Background

The purpose of research - to rate the importance of cystatin C in comparison with the calculation of glomerular filtration rate (GFR) based on creatinine levels as a diagnostic marker of renal function disorders in children with acute enteric infections.

Objectives

The study involved 94 children with acute enteric infections. The patients age was from 6 months to 3 years. The study was approved by the local Ethics сommittee. Patients were divided into 3 groups. The first group consisted of 37 (39.4%) children with exsicosis 1 degree. The second group included 32 (34.1%) children with exsicosis 2 degrees. The third group consisted of 25 (26.5%) children with exsicosis 3 degrees.

Methods

For the study of renal function along with clinical tests for all the children measured cystatin C in urine, serum creatinine, produced glomerular filtration rate calculation Schwartz formula for serum creatinine

The content of cystatin C in urine was studied using a set of commercial production firm «Biovendor Human Cystatin C ELISA» (Czech Republic) according to the instructions based on the "sandwich" enzyme immunoassay method.

Results

Thus, the determination of cystatin C concentration revealed early renal dysfunction with varying degrees exsicosis in acute enteric infections in children, which allowed to provide timely treatment of oral rehydration and intravenous injections to replenish lost fluids. The higher the degree of dehydration, the greater the level of cystatin.

Background

The study of risk factors and early neonatal adaptation of full-term newborns born in a condition of hypoxia of varying degrees of severity.

Objectives

There were 49 patients and their children born in terms of 37-41 weeks in a state of hypoxia. 85.1% of puerperas were in the range from 18 to 35 years, 14.9% from 36 to 45 years.

Methods

When assessing the condition of newborns on the Apgar scale in children born at 37-40 weeks, 66.4% in the first minute and 16.9% in the fifth minute were diagnosed with mild hypoxia.

In children born at 40-41 weeks, in the first minute 33.1% were diagnosed with moderate hypoxia, and 44.6% - mild hypoxia. In the fifth minute mild hypoxia was diagnosed in 66.5%. The rest were in satisfactory condition. Among the complications of the early neonatal period of children born from 37 to 40 weeks was noted-cerebral depression syndrome in 20%, intrauterine infection in 17%, transient tachypnea-15%, congenital pneumonia-12%, jaundice – 5%. Early neonatal morbidity in newborns born in the period 40-41 week, presented: cerebral depression syndrome - 25%, congenital pneumonia - 17%, intrauterine infection - 17%, meconic aspiration - 9%, cerebral excitability syndrome - 8%, jaundice - 8% .

Conclusion

The structure of early neonatal morbidity varies depending on the timing of delivery. Cerebral depression syndrome, congenital pneumonia and jaundice were more often diagnosed at 40-41 weeks. The syndrome of meconial aspiration and cerebral excitability were detected, which were not in the terms of 37-40 weeks.

Background

The purpose of research - to rate the importance of cystatin C in comparison with the calculation of glomerular filtration rate (GFR) based on creatinine levels as a diagnostic marker of renal function disorders in children with acute enteric infections.

Objectives

The study involved 94 children with acute enteric infections. The patients age was from 6 months to 3 years. The study was approved by the local Ethics сommittee. Patients were divided into 3 groups. The first group consisted of 37 (39.4%) children with exsicosis 1 degree. The second group included 32 (34.1%) children with exsicosis 2 degrees. The third group consisted of 25 (26.5%) children with exsicosis 3 degrees.

Methods

For the study of renal function along with clinical tests for all the children measured cystatin C in urine, serum creatinine, produced glomerular filtration rate calculation Schwartz formula for serum creatinine

The content of cystatin C in urine was studied using a set of commercial production firm «Biovendor Human Cystatin C ELISA» (Czech Republic) according to the instructions based on the "sandwich" enzyme immunoassay method.

Results

Thus, the determination of cystatin C concentration revealed early renal dysfunction with varying degrees exsicosis in acute enteric infections in children, which allowed to provide timely treatment of oral rehydration and intravenous injections to replenish lost fluids. The higher the degree of dehydration, the greater the level of cystatin.

Background

The study of risk factors and early neonatal adaptation of full-term newborns born in a condition of hypoxia of varying degrees of severity.

Objectives

There were 49 patients and their children born in terms of 37-41 weeks in a state of hypoxia. 85.1% of puerperas were in the range from 18 to 35 years, 14.9% from 36 to 45 years.

Methods

When assessing the condition of newborns on the Apgar scale in children born at 37-40 weeks, 66.4% in the first minute and 16.9% in the fifth minute were diagnosed with mild hypoxia.

In children born at 40-41 weeks, in the first minute 33.1% were diagnosed with moderate hypoxia, and 44.6% - mild hypoxia. In the fifth minute mild hypoxia was diagnosed in 66.5%. The rest were in satisfactory condition. Among the complications of the early neonatal period of children born from 37 to 40 weeks was noted-cerebral depression syndrome in 20%, intrauterine infection in 17%, transient tachypnea-15%, congenital pneumonia-12%, jaundice – 5%. Early neonatal morbidity in newborns born in the period 40-41 week, presented: cerebral depression syndrome - 25%, congenital pneumonia - 17%, intrauterine infection - 17%, meconic aspiration - 9%, cerebral excitability syndrome - 8%, jaundice - 8% .

Conclusion

The structure of early neonatal morbidity varies depending on the timing of delivery. Cerebral depression syndrome, congenital pneumonia and jaundice were more often diagnosed at 40-41 weeks. The syndrome of meconial aspiration and cerebral excitability were detected, which were not in the terms of 37-40 weeks.