Almudena Alonso-Ojembarrena (Spain)
Puerta del Mar University Hospital Neonatal Intensive Care UnitAuthor Of 1 Presentation
LUNG ULTRASOUND SCORE FOR EARLY PREDICTION OF BPD: PRELIMINARY RESULTS OF DIAGNOSTIC ACCURACY META-ANALYSIS
Abstract
Background and Aims
Lung Ultrasound is a well-established diagnostic tool in neonates as its capability to evaluate pulmonary aeration has been successfully applied for tailored surfactant administration and respiratory support in the first hours of life, as well as for later BPD diagnosis. Recently, Lung Ultrasound has been studied to predict BPD. Thus, we performed a meta-analysis of these data to evaluate the diagnostic accuracy of Lung Ultrasound Score (LUS) for the early prediction of BPD in very and extremely preterm neonates.
Methods
All studies performed on this field were searched on PUBMED database by matching the terms “bpd”, “bronchopulmonary dysplasia”, “predicting”, “Lung Ultrasound Score”. Four studies published between 2018 and 2020 were found and meta-analysis was performed according with PRISMA guidelines.
Results
In the whole population LUS (on 6 chest areas) performed at 1-week post-natal age predicted BPD with an AUC: 0.81, pooled sensitivity: 71% (95%CI:0.62-0.79), I²= 0%, pooled specificity: 80% (95%CI:0.74-0.85), I²= 0%. At 2- weeks post-natal age LUS (on 6 chest areas) showed an AUC: 0.77, pooled sensitivity: 72% (95%CI:0.64-0.80), I²= 0%, pooled specificity 74% (95%CI:0.68-0.79), I²= 91.8%.
Conclusions
While further research is needed, these preliminary findings show that LUS has satisfactory diagnostic accuracy for the early prediction of BPD in very and extremely preterm neonates. Diagnostic accuracy of extended LUS (on more chest areas) needs to be investigated.