuromodulatory mechanisms that control active dendritic integration during behaviorally related circuit computations in neocortical pyramidal neurons.
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    Grid cells are defined by the periodic arrangement of their firing fields during exploration of open-field environments. This periodic activity is thought to provide a coordinate system to map our surrounding environment. In recent years, significant advancement has been made towards understanding 1) the network mechanisms generating grid cell firing and 2) the factors affecting grid cell periodicity. This symposium will report on these two key aspects. Laura Colgin will show that during sleep, when sensory inputs are absent, grid cells preserve their firing associations. This work demonstrates that local network interactions rather than sensory inputs determine grid cell co-activity. Gilly Ginosar will present grid cell recordings from bats flying in 3D environments. She will argue that, in 3D, grid cell fields are not organized as a global lattice despite maintaining a short-range organization. Charlotte Boccara will demonstrate that learning new goal locations leads many grid fields to move towards those goals, causing long-lasting distortions of the grid map. Finally, Stefan Leutgeb will stress the importance of local network processing for grid cell accuracy and show that grid cells can encode non-spatial information. Together, these studies present network interactions as critical determinants of grid cell functions and suggest that deviations from periodic firing are integral to grid cell coding.
  • Session Time
    09:45 - 11:15
    Session Type
    Parallel Symposium
    Session Description
    Our thinking on the rules of synaptic plasticity is strongly influenced by Hebb, focusing on the coincidence of electrical activity between pre- and postsynaptic neurons. However new developments have expanded our view: High-resolution imaging and molecular biology techniques have uncovered multiscale biochemical signalling within and between individual synapses. Advances in computational modelling have allowed us to capture this complexity in multi-scale simulations. Results from these studies show that classic Hebbian models are no longer fit for purpose: we need new guiding theories for how synapses perform computations across multiple timescales, and how they communicate at various spatial scales. This symposium brings together experimentalists and computational modellers leading this effort: Kim Blackwell’s team have pioneered efforts to apply computational techniques from systems biology to complex biochemical signalling at synapses. Suhita Nadkarni’s team lead work on biophysical computational modelling of calcium signalling at synapses during plasticity. Thomas Oertner’s team develop genetic tools for all-optical induction and monitoring of plasticity induction at single synapses. Ryohei Yasuda’s team develop genetic probes for FRET/FLIM imaging of temporal activation of proteins at single synapses during plasticity induction. The aim is to offer an update on current work in this field, and spark a dialogue about new multiscale theories of synaptic plasticity.
  • Session Time
    15:45 - 17:15
    Session Type
    Parallel Symposium
    Session Description
    The barrel cortex has emerged as a key model system in neuroscience for studying cortical structure and function. The barrel cortex was discovered in 1970 in a seminal paper by Woolsey and Van der Loos. Next year (2020), it will be the 50-year anniversary of this discovery, and we would like to help celebrate this by organising a barrel cortex symposium at FENS2020 in Glasgow. The anatomical organisation of barrel cortex allows neuroscientists to investigate the structure, function and plasticity of neuronal circuits in the context of a well-defined sensory map. This unique feature of the barrel cortex has allowed spectacular progress to be made over the last decades in the quantitative understanding of the structure and function of cortical circuits, and this will be the subject of this symposium. The four speakers will cover distinct aspects of barrel cortex structure and function: 1. Isabelle Ferezou (Paris, France) will discuss the large-scale functional organization of whisker-representations in dorsal cortex imaged using voltage-sensitive dyes. 2. Christiaan de Kock (Amsterdam, Netherlands) will discuss different functional properties and patterns of activity in morphologically-identified neurons in barrel cortex. 3. Randy Bruno (New York, USA) will discuss layer-specific function of neurons in barrel cortex. 4. Jean-Sebastien Jouhanneau (Berlin, Germany) will discuss synaptic transmission between individual neurons measured in vivo in barrel cortex.