Author Of 2 Presentations
RISK FACTORS AND CLINICAL IMPACT OF PDA IN PRETERM LESS THEN 30 WEEKS OF GESTATION IN A NICU
Abstract
Background
Patent ductus arteriosus (PDA) is a frequent cardiovascular problem in preterm infants.
Objectives
The goal of this study was to evaluate the management and outcomes of hemodynamically significant PDA (HS-PDA) in a level 3 Neonatal Intensive Care Unit (NICU) and to identify possible risk factors and associated morbidities.
Methods
A retrospective study including all newborns (NB) < 30 weeks of gestation admitted with PDA and a comparative study between HS and non-HS PDA was conducted. Data were collected from clinical records between January 2010 and December 2018.
Results
A total of 143 NB was found, 103 HS-PDA and 40 non-HS-PDA.
In 6.8% HS-PDA was managed exclusively with fluid restriction while 93,2% needed medical or surgical (n=9) treatment.
HS-PDA was more frequent in extreme preterm infants (p=0.03) and in NB needing endotracheal intubation in resuscitation at birth (p<0.001).
Respiratory distress syndrome (p=0.006), surfactant administration (p<0.001) and mechanical ventilation > 7 days (p<0.001) were higher in the HS-PDA group
Anemia with transfusion criteria (p=0,014), intra-periventricular hemorrhage (p=0.019) and acute renal injury (p=0.003) were more common in the HS-PDA group.
Hospitalization for >100 days (p=0,039) and mortality (p=0.019) were higher in HS-PDA group.
At the six-month follow up, 2 HS-PDA were referred for surgical ligation.
Conclusion
Immaturity per se, as expected, was associated with HS-PDA with a higher incidence in extreme preterm infants.
In this study, most of the cases were managed with medical treatment.
HS-PDA was associated with worse clinical outcomes leading to higher mortality rates in preterm infants.
IMPACT AND MANAGEMENT OF PDA IN NEWBORNS GREATER THEN 30 WEEKS OF GESTATION IN A NICU
Abstract
Background
Patent ductus arteriosus (PDA) is a common finding in newborns (NB), especially in extreme preterm infants. There are few publications about the impact and approach of this condition in infants > 28 weeks of gestation.
Objectives
Verify the management and impact of PDA in preterm infants > 30 weeks of gestation and term neonates.
Methods
A retrospective study including all NB ≥ 30 weeks of gestation admitted to a level 3 Neonatal Intensive Care Unit with PDA was conducted. Data were collected from clinical records between January 2010 and December 2018. NB with congenital cardiopathy were excluded.
Results
The final sample of 105 NB was divided in two groups:
30 to 33 weeks + 6/7 days (n=64): In 48.4% of the cases echocardiography was performed due to a heart murmur. A hemodynamically significant PDA (HS-PDA) was found in 22 cases and 13 were treated with ibuprofen. At the time of hospital discharge 32 maintained a restrictive PDA compared with only 2 cases at the 6-month follow-up review.
Late preterm and term NB (n=41): Echocardiography was performed mainly due to a heart murmur (41.5%), prenatal suspicion of cardiac anomalies (14.6%) or clinical deterioration (12.2%). HS-PDA was found in 7 cases, one treated with ibuprofen. At the 6-month follow-up review 2 patients maintained a restrictive PDA while 2 needed surgical ligation.
Conclusion
In moderate and late preterm and in term infants HS-PDA mainly presents with a heart murmur. This condition is usually managed with fluid restriction leading to a good clinical outcome.