Author Of 7 Presentations
INTRODUCTION TO COURSE, PRESENTATION OF PARTICIPANTS AND FACULTY
CARDIAC POCUS AND FUNCTIONAL ECHOCARDIOGRAPHY IN NICU
INTRODUCTION TO COURSE, PRESENTATION OF PARTICIPANTS AND FACULTY
USE OF POINT OF CARE ULTRASOUND (POCUS) AT THE BEDSIDE
LONG TERM OUTCOMES IN INFANTS DIAGNOSED WITH CHRONIC PULMONARY HYPERTENSION: 10-YEAR RETROSPECTIVE STUDY FROM A SINGLE CENTRE
Abstract
Background
Chronic pulmonary hypertension (PH) has been reported to be associated with high morbidity and mortality.
Objectives
1. To understand the pathophysiology of chronic PH in infancy.
2. To study the long-term outcomes in infants diagnosed with PH during infancy.
Methods
A single centre retrospective observational study involving all infants admitted to NICU between 1/1/07 to 1/8/18 and diagnosed with pulmonary hypertension. Data was collected from electronic patient records. Infants with persistent pulmonary hypertension of the newborn were excluded.
Results
A total of 34 infants were diagnosed with PH during this period. The most common association was bronchopulmonary dysplasia (BPD) in 53% cases; details of pathophysiology are summarised in figure 1.
28 infants (82%) received sildenafil, a pulmonary vasodilator, for treatment of PH in this cohort. It was effective (PH resolved or improved) in 57% cases (table 1).
Response | Total no. patients | Non-BPD associated PH | BPD associated PH |
Resolved | 8 (28.5%) | 6 (43%) | 2 (14%) |
Improved | 8 (28.5%) | 3 (21.5%) | 5 (36%) |
Stable | 3 (11%) | 2 (14%) | 1 (7%) |
No response | 9 (32%) | 3 (21.5%) | 6 (43%) |
Overall mortality was 56% (19/34). The long-term outcomes were poorer in PH associated to BPD, with 67% mortality in the BPD group, compared to 44% in the non-BPD group.
Conclusion
Pulmonary hypertension was most commonly associated with BPD when diagnosed during infancy, and in these cases, the risk of mortality is even higher. There is an urgent need of a screening programme for early detection of PH in infants with BPD and study of their outcomes prospectively.