Welcome to the ESPID 2021 Meeting Calendar

The Meeting will officially run on CEST (GMT + 2 / UTC + 2)

To convert the meeting times to your local time Click Here

The viewing of sessions cannot be accessed from this conference calendar. All sessions are accessible via the Main Lobby at the Virtual Platform.

Icons Legend:  - Live Session  - On Demand Session  - On Demand with Live Q&A - Live ESPID Show

 

Displaying One Session

Session Type
PARALLEL SESSION
Date
Thu, 27.05.2021
Session Time
13:45 - 15:15
Room
Hall 04
Session Icon
Pre-Recorded with Live Q&A

Infectious Diseases Risks in Paediatric Solid Organ Transplant Patients (ID 1825)

PROFESSIONALS´ KNOWLEDGE AND CLINICAL PRACTICES RELATED TO PETS IN TRANSPLANTED CHILDREN. RESULTS FROM AN INTERNATIONAL SURVEY (ID 666)

Lecture Time
14:37 - 14:47
Room
Hall 04

Abstract

Background

Pets have a positive impact on patients´ health, although zoonoses have been reported in transplanted children owning pets.

Methods

A questionnaire was launched among professionals treating transplanted children through international medical societies and research networks.

Results

151 professionals participated (87 centers; 80% European). Most managed solid organ transplants (38%), HSCT 30%, and 25% were infectious diseases specialist. Up to 63% had over 10 years of experience; 48% worked in units attending >100 transplanted children.

Although in 62% there were no specific recommendations regarding pets, in 43% of cases there are initiatives to bring pets to hospitals. A 58% of participants thinks there is not enough evidence regarding pets’ ownership, or he/she is not aware; 30% has previously treated a zoonosis; 68% recognized not to know the rate of patients with pets, 27% would recommend against buying a pet, but 78% would advise to keep it if already at home.

Dogs were considered low-risk pets (70%), while birds, turtles and reptiles were considered high-risk (59, 49 and 45%). 52% of pathogens causing zoonoses were identified as related to animals by ≥70% of infectious diseases professionals, while 13% were identified by ≥70% of other professionals (p=0.004); 72% of infectious disease professionals screened for pets in transplanted patients compared to 32% of other professionals (p<0.001).

For most pathogens, 20-25% of participants were not able to stablish the risk.

Pet owner professionals more frequently advised to have them, while not having owned pets was associated with advising against having one (p=0.058). Having treated zoonoses was associated with changes in clinical practice (p=0.03).

Conclusions

Experienced professionals in pediatric transplant show a lack of knowledge regarding zoonoses, observing significant variability in their clinical practices. Training strategies are urgently needed.

Clinical Trial Registration

Clinical trial registration: PI-4534

Hide

IMPACT OF CENTER-SPECIFIC ANTIMICROBIAL STEWARDSHIP PROGRAM ON CARBAPENEM CONSUMPTION IN PEDIATRIC CRITICALLY ILL PATIENTS (ID 125)

Abstract

Background

Antimicrobial stewardship programs (ASPs) aim to improve antibiotic utilization. Intensive care unit (ICU) setting encountered a high volume of broad-spectrum antibiotic consumption, particularly carbapenems. The computer-assisted post-prescription authorization has been used to authorize carbapenem prescription in Ramathibodi Hospital, Thailand, since 2011, without systematic evaluation. Handshake stewardship is a distinctive approach, focusing on direct communication and a follow-up review of prescribed antibiotics without antibiotic restriction. We aimed to evaluate the impact and acceptability of center-specific ASP, which integrated handshake stewardship to the current computer-assisted post-prescription authorization, in pediatric critically ill patients.

Methods

We performed a pre-and post-implementation study of center-specific ASP, from July 2017 to December 2018, and April 2019 to September 2020, respectively. The primary outcome was the carbapenem consumption rate, measured by days of therapy (DOT) per 1000 patients-ICU days (DOT/1000-ICU days). Secondary outcomes included length of critical care stay (LOCS), 30-day infection-related mortality, carbapenem resistance rate, and acceptability of ASP recommendations.

Results

Two-hundreds and twelve events (163 patients) and 174 events (110 patients) of carbapenem prescription were enrolled in the pre-and post-implementation group, respectively. Carbapenem consumption rate significantly decreased by 45.4% (p < 0.005) (from 667 to 364 DOT/1000-ICU days) (-303 days, 95% Confidence Interval -201.9, -72.6). LOCS, 30-day infection-related mortality, and carbapenem-resistance rate were not significantly different after implementation of ASP. The acceptability of ASP recommendations was 95.4%. Scheduled duration (55.2%) and de-escalation (31.6%) were the two most common ASP recommendations.

Conclusions

Our center-specific ASP, which integrated handshake stewardship and the current computer-assisted post-prescription authorization, significantly reduced carbapenem consumption in pediatric critically ill patients with a high acceptability rate without a negative impact on patients’ clinical outcomes.

Hide