Channel 2 Proffered Paper session
Date
20.09.2020
Time
16:20 - 18:00
Room
Channel 2
Chairs
  • Antonio Passaro (Milan, Italy)
  • Emanuela Romano (Paris, CEDEX 5, France)
Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

LBA72 - Assessment of clinical and laboratory prognostic factors in patients with cancer and SARS-CoV-2 infection: The COVID-19 and Cancer Consortium (CCC19)

Presentation Number
LBA72
Lecture Time
16:20 - 16:32
Speakers
  • Petros Grivas (Seattle, United States of America)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00

Abstract

Background

The impact of clinicopathologic factors, cancer type, stage or therapies on outcomes of pts with COVID19 is not well defined. We systematically and comprehensively identified and assessed factors associated with high mortality (M) in the largest cohort of pts with cancer and COVID-19.

Methods

CCC19 cohort includes pts with active or prior cancer and COVID-19 across US/international sites and collaborates with ESMO-CoCARE. Analysis was limited to lab-confirmed COVID-19. Primary endpoint: all-cause 30-day M. Multivariable logistic regression was used to assess association between 30-day M and a priori identified demographic/clinicopathologic risk factors (age, sex, race, region, smoking, obesity, comorbidities, ECOG PS, cancer status, recent [in 3 months] cancer treatment, cancer type, baseline COVID19 severity). Exploratory analysis used separate models adjusted for demographic/clinicopathologic factors to assess associations of lab parameters with 30-day M.

Results

As of 31 July 2020, 4169 pts have been accrued; median follow-up 30 days (IQR 21-70), median age 66 (IQR 56-76), 50% men, 92% from US, breast and prostate cancer were most common; 38% had active cancer, 56% required hospitalization and 16% ICU. In 3830 pts with lab confirmed COVID19, 30-day M was 14% overall and 23% in hospitalized pts. Table shows adjusted [a]OR for overall and hospitalized pts. Age, male sex, smoking, >2 comorbidities, ECOG PS≥1, progressive cancer, hematologic or >1 cancer, and severe baseline COVID19 at presentation were associated with worse 30-day M. In hospitalized pts, high or low ALC, high ANC, low platelets, abnormal creatinine, d-dimer, HS-troponin and CRP were also associated with worse 30-day M.

OVERall (N=3819) Hospitalized (N=2168)
Age 1.6 (1.4-1.6) 1.6 (1.4-1.6)
Male 1.3 (1.0-1.6) 1.3 (1.0-1.6)
Ever Smoker 1.3 (1.0-1.6) 0.8 (0.6-1.0)
>2 Comorbidities 2.0 (1.1-3.6) 1.9 (1.0-3.5)
ECOG PS 1 1.8 (1.3-2.6) 0.6 (0.4-0.8)
ECOG PS >1 3.5 (2.5-5.0) 1.8 (1.3-2.4)
progressIVE CA 2.6 (1.8-3.7) 2.4 (1.7-3.5)
Recent Therapy 1.4 (1.0-1.8) 1.4 (1.0-1.8)
HemE CA 1.4 (1.0-1.8) 1.2 (0.9-1.6)
>1 ca 1.4 (1.0-1.9) 1.2 (0.9-1.7)
Mod C19 5.5 (3.9-7.7) 0.7 (0.4-1.0)
Sev C19 23.4 (16.1-34.1) 4.1 (3.1-5.3)
LABs
ALC>ULN 2.1 (1.0-4.2)
ALC<LLN 1.4 (1.1-1.9)
ANC>ULN 1.9 (1.4-2.5)
PLT<LLN 1.4 (1.1-1.8)
AB CREATInine 1.5 (1.2-2.0)
AB D-DIMER 2.0 (1.2-3.5)
AB HS-TROP 2.1 (1.3-3.5)
AB CRP 2.1 (1.1-4.2)

*AB=abnormal.

Conclusions

We confirmed a priori identified risk factors for poor prognosis in the largest COVID-19/cancer cohort and performed initial analysis of lab parameters, informing risk assessment.

Clinical trial identification

NCT04354701.

Legal entity responsible for the study

The COVID-19 and Cancer Consortium (CCC19).

Funding

Has not received any funding.

