Treated cancer patients (pts) are at high risk to develop severe COVID-19 evolution and guidelines proposed some preventive medical oncologic treatments (tt) adjustments. Pts had to face with this unprecedented situation, as caregivers forced to suddenly adjust their practices. We assessed the pandemic-induced therapeutic modifications of pts cancer tt and the psychological impact on pts and caregivers.
This prospective French study was initiated among pts with solid/hematologic malignancy receiving a medical tt during the lockdown in outpatient departments of 2 cancer centers. Tt modifications were collected from medical records. Perceived and post-traumatic stress (PSS, IES-R), sleep (ISI), quality of life QoL (Fact-G) and cognitive complaint (Fact-Cog) were reported at baseline (during the lockdown) and will be collected at 3 and 6 months. PSS and professional burnout/self-efficacy (MBI, GSES) were also reported by caregivers.
Baseline clinical data are available for 621 pts and questionnaires for 575 pts (93%) and 73 caregivers. Pts and caregivers median ages were 64 [24-89] and 40 [22-63], 69% and 81% women. Caregivers were mainly nurses (48%) and oncologists (30%). 98% of pts had solid tumors, 59% with metastatic disease and 47% de novo treated. Main tts included chemotherapy (72%), immunotherapy (31%) and targeted therapy (13%), 37% starting during the lockdown. 27% of pts had tt modifications including 30% adapted monitoring (mainly phone-consultation), 15% tt interruptions, 32% postponed tt, 19% administration rhythm modifications, more frequently among lung cancer, tt initiated before lockdown, immunotherapy and targeted therapy. Severe perceived stress, post-traumatic stress and insomnia were observed in 6%, 21% and 24% of pts. More pts with tt modifications presented severe post-traumatic stress (27% vs 19%, p=0.05). Tt modifications did not impact on QoL/cognition. Perceived stress score was higher among caregivers than pts (p=0.035) but 2/3 reported professional accomplishment and self efficacy.
Lockdown due to COVID-19 induced tt modification in 1/4 of pts with a majored post-traumatic stress. Despite a high level of stress, caregivers coped with the situation.
NCT04366154, registered on 2020, April, 16th.
Comprehensive Cancer Centre François Baclesse, Caen France.
French Fondation ARC (Cancer Research Association).
All authors have declared no conflicts of interest.
The impact of the COVID-19 (CV-19) pandemic on wellbeing has the potential for serious negative consequences on work, home life and patient care. The ESMO Resilience Task Force collaboration set out to investigate wellbeing in oncology over time since CV-19.
2 online surveys were conducted (survey I April/May; survey II July/August 2020). Statistical analyses were used to examine group differences, associations and to explore predictors of key outcomes: 1) wellbeing/distress (Wellbeing Index (WBI-9)), 2) burnout (1 item); and 3) CV-19 job performance (2 item CJP; standard of care and job delivery compared to pre-CV 19).
Survey I had 1520 participants from 101 countries. Responses indicate that CV-19 is impacting the oncology workforce resulting in a number of changes to work and personal lives. 25% were at risk of distress (poor wellbeing, WBI ≥4); 38% reported feeling burnout and 66% were not able to perform their job compared to pre-CV-19. Higher CJP was significantly associated with better wellbeing and not feeling burnout (p<0.01). Differences were seen in wellbeing and CJP between countries (p<0.001) and related to CV-19 country mortality rate (p<0.05). The main predictors of wellbeing, burnout and CJP were resilience and changes to work hours. Others frequently identified were coping strategies, ethnicity, concern about training/career, worried about current wellbeing, and working conditions. In Survey II, results from 942 participants are undergoing analysis. Overall, comparisons between surveys show overall wellbeing and burnout rates have worsened overtime but CJP has improved. Among 272 participants who completed both surveys, WBI scores ≥4 (indicating higher risk of distress) and burnout rates were higher in survey II compared to survey I (22% vs 31% p=0.01; 35% vs 49% p=0.001 respectively) suggesting wellbeing and burnout may be worsening overtime. CJP improved (38% vs 54% p<0.001).
In the largest global survey series, COVID-19 is impacting on the wellbeing and job performance of oncology professionals. Risk of distress and burnout has increased over time. Urgent measures to address wellbeing and improve resilience are essential.
ESMO.
ESMO.
