David M. Patrick (Canada)

British Columbia Centre for Disease Control Communicable Disease and Immunization Services
Professor David Patrick is an Infectious Disease Physician and Epidemiologist, Director of Research at the British Columbia Centre for Disease Control and Professor of Population and Public Health at the University of British Columbia. His interest is in fostering interdisciplinary approaches to the control of emerging infectious diseases in populations. His current focus is on tracking and controlling antimicrobial resistance and on the relationship between antibiotic use and atopic disease at population level. During the pandemic, he has been chairing BC’s COVID-19 Strategic Research Advisory Committee and working on several fronts to advance the research response in Canada

Author Of 1 Presentation

DURATION OF ANTIBIOTIC PRESCRIPTION AMONG YOUNG CHILDREN IN BRITISH COLUMBIA (BC), CANADA: ROOM FOR IMPROVEMENT

Date
Thu, 12.05.2022
Session Time
10:00 - 11:30
Session Type
Oral Presentations Session
Room
MC 2 HALL
Lecture Time
10:32 - 10:42

Abstract

Backgrounds:

Antibiotic overuse, including unnecessary prescription as well as longer than necessary duration of therapy (DOT), contributes to antibiotic resistance. This study examined the DOT for common infections among children <10 years in BC, Canada.

Methods

In this population-based, retrospective cohort study, prescription and physician billing data generated during 2019 were anonymously linked to determine prescriptions associated with specific diagnoses for children < 10 years of age. These included community acquired pneumonia (CAP), acute otitis media (AOM), cystitis, acute bronchitis, pyelonephritis, and cellulitis. The linked data accounts for >85% community prescriptions with the remainder contributed by other professions who do not use the physician billing system. Median (Q1; first quartile, Q3; third quartile) DOT were examined for the study population, across select diagnoses and stratified by age (<1, 1–4 and 5–9), gender and antibiotic class.

Results:

duration of prescription.pngIn 2019, the overall median (Q1, Q2) DOT, as well as for diagnoses of interest was 7 (7, 10) days. However, the DOT distribution skewed further right for AOM, cellulitis, cystitis and acute bronchitis. Median (Q1, Q3) DOT was 7 (7, 7) days for CAP, 7 (6, 7) days for cystitis, and 7 (7, 10) days for pyelonephritis, acute bronchitis, and suppurative and non-suppurative otitis media. Each DOT distribution was also informed by which antibiotic was used (see figure). For CAP and acute bronchitis, azithromycin was mostly prescribed for 5 days, whereas 26.9% amoxicillin was prescribed for ≥10 days. 84.6%amoxicillin prescribed for otitis media (suppurative and nonsuppurative) among children 5-9 years was ≥ 7 days.

Conclusions/Learning Points:

Antibiotic DOT in children for many indications was longer than current guidelines. Opportunities are present to further reduce unnecessary antibiotic exposure by emphasizing shorter DOT where evidence supports equivalent outcomes.

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Presenter of 1 Presentation

DURATION OF ANTIBIOTIC PRESCRIPTION AMONG YOUNG CHILDREN IN BRITISH COLUMBIA (BC), CANADA: ROOM FOR IMPROVEMENT

Date
Thu, 12.05.2022
Session Time
10:00 - 11:30
Session Type
Oral Presentations Session
Room
MC 2 HALL
Lecture Time
10:32 - 10:42

Abstract

Backgrounds:

Antibiotic overuse, including unnecessary prescription as well as longer than necessary duration of therapy (DOT), contributes to antibiotic resistance. This study examined the DOT for common infections among children <10 years in BC, Canada.

Methods

In this population-based, retrospective cohort study, prescription and physician billing data generated during 2019 were anonymously linked to determine prescriptions associated with specific diagnoses for children < 10 years of age. These included community acquired pneumonia (CAP), acute otitis media (AOM), cystitis, acute bronchitis, pyelonephritis, and cellulitis. The linked data accounts for >85% community prescriptions with the remainder contributed by other professions who do not use the physician billing system. Median (Q1; first quartile, Q3; third quartile) DOT were examined for the study population, across select diagnoses and stratified by age (<1, 1–4 and 5–9), gender and antibiotic class.

Results:

duration of prescription.pngIn 2019, the overall median (Q1, Q2) DOT, as well as for diagnoses of interest was 7 (7, 10) days. However, the DOT distribution skewed further right for AOM, cellulitis, cystitis and acute bronchitis. Median (Q1, Q3) DOT was 7 (7, 7) days for CAP, 7 (6, 7) days for cystitis, and 7 (7, 10) days for pyelonephritis, acute bronchitis, and suppurative and non-suppurative otitis media. Each DOT distribution was also informed by which antibiotic was used (see figure). For CAP and acute bronchitis, azithromycin was mostly prescribed for 5 days, whereas 26.9% amoxicillin was prescribed for ≥10 days. 84.6%amoxicillin prescribed for otitis media (suppurative and nonsuppurative) among children 5-9 years was ≥ 7 days.

Conclusions/Learning Points:

Antibiotic DOT in children for many indications was longer than current guidelines. Opportunities are present to further reduce unnecessary antibiotic exposure by emphasizing shorter DOT where evidence supports equivalent outcomes.

Hide