Antitumor activity by investigator-assessed radiographic response (RECIST 1.1) and toxicity (NCI CTCAE) were determined for pts with advanced, previously treated NSCLC with
As of 27 Jan 2020, 28 pts with previously treated NSCLC and
Mobocertinib demonstrated antitumor activity in pts with advanced NSCLC with
NCT02716116 Release date: March 23, 2016.
Professional medical writing assistance was provided by Lauren Gallagher, RPh, PhD, of Peloton Advantage, LLC, an OPEN Health company, Parsippany, NJ, and funded by Millennium Pharmaceuticals, Inc., Cambridge, MA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
Millennium Pharmaceuticals, Inc., Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
Millennium Pharmaceuticals, Inc., Cambridge, MA, USA, a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
G.J. Riely: Travel/Accommodation/Expenses: Merck, Sharp & Dohme; Research grant/Funding (institution): Novartis; Research grant/Funding (institution): Roche/Genentech; Research grant/Funding (institution): Millennium; Research grant/Funding (institution): GSK; Research grant/Funding (institution): Pfizer; Research grant/Funding (institution): Infinity Pharmaceuticals; Research grant/Funding (institution): ARIAD; Research grant/Funding (institution): Mirati Therapeutics; Research grant/Funding (institution): Merck. J.W. Neal: Advisory/Consultancy: AstraZeneca; Advisory/Consultancy, Research grant/Funding (institution): Genentech/Roche; Advisory/Consultancy, Research grant/Funding (institution): Exelixis; Advisory/Consultancy: Jounce Therapeutics; Advisory/Consultancy, Research grant/Funding (institution): Takeda; Advisory/Consultancy: Lilly; Honoraria (self): Calithera Biosciences; Honoraria (self): Research to Practice; Honoraria (self): MLI Peerview; Honoraria (self): Medscape; Honoraria (self): Biomedical Learning Institute; Honoraria (self): Prime Oncology; Honoraria (self): Rockpointe; Honoraria (self): CME Matters; Honoraria (self): MJH CME; Research grant/Funding (institution): Merck; Research grant/Funding (institution): Novartis; Research grant/Funding (institution): Boehringer Ingelheim; Research grant/Funding (self): Nektar; Research grant/Funding (institution): Adaptimmune; Research grant/Funding (institution): GSK. D.R. Camidge: Honoraria (self): AstraZeneca; Honoraria (self): Takeda; Honoraria (self): Arrys/Kyn; Honoraria (self): Genoptix; Honoraria (self): GI Therapeutics (DSMB); Honoraria (self): Mersana Therapeutics; Honoraria (self): Roche/Genentech; Honoraria (self): Ignyta; Honoraria (self): Daiichi Sankyo (ILD adjudication committee); Honoraria (self): Hansoh SRC; Honoraria (self): Bio-Thera DSMB; Honoraria (self): Lycera; Honoraria (self): Revolution Med; Honoraria (self): Orion; Honoraria (self): Clovis; Honoraria (self): Celgene; Honoraria (self): Novartis; Research grant/Funding (self): ARIAD/Takeda. A. Spira: Advisory/Consultancy: ARIAD; Honoraria (self): AstraZeneca; Honoraria (self): Clovis Oncology; Honoraria (self), Speaker Bureau/Expert testimony: Roche. Z. Piotrowska: Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: AstraZeneca; Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: ARIAD; Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Takeda; Advisory/Consultancy: AbbVie; Advisory/Consultancy, Research grant/Funding (self): Novartis; Advisory/Consultancy, Research grant/Funding (self): Guardant Health; Advisory/Consultancy, Research grant/Funding (self): Spectrum; Advisory/Consultancy: ImmunoGen. L. Horn: Advisory/Consultancy: Merck; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Xcovery; Advisory/Consultancy: Genentech; Advisory/Consultancy: AstraZeneca; Advisory/Consultancy: Incyte; Advisory/Consultancy: EMD Serono; Advisory/Consultancy: Tesaro; Advisory/Consultancy: Pfizer; Advisory/Consultancy: Amgen; Advisory/Consultancy: Bayer; Travel/Accommodation/Expenses: BMS; Research grant/Funding (institution): Boehringer Ingelheim. D.B. Costa: Honoraria (self), Advisory/Consultancy, Research grant/Funding (institution): Takeda/Millennium Pharmaceuticals; Honoraria (self), Research grant/Funding (institution): Pfizer; Advisory/Consultancy, Research grant/Funding (institution): AstraZeneca; Research grant/Funding (institution): Genentech; Research