S. Banerjee: Research grant/Funding (institution): AstraZeneca; Research grant/Funding (self): GSK; Honoraria (self): Amgen; Honoraria (self): AstraZeneca; Honoraria (self): MSD; Honoraria (self): GSK; Honoraria (self): Clovis; Honoraria (self): Genmab; Honoraria (self): Merck Serono; Honoraria (self): Mersana; Honoraria (self): Pfizer; Honoraria (self): Seattle Genetics; Honoraria (self): Tesaro. C. Oing: Research grant/Funding (institution): PharmaMar; Travel/Accommodation/Expenses: Ipsen; Travel/Accommodation/Expenses: PharmaMar; Travel/Accommodation/Expenses: Medac. K. Punie: Honoraria (self): AstraZeneca; Honoraria (self): Eli Lilly; Honoraria (self): Novartis; Honoraria (self): Pfizer; Honoraria (self): Pierre Fabre; Honoraria (self): Hoffmann La Roche; Honoraria (self): Vifor Pharma; Speaker Bureau/Expert testimony: Eli Lilly; Speaker Bureau/Expert testimony: Mundi Pharma; Speaker Bureau/Expert testimony: Novartis; Speaker Bureau/Expert testimony: Pfizer; Speaker Bureau/Expert testimony: Hoffmann La Roche; Honoraria (self): Teva; Research grant/Funding (institution): Sanofi; Travel/Accommodation/Expenses: AstraZeneca; Travel/Accommodation/Expenses: Novartis; Travel/Accommodation/Expenses: Pfizer; Travel/Accommodation/Expenses: PharmaMar; Travel/Accommodation/Expenses: Hoffmann La Roche. M. Lambertini: Advisory/Consultancy: Roche; Advisory/Consultancy: Novartis; Honoraria (institution): Theramex; Honoraria (institution): Takeda; Honoraria (institution): Roche; Honoraria (institution): Lilly; Honoraria (institution): Pfizer; Honoraria (institution): Novartis. C. Benedikt Westphalen: Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Bayer; Honoraria (self), Honoraria (institution), Travel/Accommodation/Expenses: Celgene; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Ipsen; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: MedScape; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Rafael Pharmaceuticals; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: RedHIll; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Roche; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Servier; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Shire; Honoraria (self), Honoraria (institution), Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Taiho; Research grant/Funding (institution): Roche. P. Garrido Lopez: Advisory/Consultancy: AbbVie; Speaker Bureau/Expert testimony: AstraZeneca; Advisory/Consultancy: BluePrint Medicine; Advisory/Consultancy, Speaker Bureau/Expert testimony: Boerhinger Ingelheim; Advisory/Consultancy, Speaker Bureau/Expert testimony: BMS; Advisory/Consultancy: Gilead; Advisory/Consultancy: Guardant Health; Advisory/Consultancy: Janssen; Advisory/Consultancy: Lilly; Advisory/Consultancy, Speaker Bureau/Expert testimony: MSD; Advisory/Consultancy, Speaker Bureau/Expert testimony: Novartis; Advisory/Consultancy, Speaker Bureau/Expert testimony: Pfizer; Advisory/Consultancy, Speaker Bureau/Expert testimony: Roche; Advisory/Consultancy, Speaker Bureau/Expert testimony: Takeda; Speaker Bureau/Expert testimony: Rovi; Speaker Bureau/Expert testimony: Sysmex. T.M.S. Amaral: Honoraria (self), Travel/Accommodation/Expenses: BMS; Honoraria (self), Travel/Accommodation/Expenses: Novartis; Honoraria (self): PIerre Fabre; Honoraria (institution): Neracare; Honoraria (institution): Sanofi. J.B.A.G. Haanen: Advisory/Consultancy: AIMM THerapeutics; Advisory/Consultancy: Amgen; Advisory/Consultancy: AZ; Advisory/Consultancy: Bayer; Advisory/Consultancy: BioNtech; Advisory/Consultancy: BMS; Advisory/Consultancy: GSK; Advisory/Consultancy: Gateta; Advisory/Consultancy: Immunocore; Advisory/Consultancy: Ipsen; Advisory/Consultancy: Merck Serono; Advisory/Consultancy: MSD; Advisory/Consultancy: Molecular Partners; Advisory/Consultancy: Roche; Advisory/Consultancy: Sanofi; Advisory/Consultancy: Seattle Genetics; Advisory/Consultancy: Third Rock Venture; Advisory/Consultancy: Vaximm; Research grant/Funding (institution): Neogene; Research grant/Funding (institution): Amgen; Research grant/Funding (institution): BMS; Research grant/Funding (institution): BIoNthech; Research grant/Funding (institution): MSD; Research grant/Funding (institution): Novartis; Advisory/Consultancy: Genentech. All other authors have declared no conflicts of interest.
SARS-CoV-2 is associated with diverse clinical presentations ranging from asymptomatic infection to lethal complications. Small studies have suggested inferior outcomes in patients (pts) on active cancer treatment. This finding was not independently validated in our prior report on 928 pts, which included treatments administered within 4 weeks of COVID-19 diagnosis. Here, we examine outcomes related to systemic cancer treatment within one year of lab-confirmed SARS-CoV-2 infection in an expanded cohort.
The COVID-19 and Cancer Consortium (CCC19) registry (NCT04354701) was queried for pts ever receiving systemic treatment. Treatment type, cancer type, stage, and COVID-19 outcomes were examined. Pts were stratified by time from last treatment administration: <2 wk, 2-4 wk, 1-3 mo, or 3-12 mo. Standardized incidence ratios (SIR) of mortality by treatment type and timing were calculated.
As of 31 July 2020, we analyzed 3920 pts; 42% received systemic anti-cancer treatment within 12 mo (Table). 159 distinct medications were administered. The highest rate of COVID-19-associated complications were observed in pts treated within 1-3 months prior to COVID-19; all-cause mortality in this group was 26%. 30-day mortality by most recent treatment type was 20% for chemotherapy, 18% for immunotherapy, 17% for chemoradiotherapy, 29% for chemoimmunotherapy, 20% for targeted therapy, and 11% for endocrine therapy. SIR of mortality was highest for chemoimmunotherapy or chemotherapy <2 wks, and lowest for endocrine treatments. A high SIR was also found for targeted agents within 3-12 mo. Pts untreated in the year prior to COVID-19 diagnosis had a mortality of 14%. *Absolute number of pts <5.
Most recent treatment before COVID-19 <2 wk 2-4 wk 1-3 mo 3-12 mo Chemo 30 46 44 45 Immuno (IO) 7 18 8 10 Chemo-IO 2 6 4 * Targeted 39 32 35 25 Endocrine 32 13 19 14 Solid tumor 63 68 63 59 Hematologic 26 18 24 25 Hospitalized 54 54 61 57 O2 required 41 43 45 41 ICU 14 16 17 13 Mech. ventilation 10 11 13 10 Chemo 1.18 (0.77-1.73) 0.92 (0.59-1.36) 0.92 (0.44-1.69) IO 1.03 (0.51-1.85) 1.02 (0.46-1.93) * * Chemo-IO 2.22 (0.95-4.37) * * * Targeted 0.98 (0.74-1.27) 0.97 (0.54-1.60) 1.41 (0.95-2.03) Endocrine * 0.73 (0.31-1.43) *
30-day mortality was highest amongst cancer pts treated 1-3 months prior to COVID-19 diagnosis and those treated with chemoimmunotherapy. Except for endocrine therapy, mortality for subgroups was numerically higher than in pts untreated within a year prior to COVID-19 diagnosis.
NCT04354701.
The COVID-19 and Cancer Consortium (CCC19).
National Cancer Institute (P30 CA068485).
T.M. Wise-Draper: Research grant/Funding (self), Travel/Accommodation/Expenses: AstraZeneca; Research grant/Funding (self): BMS; Research grant/Funding (self): Tesaro/GSK; Advisory/Consultancy: Shattuck Labs; Leadership role, Travel/Accommodation/Expenses, HNC POA Lead: Caris Life Sciences; Research grant/Funding (self), Travel/Accommodation/Expenses: Merck; Travel/Accommodation/Expenses: Eli Lilly; Travel/Accommodation/Expenses: Bexion. A. Elkrief: Research grant/Funding (self): AstraZeneca. B.I. Rini: Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Merck; Advisory/Consultancy, Research grant/Funding (self): Roche; Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Pfizer; Advisory/Consultancy, Research grant/Funding (self): AVEO; Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: BMS; Advisory/Consultancy: arravive; Advisory/Consultancy: 3D medicines; Advisory/Consultancy: Synthorx; Advisory/Consultancy: Surface Oncology; Shareholder/Stockholder/Stock options: PTC Therapeutics; Research grant/Funding (self): AstraZeneca. D.B. Johnson: Advisory/Consultancy: Array Biopharma; Advisory/Consultancy, Research grant/Funding (self): BMS; Advisory/Consultancy: Janssen; Advisory/Consultancy: Merck; Advisory/Consultancy: Novartis; Research grant/Funding (self): Incyte; Leadership role: ASCO melanoma scientific committee chair; Leadership role: NCCN Melanoma committee. G. Lopes: Honoraria (self), Travel/Accommodation/Expenses: Boehringer Ingelheim; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Pfizer; Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): AstraZeneca; Research grant/Funding (institution): Merck; Research grant/Funding (institution): EMD Serono; Research grant/Funding (institution): Blueprint Medicine; Research grant/Funding (institution): Tesaro; Research grant/Funding (institution): Bavarian Nordic; Research grant/Funding (institution): Novartis; Research grant/Funding (institution): GI Therapeutics; Research grant/Funding (institution): adaptimmune; Research grant/Funding (institution): BMS; Research grant/Funding (institution): GSK; Research grant/Funding (institution): AbbVie; Research grant/Funding (institution): Rgenix; Research grant/Funding (institution): Roche; Research grant/Funding (institution): Genentech; Research grant/Funding (institution): Lilly; Research grant/Funding (institution), Travel/Accommodation/Expenses: Janssen; Travel/Accommodation/Expenses: E.R. Squibb Sons LLC. P. Grivas: Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): AstraZeneca; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Bayer; Honoraria (self), Advisory/Consultancy, Speaker Bureau/Expert testimony, Research grant/Funding (self): BMS; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Clovis Oncology; Honoraria (self), Advisory/Consultancy: Driver; Honoraria (self), Advisory/Consultancy: EMD Serono; Honoraria (self), Advisory/Consultancy: Exelixis; Honoraria (self), Advisory/Consultancy: Foundation Medicine; Honoraria (self), Advisory/Consultancy, Research grant/Funding (institution): Genentech; Honoraria (self), Advisory/Consultancy: Genzyme; Honoraria (self), Advisory/Consultancy: GSK; Honoraria (self), Advisory/Consultancy: Heron Therapeutics; Honoraria (self), Advisory/Consultancy: Janssen; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Merck; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Mirati Therapeutics; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Pfizer; Honoraria (self), Advisory/Consultancy: Roche; Honoraria (self), Advisory/Consultancy: Seattle Genetics; Honoraria (self), Advisory/Consultancy: QED Therapeutics; Honoraria (institution): KureIT; Research grant/Funding (self): Bavarian Nordic; Research grant/Funding (self): Debiopharm; Research grant/Funding (self): Immunomedics; Research grant/Funding (self): Oncogenex. M.A. Thompson: Honoraria (self): AbbVie; Honoraria (self): BMS; Honoraria (self): Crab CTC; Honoraria (self): Denovo; Honoraria (self): Hoosier Research Network; Honoraria (self): Lilly; Honoraria (self): LynxBio; Honoraria (self): Strata Oncology; Honoraria (self), Advisory/Consultancy: Takeda; Honoraria (self): TG Therapeutics; Advisory/Consultancy: Adaptive; Advisory/Consultancy: AIM Specialty Health; Advisory/Consultancy: Cellgene (BMS); Advisory/Consultancy: GSK; Advisory/Consultancy: Via Oncology; Travel/Accommodation/Expenses, Shareholder/Stockholder/Stock options: Doximity; Travel/Accommodation/Expenses: Syapse; Licensing/Royalties: Uptodate. S. Peters: Honoraria (self), Honoraria (institution), Advisory/Consultancy: AbbVie; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self): Amgen; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: AstraZeneca; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Bayer; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Biocartis; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Bioinvent; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Blueprint Medicines; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self): Boehringer-Ingelheim; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Bristol-Myers Squibb; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self): Clovis; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Travel/Accommodation/Expenses: Daiichi Sankyo; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Debiopharm; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Eli Lilly; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: F. Hoffmann-La Roche; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Foundation Medicine; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Ilumina; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Janssen; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self), Travel/Accommodation/Expenses: Merck Sharp and Dohme; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self): Merck Serono; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Merrimack; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self): Novartis; Honoraria (self), Honoraria (institution), Advisory/Consultancy: PharmaMar; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Research grant/Funding (self): Pfizer; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Regeneron; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Sanofi; Honoraria (self), Honoraria (institution), Advisory/Consultancy, Travel/Accommodation/Expenses: Seattle Genetics; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Takeda; Honoraria (self), Honoraria (institution), Advisory/Consultancy: Vaccibody; Research grant/Funding (self): Biodesix. N.M. Kuderer: Advisory/Consultancy, Travel/Accommodation/Expenses: BMS; Advisory/Consultancy, Travel/Accommodation/Expenses: Janssen; Honoraria (self), Advisory/Consultancy: Celldex; Honoraria (self), Advisory/Consultancy: Invitae; Honoraria (self), Advisory/Consultancy: Total Health; Honoraria (self), Advisory/Consultancy: Beyond Springs; Honoraria (self), Advisory/Consultancy: BAyer; Honoraria (self), Advisory/Consultancy: Spectrum Pharmaceuticals. S. Gulati: Advisory/Consultancy: Puma Biotechnology; Travel/Accommodation/Expenses: ASCO; Research grant/Funding (self): AstraZeneca; Research grant/Funding (self): IsoRay. T.K. Choueiri: Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): AstraZeneca; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Alexion; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Bayer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): BMS; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Cerulean; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Eisai; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Foundation Medicine; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Exelixis; Advisory/Consultancy, Research grant/Funding (self): Ipsen; Research grant/Funding (self): Tracon; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Genentech; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Roche; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): GSK; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Lilly; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Merck; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Novartis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Peloton; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Pfizer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Promethius Labs; Advisory/Consultancy, Research grant/Funding (self): