Found 1 Presentation For Request "rythmic"
1629P - Increased incidence of thymic epithelial tumors during COVID-19 pandemic: A retrospective analysis from the French RYTHMIC network
- Jose Carlos Benitez (Villejuif, France)
TETs are rare malignancies ranging from indolent thymoma (T) A to aggressive thymic carcinoma (TC). The incidence rate of TET ranges from 0.13 to 0.32 per 100 000 person/year, although limited data is available. Because of respiratory complications, patients with COVID-19 infection frequently had chest CT-scan, leading to a potential overdiagnosis of asymptomatic thoracic lesion, including TET. Here, we report the incidence rate of TET by year during first decade of the French RYTHMIC network.
RYTHMIC is a French network for TETs composed of national and regional expert centers, with the objective of systematic discussion of patient’s management at a single national tumor board, based on consensual guidelines. We conducted a retrospective analysis of patients from RYTHMIC between January 2012 and April 2022. Data were prospectively collected in the registry. We aimed to assess clinic-pathological and epidemiological characteristics of TETs in RYTHMIC cohort.
3667 pts were included in the analysis. The median age at diagnosis was 63.5 (range 9-91). 15% (n=552) of AIDs, mainly myasthenia Gravis (n=411, 74.4%). T B2 was the most frequent (n=540, 14.7%) followed by AB (10.7%), B3 (6.7%), TC (6.6%), B1 (6.3%) and, A (4%). Most of the pts were diagnosed encapsulated (MK I, n=358) or with invasion of the capsule (MK IIa and IIb, n= 308 and 272, respectively). The prevalence of TETs in France based on RYTHMIC nationwide registry was 0.0054% at 30th of March 2022 cut-off. Incidence is shown in the table. In 2020, incidence x 100 000 person/year was 0.97.
Year New patients (N) France population (M) Increase of population in France Incidence x 100.000 inhabitants Increase incidence in RYTHMIC 173 65,24 - 0,26 - 179 65,56 0,32 0,27 0,01 260 65,9 0,34 0,39 0,12 320 66,42 0,52 0,48 0,09 421 66,6 0,18 0,63 0,15 304 66,77 0,17 0,45 -0,18 358 66,99 0,22 0,53 0,08 388 67,13 0,14 0,57 0,04 654 67,45 0,32 338 67,62 0,17 0,49 -0,48
Incidence of TETs in our network is higher than previously reported. In 2020, we observed a pic in the incidence (170% compared to the average rate), potentially due to the COVID induced CT-scans.
Legal entity responsible for the study
RYTHMIC French network.
Has not received any funding.
All authors have declared no conflicts of interest.