grant/Funding (institution): Merck; Research grant/Funding (institution): Merrimack; Research grant/Funding (institution): Bristol-Myers Squibb; Research grant/Funding (institution): Clovis Oncology; Research grant/Funding (institution): Spectrum. A. Tsao: Advisory/Consultancy: Novartis; Advisory/Consultancy, Research grant/Funding (institution): Boehringer Ingelheim; Advisory/Consultancy, Research grant/Funding (institution): Genentech/Roche; Advisory/Consultancy, Research grant/Funding (institution): MedImmune; Advisory/Consultancy: Imedex; Advisory/Consultancy: Lilly; Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): BMS; Advisory/Consultancy: Epizyme; Advisory/Consultancy: AstraZeneca/MedImmune; Advisory/Consultancy: ARIAD; Advisory/Consultancy: EMD Serono; Advisory/Consultancy: Takeda; Advisory/Consultancy: HERON; Licensing/Royalties: UptoDate; Research grant/Funding (self): Seattle Genetics; Research grant/Funding (self): Millennium; Research grant/Funding (self): Polaris; Research grant/Funding (institution): Merck. J. Patel: Advisory/Consultancy: AbbVie; Advisory/Consultancy: AstraZeneca; Advisory/Consultancy: Takeda. S. Gadgeel: Advisory/Consultancy, Research grant/Funding (institution): Pfizer; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Genentech/Roche; Advisory/Consultancy: ARIAD; Advisory/Consultancy, Speaker Bureau/Expert testimony: AstraZeneca; Advisory/Consultancy: BMS; Advisory/Consultancy: AbbVie; Research grant/Funding (institution), Travel/Accommodation/Expenses: ARIAD/Takeda; Research grant/Funding (self), Research grant/Funding (institution): Merck; Research grant/Funding (institution): Blueprint Medicines. L. Bazhenova: Advisory/Consultancy: Genentech; Advisory/Consultancy, Research grant/Funding (self): BeyondSpring Pharmaceuticals; Advisory/Consultancy: GI Therapeutics; Advisory/Consultancy: AstraZeneca; Advisory/Consultancy: BI; Advisory/Consultancy: Takeda; Advisory/Consultancy: Blueprint; Shareholder/Stockholder/Stock options: Epic Sciences. V.W. Zhu: Honoraria (self), Speaker Bureau/Expert testimony: AstraZeneca; Honoraria (self), Speaker Bureau/Expert testimony: Roche-Foundation Medicine; Honoraria (self), Speaker Bureau/Expert testimony: Roche/Genentech; Honoraria (self), Speaker Bureau/Expert testimony: Takeda; Advisory/Consultancy, Shareholder/Stockholder/Stock options: TP Therapeutics. H. West: Advisory/Consultancy, Speaker Bureau/Expert testimony: Genentech/Roche; Advisory/Consultancy, Speaker Bureau/Expert testimony: Takeda/ARIAD; Advisory/Consultancy, Speaker Bureau/Expert testimony: Novartis; Advisory/Consultancy, Speaker Bureau/Expert testimony: Pfizer. R. Gentzler: Honoraria (self): Rockpointe CME; Advisory/Consultancy: AstraZeneca; Advisory/Consultancy, Research grant/Funding (institution): Pfizer; Research grant/Funding (institution): Merck; Research grant/Funding (institution): Bristol-Myers Squibb; Research grant/Funding (institution): Takeda; Research grant/Funding (institution): Jounce; Research grant/Funding (institution): Helsinn. V. Bunn: Full/Part-time employment: Takeda. S. Jin: Full/Part-time employment: Takeda. Z. Feng: Full/Part-time employment: Takeda. P.A. Jänne: Advisory/Consultancy: Araxes Pharmaceuticals; Advisory/Consultancy: ARIAD/Takeda; Advisory/Consultancy, Research grant/Funding (self): AstraZeneca; Advisory/Consultancy, Research grant/Funding (self): Boehringer Ingelheim; Advisory/Consultancy: Chugai; Advisory/Consultancy: Ignyta; Advisory/Consultancy, Research grant/Funding (self): Lilly; Advisory/Consultancy, Shareholder/Stockholder/Stock options: Loxo Oncology; Advisory/Consultancy: Merrimack; Advisory/Consultancy: Mirati Therapeutics; Advisory/Consultancy: Pfizer; Advisory/Consultancy: Roche; Advisory/Consultancy: Novartis; Advisory/Consultancy: Voronoi; Advisory/Consultancy, Research grant/Funding (self): Daiichi Sankyo; Advisory/Consultancy: SFJ Pharmaceuticals; Advisory/Consultancy: Biocartis; Research grant/Funding (self): Astellas; Research grant/Funding (self): Puma Biotechnology; Shareholder/Stockholder/Stock options: Gatekeeper; Licensing/Royalties, patent on EGFR mutations licensed to LabCorp: Dana-Farber Cancer Institute. All other authors have declared no conflicts of interest.