Disclosure

P. Grivas: Honoraria (self), Research grant/Funding (institution): AstraZeneca; Honoraria (self), Research grant/Funding (institution): Bayer; Honoraria (self), Speaker Bureau/Expert testimony: Bristol-Myers Squibb; Honoraria (self), Research grant/Funding (institution): Clovis Oncology; Honoraria (self): Driver; Honoraria (institution): EMD Serono; Honoraria (self): Exelixis; Honoraria (self): Foundation Medicine; Honoraria (self), Research grant/Funding (institution): Genentech; Honoraria (self): Genzyme; Honoraria (self): GlaxoSmithKline; Honoraria (self): Heron Therapeutics; Honoraria (self): Janssen; Honoraria (self), Research grant/Funding (institution): Merck; Honoraria (self), Research grant/Funding (institution): Mirati Therapeutics; Honoraria (self), Research grant/Funding (institution): Pfizer; Honoraria (self): Roche; Honoraria (self): Seattle Genetics; Honoraria (self), Research grant/Funding (institution): QED Therapeutics; Research grant/Funding (institution): KureIT; Research grant/Funding (institution): Bavarian Nordic; Research grant/Funding (institution): Debiopharm; Research grant/Funding (institution): Immunomedics; Research grant/Funding (institution): Oncogenex. J. Warner: Advisory/Consultancy: IBM Watson Health; Advisory/Consultancy: Westat; Leadership role, Shareholder/Stockholder/Stock options: HemOnc.org LLC; Travel/Accommodation/Expenses: American Society of Clinical Oncology; Research grant/Funding (institution): National Cancer Institute. Y. Shyr: Advisory/Consultancy: Roche; Advisory/Consultancy: Novartis; Advisory/Consultancy: Pfizer; Advisory/Consultancy: Johnson & Johnson; Advisory/Consultancy: GlaxoSmithKline; Advisory/Consultancy, Speaker Bureau/Expert testimony: AstraZeneca; Speaker Bureau/Expert testimony: Boehringer Ingelheim; Speaker Bureau/Expert testimony: Eisai. D. Shah: Research grant/Funding (institution), American Cancer Society and the Hope Foundation for Cancer Research (Mentored Research Scholar Grants in Applied and Clinical Research, MRSG-16-152-01-CCE; PI: Shah DP), and grants from the National Cancer Institute (P30 CA054174; PI: Mesa R): American Cancer Society; Research grant/Funding (institution): National Cancer Institute; Research grant/Funding (institution): Hope Foundation for Cancer Research. N.M. Kuderer: Advisory/Consultancy, Travel/Accommodation/Expenses: BMS; Advisory/Consultancy, Travel/Accommodation/Expenses: Janssen; Advisory/Consultancy: Celldex; Advisory/Consultancy: Invitae; Advisory/Consultancy: Total Health; Advisory/Consultancy: Beyond Springs; Advisory/Consultancy: Bayer; Advisory/Consultancy: Spectrum Pharmaceuticals. T.K. Choueiri: Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): AstraZeneca; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Alexion; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Bayer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Bristol-Myers Squibb/ER Squibb and sons; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Cerulean; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Eisai; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Foundation Medicine; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Exelixis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Ipsen; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Tracon; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Genentech; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): F Hoffmann-La Roche/Roche/Roche Products; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): GlaxoSmithKline; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Eli Lilly; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Merck; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Novartis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Peloton; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Pfizer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Prometheus Labs; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Corvus; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Calithera; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Analysis Group; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Sanofi/Aventis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Takeda; Honoraria (self): EMD Serono; Honoraria (self): Up-to-Date; Honoraria (self): NCCN Analysis Group; Honoraria (self), A healthcare communications company with several brands such as OncLive, PeerView and PER: Michael J Hennessy Associates; Honoraria (self): Research to Practice; Honoraria (self), and Kidney Cancer Journal, Clinical Care Options, Platform Q, Navinata Healthcare, Harborside Press, American Society of Clinical Oncology, New England Journal of Medicine, The Lancet Oncology, Heron Therapeutics: L-path. C. Painter: Shareholder/Stockholder/Stock options: Pfizer; Shareholder/Stockholder/Stock options: Epizyme; Shareholder/Stockholder/Stock options: Inovio; Shareholder/Stockholder/Stock options: OPKO Health Inc.; Shareholder/Stockholder/Stock options: Roche. M.A. Thompson: Honoraria (institution): AbbVie; Honoraria (institution): BMS; Honoraria (institution): CRAB CTC; Honoraria (institution): Denovo; Honoraria (institution): Hoosier Research Network; Honoraria (institution): Lilly; Honoraria (institution): LynxBio; Honoraria (institution): Strata Oncology; Honoraria (institution), Advisory/Consultancy: Takeda; Honoraria (institution): TG Therapeutics; Advisory/Consultancy: Adaptive; Advisory/Consultancy: AIM Specialty Health; Advisory/Consultancy: Celgene (BMS); Advisory/Consultancy: GSK; Advisory/Consultancy: VIA Oncology (now Elsevier Clinical Path); Travel/Accommodation/Expenses, Shareholder/Stockholder/Stock options: Doximity; Travel/Accommodation/Expenses: Syapse; Licensing/Royalties: UpToDate; Non-remunerated activity/ies: Strata Oncology Advisory Board. S. Peters: Honoraria (institution), Advisory/Consultancy: AbbVie; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Amgen; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: AstraZeneca; Honoraria (institution), Advisory/Consultancy: Bayer; Honoraria (institution), Advisory/Consultancy: Biocartis; Honoraria (institution), Advisory/Consultancy: Bioinvent; Honoraria (institution), Advisory/Consultancy: Blueprint Medicines; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Boehringer-Ingelheim; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Bristol-Myers Squibb; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Clovis; Honoraria (institution), Advisory/Consultancy, Travel/Accommodation/Expenses: Daiichi Sankyo; Honoraria (institution), Advisory/Consultancy: Debiopharm; Honoraria (institution), Advisory/Consultancy: Eli Lilly; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): F. Hoffmann-La Roche; Honoraria (institution), Advisory/Consultancy: Foundation Medicine; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Illumina; Honoraria (institution), Advisory/Consultancy: Janssen; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Merck Sharp and Dohme; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Merck Serono; Honoraria (institution), Advisory/Consultancy: Merrimack; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Novartis; Honoraria (institution), Advisory/Consultancy: PharmaMar; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Pfizer; Honoraria (institution), Advisory/Consultancy: Regeneron; Honoraria (institution), Advisory/Consultancy: Sanofi; Honoraria (institution), Advisory/Consultancy, Travel/Accommodation/Expenses: Seattle Genetics; Honoraria (institution), Advisory/Consultancy: Takeda; Honoraria (institution), Advisory/Consultancy: Vaccibody; Travel/Accommodation/Expenses: Roche; Research grant/Funding (institution): Biodesix. A.R. Khaki: Shareholder/Stockholder/Stock options: Pfizer; Shareholder/Stockholder/Stock options: Merck. N.A. Pennell: Advisory/Consultancy: Astrazeneca; Advisory/Consultancy: Merck; Advisory/Consultancy: Eli Lilly; Advisory/Consultancy: Genentech; Advisory/Consultancy: BMS; Advisory/Consultancy: Amgen. B. Halmos: Advisory/Consultancy, Research grant/Funding (institution): AstraZeneca; Advisory/Consultancy, Research grant/Funding (institution): Bristol Myers Squibb; Advisory/Consultancy, Research grant/Funding (institution): Merck; Advisory/Consultancy, Research grant/Funding (institution): Boehringer-Ingelheim; Advisory/Consultancy, Research grant/Funding (institution): Novartis; Advisory/Consultancy: Pfizer; Advisory/Consultancy, Research grant/Funding (institution): Amgen; Advisory/Consultancy: Spectrum; Advisory/Consultancy: Takeda; Advisory/Consultancy, Research grant/Funding (institution): Guardant Health; Advisory/Consultancy: Foundation One; Advisory/Consultancy, Research grant/Funding (institution): Genentech; Research grant/Funding (institution): AbbVie; Research grant/Funding (institution): Advaxis; Research grant/Funding (institution): GSK; Research grant/Funding (institution): Eli-Lilly; Research grant/Funding (institution): Mirati. G.H. Lyman: Advisory/Consultancy: G1 Therapeutics; Advisory/Consultancy: Spectrum; Advisory/Consultancy: Invitae; Advisory/Consultancy: Sandoz; Advisory/Consultancy: Samsung; Advisory/Consultancy: Beyond Spring; Advisory/Consultancy, Travel/Accommodation/Expenses: Bayer; Advisory/Consultancy: Mylan; Research grant/Funding (institution): Amgen. B.I. Rini: Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Merck; Advisory/Consultancy, Research grant/Funding (institution): Roche; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Pfizer; Advisory/Consultancy, Research grant/Funding (institution): AVEO; Advisory/Consultancy: Arravive; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: BMS; Advisory/Consultancy: 3D Medicines; Advisory/Consultancy: Synthorx; Advisory/Consultancy: Surface Oncology; Shareholder/Stockholder/Stock options: PTC Therapeutics; Research grant/Funding (institution): AstraZeneca. G. Lopes: Honoraria (self), Travel/Accommodation/Expenses: Boehringer Ingelheim; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Pfizer; Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): AstraZeneca; Research grant/Funding (institution): Merck Sharp & Dohme; Research grant/Funding (institution): EMD Serono; Research grant/Funding (institution): Blueprint Medicines; Research grant/Funding (institution): Tesaro; Research grant/Funding (institution): Bavarian Nordic; Research grant/Funding (institution): Novartis; Research grant/Funding (institution): G1 Therapeutics; Research grant/Funding (institution): Adaptimmune; Research grant/Funding (institution): BMS; Research grant/Funding (institution): GSK; Research grant/Funding (institution): AbbVie; Research grant/Funding (institution): Rgenix; Research grant/Funding (institution): Roche; Research grant/Funding (institution): Genentech; Research grant/Funding (institution): Lilly; Research grant/Funding (institution), Travel/Accommodation/Expenses: Janssen; Travel/Accommodation/Expenses: E.R. Squibb Sons, LLC. All other authors have declared no conflicts of interest.

