Found 2 Presentations For Request "660mo"
660MO - Molecular targets in salivary gland cancers: A comprehensive genomic analysis of 1,666 cases
- Abirami Sivapiragasam (Syracuse, United States of America)
Abstract
Background
Next Generation Sequencing (NGS) to identify key molecular targets is an important aspect of management in advanced Salivary Gland Carcinomas (SGC).
Methods
DNA was extracted from tissues of advanced SGC and Comprehensive Genomic Profiling (CGP) was done to evaluate for base substitutions, short insertions, deletions, copy number changes, gene fusions and rearrangements. Tumor Mutation Burden (TMB) was calculated on up to 1.25 Mb.
Results
The table shows the descriptive analysis of 1,666 SGC with clinically relevant Genomic Alterations (GA). Adenoid Cystic Carcinoma (ACC) (28.3%) was the commonest subtype.
N=1,666 GA (%) TMB > 10 PD-L1 High ACC 471 3.8 2.4 1 3.1 8.6 0.2/0 1.2 4.1 0 0.2 0 AcCC 195 59 37.4 3.6 9.7 2.1 0.5/0 0 0.5 0.5 1.5 3 MEC 118 52.5 30.5 1.7 7.6 16.9 5.9/0 5.1 0 0 16.9 4.2 Myoepi-thelial Carcinoma 55 32.7 23.6 1.8 1.8 9.1 0/0 5.5 7.3 0 7.3 6.3 Ductal Ca 337 24 15.4 5.6 18.1 32.6 16.3/3.6 2.1 1.8 1.2 9.4 3 AdenoCa NOS 152 26.3 19.1 2 7.9 20.4 10.5/2.6 0.7 2 0 5.9 4.4 High Grade Ca NOS 240 22.9 14.6 2.9 10.8 21.3 15.8/2.1 4.2 2.1 0.4 18.3 8.9 Ca ex PA 51 13.7 9.8 2 19.6 11.8 17.6/9.8 11.8 7.8 0 11.8 0 Basaloid Ca 47 10.6 8.5 0 2.1 10.6 0/0 2.1 8.5 0 8.5 0
Conclusions
This large dataset reveals many opportunities for IO and targeted therapy contributing to the continuing increased precision in the selection of treatment for these patients.
Legal entity responsible for the study
The authors.
Funding
Foundation Medicine Inc.
Disclosure
A. Sivapiragasam: Financial Interests, Personal, Advisory Role: Pfizer, Puma Oncology, Blueprint Medicines, Immunomedics. N.A. Danziger: Financial Interests, Personal, Full or part-time Employment: Foundation Medicine Inc.; Financial Interests, Personal, Stocks/Shares: F. Hoffman La-Roche LTd. J.S. Ross: Financial Interests, Personal, Full or part-time Employment, Medical Director: Foundation Medicine; Financial Interests, Personal, Stocks/Shares: Roche Holdings, Tango Therapeutics, Celsius Therapeutics. All other authors have declared no conflicts of interest.
Invited Discussant 660MO, 654MO and 661MO
- Sandra Schmitz (Woluwe-Saint-Lambert, Belgium)