Found 1 Presentation For Request "769P"
769P - Analysis of PMS2 mutation as a potential biomarker for melanoma immunotherapy
- Jiaming `. Qiu (Changshu, China)
Abstract
Background
Several clinical trials have demonstrated that mismatch repair deficiency is significantly associated with long-term immunotherapy-related responses in malignancies treated with immune checkpoint inhibitors (ICIs). The protein encoded by PMS2 gene is a key component of the mismatch repair system. However, whether the PMS2 mutation status is associated with better survival benefit in ICIs treatment melanoma is still unclear.
Methods
Firstly, 418 melanoma samples derived from seven immunotherapy studies (http://www.cbioportal.org/), as discovery cohort, were used to evaluate association between PMS2 mutation and efficacy of immunotherapy. Then the predictive value of PMS2 was validated in 320 melanoma patients from MSKCC cohort (http://www.cbioportal.org/). TMB was calculated as the total count of nonsynonymous mutations in coding sequence.
Results
In discovery cohort, compared to PMS2-wildtype group, longer overall survival (OS) was observed in the PMS2-mutant group (median OS: not reach, NR vs 22.7 months, HR= 0.13, 95% CI: 0.02 to 0.95,
Conclusions
The results indicate that PMS2 somatic mutation is associated with high TMB in melanoma. Analysis of discovery and validation cohort data shows PMS2 mutation is associated with better OS in ICI-treated patients. These findings indicates that PMS2 mutation may serve as a potential predictive biomarker for ICIs in melanoma.
Legal entity responsible for the study
ChangShu No. 2 People's Hospital.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.