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Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

LBA73 - The ORF1ab of SARS-CoV-2 encodes an immunodominant epitope restricted by HLA-A*01:01

Presentation Number
LBA73
Lecture Time
16:32 - 16:44
Speakers
  • Pia Kvistborg (Amsterdam, Netherlands)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00

Abstract

Background

A large global effort is ongoing to develop vaccines against SARS-CoV-2, the causative agent of COVID-19. While there is accumulating information on the antibody response against SARS-CoV-2, less is known about the SARS-CoV-2 antigens that are targeted by CD8 T cells. Such knowledge will be of high value to gain fundamental insights into the antigenic landscape of SARS-CoV-2 recognized by CD8 T cells, to develop tool allowing focused analysis of the SARS-CoV-2 specific T cell responses directly ex vivo, and to understand whether current vaccine designs are covering the CD8 T cell recognized antigens.

Methods

To address this issue, we have analyzed samples from 18 COVID-19 patients for CD8 T cell recognition of 500 predicted SARS-CoV-2-derived epitopes restricted to 10 common HLA-A and HLA-B alleles. For each HLA allele, the top 50 epitopes were selected based on predicted binding affinity and likelihood of successful proteasomal processing. To probe for CD8 T cell recognition of the selected epitope-HLA complexes, we made use of our in-house technology based on multiplexing of peptide HLA (pHLA) multimers conjugated to fluorescent dyes.

Results

In addition to previous studies showing CD8 T cell reactivity towards epitopes derived from the spike protein of SARS-CoV-2, we have identified several CD8 T cell recognized epitopes derived from the ORF1ab, including one epitope displaying clear immunodominant properties across patients positive for HLA-A*01:01. Investigation of the functional status of part of the identified responses (including 4 responses specific for the immunodominant epitope) revealed that the T cell responses were highly dysfunctional. In addition the SARS-CoV-2 specific CD8 T cell responses displayed an increased expression of NKG2A in comparison with bulk CD8 T cells, which may explain their dysfunctional state.

Conclusions

Our data suggest that part of the ORF1ab encodes multiple CD8 T cell antigens including one immunodominant epitope. Noteworthy these epitopes were derived from a part of the viral genome that is not included in the majority of vaccine candidates in development, and this may potentially influence their clinical activity and safety profile.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

Invited Discussant LBA72 and LBA73

Lecture Time
16:44 - 16:54
Speakers
  • Emanuela Romano (Paris, CEDEX 5, France)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00
Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

Q&A and live discussion

Lecture Time
16:54 - 17:04
Speakers
  • Antonio Passaro (Milan, Italy)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00
Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

LBA74 - Disparities in cancer during the COVID-19 pandemic: COVID-19 and cancer outcomes study (CCOS)

Presentation Number
LBA74
Lecture Time
17:04 - 17:16
Speakers
  • Deborah Doroshow (New York, United States of America)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00

Abstract

Background

The COVID-19 pandemic has rapidly altered cancer care. However, the ways in which it has done so and the associated impact at the individual and societal levels remains poorly defined.

Methods

CCOS is a multicenter prospective cohort study designed to define the impact of the pandemic on cancer care delivery and outcomes. The CCOS cohort comprised consecutive outpatients with cancer seen at two US cancer centers from March 2 to March 6, 2020 (index visit). Data was collected at baseline, retrospectively from the preceding 3 months, and prospectively at 3-month follow up. Per patient changes in numbers of visits were compared using Wilcoxon signed rank tests. Correlates of increases in telehealth visits and decreases in in-person visits were evaluated using multivariable logistic regression models. Adjusted Odds ratios [aOR] and 95% confidence intervals (CI) were reported.

Results

Of 2365 included patients, 1219 (51.6%) had a decrease in in-person visit frequency during the pandemic period relative to the preceding 3 months. Conversely, 760 (32.2%) had an increased frequency of telehealth visits (decrease in in-person and increase in telehealth visits; both p<0.01). 128 (5.4%) patients developed COVID-19. Compared to White patients, Black and Hispanic patients were less likely to have telehealth visits, had no significant change in frequency of in-person visits, and were more likely to develop COVID-19 (Table).

N (%); aOR (95% CI)*
Increase in telehealth visits Decrease in in-person visits COVID-19 diagnosis
Non-Hispanic White 508 (37.8%) 1.00 (control) 716 (53.3%) 1.00 (control) 47 (3.5%) 1.00 (control)
Non-Hispanic Black 69 (23.8%) 0.69 (0.50 – 0.94) 151 (50.5%) 0.93 (0.70 – 1.23) 27 (9.0%) 1.86 (1.10 – 3.11)
Hispanic 65 (21.9%) 0.71 (0.51 – 0.98) 154 (51.9%) 1.10 (0.83 – 1.46) 41 (13.8%) 3.19 (2.00 – 5.10)
Other 43 (25.9%) 0.90 (0.60 – 1.32) 82 (49.4%) 0.93 (0.65 – 1.32) 2 (1.2%) 0.25 (0.04 – 0.84)

* Adjusted for cancer disease group, cancer center, cancer status, and receipt of systemic therapy (during index week).

Conclusions

Significant disruptions to routine cancer care were observed during the pandemic period relative to the prior 3 months. Racial and ethnic barriers to the adoption of telehealth, and related socioeconomic factors, place these vulnerable populations simultaneously at disproportionate risk for decreased cancer-related visits and COVID infection, thereby exacerbating existing racial and ethnic health disparities.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

D. Doroshow: Honoraria (self), Advisory/Consultancy, Travel/Accommodation/Expenses: Ipsen; Honoraria (self), Advisory/Consultancy: Boehringer Ingelheim; Honoraria (self), Advisory/Consultancy: Athenaeum Partners; Honoraria (self), Advisory/Consultancy: Boston Healthcare Associates. A.L. Schmidt: Travel/Accommodation/Expenses: Pfizer; Travel/Accommodation/Expenses: Astellas. Z. Bakouny: Non-remunerated activity/ies: Bristol Myers Squibb; Research grant/Funding (self): Genentech/ImCore. M.M. Awad: Advisory/Consultancy, Research grant/Funding (self): Bristol Myers Squibb; Advisory/Consultancy, Research grant/Funding (self): Lilly; Advisory/Consultancy, Research grant/Funding (self): AstraZeneca; Advisory/Consultancy, Research grant/Funding (self): Genentech; Advisory/Consultancy: Merck; Advisory/Consultancy: Achilles; Advisory/Consultancy: AbbVie. R. Haddad: Advisory/Consultancy, Research grant/Funding (self): Bristol Myers Squibb; Advisory/Consultancy, Research grant/Funding (self): Merck; Advisory/Consultancy, Research grant/Funding (self): Pfizer; Advisory/Consultancy, Research grant/Funding (self): Genentech; Advisory/Consultancy, Research grant/Funding (self): AstraZeneca; Advisory/Consultancy, Research grant/Funding (self): GlaxoSmithKline. M.D. Galsky: Shareholder/Stockholder/Stock options: Rappta Therapeutics; Honoraria (self): BioMotiv; Honoraria (self): Janssen; Honoraria (self): Dendreon; Honoraria (self): Merck; Honoraria (self): GlaxoSmithKline; Honoraria (self): Lilly; Honoraria (self): Astellas Pharma; Honoraria (self): Genentech; Honoraria (self): Bristol-Myers Squibb; Honoraria (self): Novartis; Honoraria (self): Pfizer; Honoraria (self): EMD Serono; Honoraria (self): AstraZeneca; Honoraria (self): Seattle Genetics; Honoraria (self): Incyte; Honoraria (self): Alleron Therapeutics; Honoraria (self): Dracen; Honoraria (self): Inovio Pharmaceuticals; Honoraria (self): NuMab; Honoraria (self): Dragonfly Therapeutics; Honoraria (institution): Janssen Oncology; Honoraria (institution): Dendreon; Honoraria (institution): Novartis; Honoraria (institution): Bristol-Myers Squibb; Honoraria (institution): Merck; Honoraria (institution): AstraZeneca; Honoraria (institution): Genentech/Roche. T.K. Choueiri: Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): AstraZeneca; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Alexion; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Bayer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): BristolMyersSquibb; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Cerulean; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Eisai; Honoraria (self), Research grant/Funding (self): Foundation Medicine; Honoraria (self), Research grant/Funding (self): Exelixis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Ipsen; Research grant/Funding (self): 16 Tracon; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Genentech; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Roche; Honoraria (self), Research grant/Funding (self): Roche Products Limited; Honoraria (self), Research grant/Funding (self): Hoffman-LaRoche; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): GlaxoSmithKline; Advisory/Consultancy, Research grant/Funding (self): Lilly; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Merck; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Novartis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Peloton; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Pfizer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Prometheus labs; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Corvus; Research grant/Funding (self): Calithera; Research grant/Funding (self): Analysis Group; Honoraria (self), Research grant/Funding (self): Sanofi/Aventis; Research grant/Funding (self): Takeda; Honoraria (self), Advisory/Consultancy: EMD Serono; Honoraria (self), Advisory/Consultancy: UpToDate; Honoraria (self): NCCN; Honoraria (self), Advisory/Consultancy, Dr. Choueiri reports research support from AstraZeneca, Alexion, Bayer, Bristol Myers Squibb/ER Squibb and sons LLC, Cerulean, Eisai, Foundation Medicine Inc., Exelixis, Ipsen, 16 Tracon, Genentech, Roche, Roche Products Limited, F. Hoffmann-La Roche, GlaxoSmithKline, Lilly, Merck, Novartis, Peloton, Pfizer, Prometheus Labs, Corvus, Calithera, Analysis Group, Sanofi/Aventis, Takeda; Honoraria: AstraZeneca, Alexion, Sanofi/Aventis, Bayer, Bristol Myers-Squibb/ER Squibb and sons LLC, Cerulean, Eisai, Foundation Medicine Inc., Exelixis, Genentech, Roche, Roche Products Limited, F. Hoffmann-La Roche, GlaxoSmithKline, Merck, Novartis, Peloton, Pfizer, EMD Serono, Prometheus Labs, Corvus, Ipsen, Up-to-Date, NCCN, Analysis Group, NCCN, Michael J. Hennessy (MJH) Associates, Inc (Healthcare Communications Company with several brands such as OnClive, PeerView and PER), Research to Practice, L-path, Kidney Cancer Journal, Clinical Care Options, Platform Q, Navinata Healthcare, Harborside Press, American Society of Me: Analysis Group. All other authors have declared no conflicts of interest.

