University of Tripoli, Faculty of Medicine
Clinical Skill Lab, Pediatric Department
Teaching assistance at clinical skills lab, university of Tripoli, Faculty of Medicine

Author Of 1 Presentation

C-REACTIVE PROTEIN EVALUATION IN DIAGNOSIS OF NEONATAL SEPSIS 

Room
Exhibition Area
Date
19.06.2019
Session Time
10:00 - 16:00
Session Name
POSTER VIEWING 02: Infection, systemic inflammation and sepsis
Presentation Time
07:00 - 18:00
Duration
1 Minute

Abstract

Background

Background: C - reactive protein (CRP) detection is a nonspecific response to neonatal sepsis, but along with clinical symptoms is helpful, it is an early inflammatory marker, and readily available, less costly makes it an easy test to screen for neonatal sepsis especially in developing countries.

Objectives

Objective: The purpose of this study is to evaluate the early detection of CRP and its correlation to blood culture to diagnose neonatal sepsis.

Methods

Methods: The study was conducted in the special care baby unit at the University Hospital of Tripoli (Tripoli Medical Centre) on the period (January 2013 –December2014). Data of 100 neonates under clinical diagnosis of sepsis were reviewed retrospectively. .Blood culture was sent for all neonates, CRP was done quantitatively by rapid latex agglutination method and cut off value of CRP was taken as 6mg/l. Data analysis was carried out by SPSS version 25 and a p-value < 0.05 considered as statistically significant.

Results

00001.jpgOut of 100 patients studied 70% were above 2.500 g, 72% were normal vaginal delivery and 45% presented with fever. CRP was positive in 75 patients and 59 of patients showed Positive blood culture. CRP test showed 80.8% sensitivity and 40.7% specificity, considering blood culture is a gold standard method. A predominate organism is Staphylococcus species followed by Escherichia coli. Mortality rate was 14%, the main isolates in nonsurvival were gram-negative bacteria.

Conclusion

Conclusion: CRP remains a rapid inflammatory marker for screening of neonatal sepsis in the absence of negative blood culture especially in low resources country.

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