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Found 1 Presentation For Request "486p"
486P - Genetic polymorphism profile associated with cetuximab efficiency in colorectal cancer patients from Kazakhstan
- Irina Kadyrova (Karaganda, Kazakhstan)
Abstract
Background
Colorectal cancer (CRC) is one of the leading causes of mortality from cancer. Cetuximab is a chimeric antibody inhibiting the epidermal growth receptor (EGFR) and has been demonstrated to be effective to treat CRC. However, there are number of single nucleotide polymorphisms (SNPs) leading to a change in the effectiveness of cetuximab treatment. The aim of this study was to investigate SNPs associated with cetuximab efficiency in a Kazakhstan population.
Methods
Genotyping of 9 SNPs associated with cetuximab efficiency (located in 7 different genes on 5 different chromosomes) was performed by QuantStudio 12K Flex PCR and analysed with Thermo Fisher Scientific Cloud service. Statistical analysis was performed with web source [https://www.snpstats.net/]. Log-additive and codominant inheritance models were used for identifying associations.
Results
243 patients with CRC aged from 24 to 87 (female =110; male = 133) and 71 persons from control group, comparable by age and gender, were analysed. Chi-square criteria for SNPs minor allele frequencies (MAF) were calculated. One polymorphism demonstrated significant results (rs2227983 (G/A)) (
Conclusions
One polymorphism (rs2227983) was found to be significantly different between cohorts. In the future, cetuximab efficiency should be further explored in the Kazakhstan population in CRC patients including additional influencing factors.
Legal entity responsible for the study
Karaganda Medical University.
Funding
Ministry of Education and Science of the Republic of Kazakhstan (Research project # BR05236771).
Disclosure
All authors have declared no conflicts of interest.