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Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

LBA75 - Defining COVID-19 outcomes in thoracic cancer patients: TERAVOLT (Thoracic cancERs international coVid 19 cOLlaboraTion)

Presentation Number
LBA75
Lecture Time
17:16 - 17:28
Speakers
  • Javier Baena Espinar (Madrid, Spain)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00

Abstract

Background

Patients with thoracic malignancies may have increased risk for COVID-19 mortality. This risk may be attributable to age, comorbidities, smoking history, pulmonary disease burden and cancer-directed therapies.

Methods

TERAVOLT is a global consortium examining outcomes and assessing risk factors associated with mortality of patients with thoracic malignancies and COVID-19 infection.

Results

As of July 15, 2020, 1012 patients from 20 countries have been entered; median age was 68 with 58 % male, 80% current/former smokers, most common comorbidities of HTN (49%) & COPD (26%); 82% NSCLC, 68 % patients with stage IV disease at COVID diagnosis, 65% on treatment (38% chemotherapy, 26% immune checkpoint inhibitor (ICI), 16 % targeted tyrosine kinase inhibitor (TKI). Of these, 72% were hospitalized; 56% of patients developed complications, most frequently pneumonia (40%) and 47% who did not have prior oxygen therapy required it. 32% of patients died during their COVID-19 infection. Only 33 % of patients continued their oncology treatment after infection. Patients presenting with pneumonia (OR 2.7 2-3.5), consolidation (OR 2 CI 1,5-2,8), bilateral lung abnormalities (OR 2,8 CI 2-3,9) and pleural effusion (OR 2,7 CI 1,8-4) were at increased risk of mortality. In multivariate analysis age ≥ 65 (OR 1,53 CI 1,11-2,1), active smoking (OR 2 CI 1,3-3), higher stage of cancer (OR 1,9 CI 1,3-2,7), ECOG PS ≥2 (OR 3,7 CI 2,7-5), steroids prior to COVID diagnosis (OR 1,8 CI 1,2-2,7), were associated with increased risk of death, while chemotherapy and TKI therapy use were not and interestingly patients on immunotherapy appeared to be at decreased risk for mortality (OR 0,6 CI 0,5-0,97).

Conclusions

Facing this ongoing global pandemic, TERAVOLT is the largest thoracic malignancy database confirming the high risk for COVID-19 mortality in this specific patient group. Physicians need to evaluate the risk of mortality from COVID-19 based on age, smoking status, stage of cancer, performance status, need for steroids and specific therapy in order to determine the appropriateness for cancer therapy and tailor patient care taking into account patients’ wishes and status of pandemic in the country.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

J. Baena Espinar: Advisory/Consultancy: AstraZeneca; Honoraria (self), Travel/Accommodation/Expenses: Angelini. F.R. Hirsch: Advisory/Consultancy: AstraZeneca; Advisory/Consultancy: BMS; Advisory/Consultancy: Merck; Advisory/Consultancy: Daiichi; Advisory/Consultancy: Genentech/Roche; Advisory/Consultancy: Lilly/Loxo; Advisory/Consultancy: Boehringer-Ingelheim. M. Tiseo: Honoraria (self), Speaker Bureau/Expert testimony, Research grant/Funding (institution): AstraZeneca; Advisory/Consultancy, Research grant/Funding (institution): Boehringer Ingelheim; Advisory/Consultancy: Novartis; Advisory/Consultancy: MSD; Advisory/Consultancy: BMS; Advisory/Consultancy: Takeda. E. Felip: Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: AbbVie; Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: AstraZeneca; Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Blue Print Medicines; Advisory/Consultancy, Advisory role or speaker's bureau: Boehringer Ingelheim; Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Bristol-Myers Squibb; Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: GSK; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Eli Lilly; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Guardant Health; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Janssen; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Medscape; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Merck KGaA; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Merck Sharp and Dohme; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Novartis; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Pfizer; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: prIME Oncology; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Roche; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Samsung; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Springer; Advisory/Consultancy, Speaker Bureau/Expert testimony, Advisory role or Speaker's bureau: Takeda; Advisory/Consultancy, Advisory role or Speaker's bureau: Touchime; Research grant/Funding (self), Research Funding: Fundacion Merck Salud; Research grant/Funding (institution), Research Funding: Grant for Oncology Innovation; Full/Part-time employment, Board (Independent Member: Grifols Boards. H.A. Wakelee: Research grant/Funding (institution), Clinical Research grant: Gilead; Honoraria (self), Advisory/ Consultancy, advisor or consultant honoraria: AstraZeneca; Advisory/Consultancy, Research grant/Funding (institution), advisor or consultant, research: Xcovery; Advisory/Consultancy, advisor or consultant: Jassen; Advisory/Consultancy, advisor or consultant: Daiichi Sankyo, INC; Advisory/Consultancy, advisor or consultant: Helsinn; Advisory/Consultancy, advisor or consultant: Mirati; Advisory/Consultancy, advisor or consultant (not: Takeda; Advisory/Consultancy, advisor or consultant (not: Cellworks; Advisory/Consultancy, Research grant/Funding (institution), advisor or consultant (not: Genentech/Roche; Advisory/Consultancy, Research grant/Funding (institution), advisor or consultant (not: Merck; Travel/Accommodation/Expenses, CME presentation (travel funding): Clinical care options oncology, LLC; Travel/Accommodation/Expenses, CME presentation (travel funding): Fishawack facilitate LTD; Travel/Accommodation/Expenses, CME presentation (travel funding): Medscape; Travel/Accommodation/Expenses, CME presentation (travel funding): Onclive/intellisphere LLC; Travel/Accommodation/Expenses, CME presentation (travel funding): Philips Gillmore Oncology 2018; Travel/Accommodation/Expenses, CME presentation (travel funding): Physician education resource, LLC/MJH; Travel/Accommodation/Expenses, CME presentation (travel funding): Potomac center for medical education; Travel/Accommodation/Expenses, CME presentation (travel funding): Prime Oncology LLC (2018); Travel/Accommodation/Expenses, CME presentation (travel funding): Primo (2018); Travel/Accommodation/Expenses, CME presentation (travel funding): Research to practice; Travel/Accommodation/Expenses, CME presentation (travel funding): UpToDate; Travel/Accommodation/Expenses, CME presentation (travel funding): WebMdHealth; Honoraria (self), Research grant/Funding (institution), honoraria, research funding to: Novartis; Travel/Accommodation/Expenses, International professional society: RGCON- Rajiv gand conference; Travel/Accommodation/Expenses, International professional society: JLCS - japanese lung cancer society; Travel/Accommodation/Expenses, International professional society: KSMO - korean society of medical oncology; Full/Part-time employment, professor of medicine: Stanford university; Travel/Accommodation/Expenses, Scientific advisory committe - travel: ITMIG; Research grant/Funding (institution), research funding to institution: ACEA biosciences. M.C. Garassino: Honoraria (self): Boehringer Ingelheim; Honoraria (self), Local PI, Enrollment in clinical Trials in: Otsuka Pharma; Honoraria (self), Research grant/Funding (institution), PI, Enrollment and Steering: AstraZeneca; Honoraria (self), Research grant/Funding (institution), PI, Enrollment in clinical Trials in: Novartis; Honoraria (self), Research grant/Funding (institution), PI, Enrollment in clinical Trials in: BMS; Honoraria (self), Research grant/Funding (institution), PI, Enrollment in clinical Trials in: Roche; Honoraria (self), Research grant/Funding (institution), PI, MISP in Thimic malignancies: Pfizer; Honoraria (self), Research grant/Funding (institution), PI, Enrollment in clinical Trials in: Celgene; Research grant/Funding (institution): Incyte; Research grant/Funding (institution): Inivata; Research grant/Funding (self): Takeda; Honoraria (self), PI, Enrollment in clinical Trials Thimic: Tiziana Sciences; Honoraria (self), PI, Enrollment in clinical Trials in: Clovis; Honoraria (self), PI, Enrollment in clinical Trials in: Merck Serono; Honoraria (self), Research grant/Funding (self), PI, Enrollment in clinical Trials in: Bayer; Honoraria (self), Research grant/Funding (institution), PI, Enrollment in clinical Trials in: MSD; Honoraria (self), Local PI, Enrollment and Steering: GlaxoSmithKline S.p.A.; Research grant/Funding (institution): Sanofi-Aventis; Honoraria (self), PI, Enrollment in clinical Trials: Spectrum Pharmaceutcials; Honoraria (self), PI, Enrollment in clinical Trials: Blueprint Medicine; Research grant/Funding (institution): Seattle Genetics; Research grant/Funding (institution): Daiichi Sankyo; Honoraria (self), PI, MISP in Thimic malignancies: Eli Lilly. S. Peters: Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: AbbVie; Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: Amgen; Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: AstraZeneca; Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: Bayer; Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: Biocartis; Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: Boehringer-Ingelheim; Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: Bistrol-Myers Squibb; Honoraria (self), Advisory/Consultancy, Advisory board + honorarium: Clovis; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Daiichi Sankyo; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Debiopharm; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Eli Lilly; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: F. Hoffmann-La Roche; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Foundation Medicine; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Illumina; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Janssen; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Merck Sharp and Dohme; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Merck Serono; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Merrimack; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Novartis; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Pharma Mar; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Pfizer; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Regeneron; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Sanofi; Honoraria (self), Advisory/Consultancy, Advisory Board + honorarium: Seattle Genetics and Takeda; Honoraria (self), Speaker Bureau/Expert testimony, Talk + honorarium: AstraZeneca; Honoraria (self), Speaker Bureau/Expert testimony, Talk + honorarium: Boehringer-Ingelheim; Honoraria (self), Speaker Bureau/Expert testimony, Talk + honorarium: Bristol-Myers Squibb; Honoraria (self), Speaker Bureau/Expert testimony, Talk + honorarium: Eli Lilly; Honoraria (self), Speaker Bureau/Expert testimony, Talk + honorarium: F. Hoffmann-La Roche; Honoraria (self), Speaker Bureau/Expert testimony, Talk + honorarium: Merck Sharp and Dohme. L. Horn: Advisory/Consultancy, Consulting: AstraZeneca; Advisory/Consultancy, Consulting: Genentech-Roche; Advisory/Consultancy, Consulting: Incyte; Advisory/Consultancy, Consulting: Merck; Advisory/Consultancy, Consulting: Pfizer; Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses, Consulting and travel to meeting: Xcovery; Advisory/Consultancy, Consulting: EMD Serono; Advisory/Consultancy, Consulting: Tesaro; Advisory/Consultancy, Consulting: AbbVie; Research grant/Funding (self): Boehringer Ingelheim; Research grant/Funding (self), Travel/Accommodation/Expenses, Honorarium: BMS; Honoraria (self), Honorarium: Medscape; Honoraria (self), Honorarium: PER; Honoraria (self), Honorarium: Research to Practice; Honoraria (self), Honorarium: OncLive; Advisory/Consultancy, Consulting: Amgen; Advisory/Consultancy, Consulting: Bayer. All other authors have declared no conflicts of interest.

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Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

Invited Discussant LBA74 and LBA75

Lecture Time
17:28 - 17:38
Speakers
  • Antonio Passaro (Milan, Italy)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00
Proffered Paper - SARS-CoV-2 and cancer 2 Proffered Paper session

Q&A and live discussion

Lecture Time
17:38 - 17:48
Speakers
  • Antonio Passaro (Milan, Italy)
Room
Channel 2
Date
20.09.2020
Time
16:20 - 18:00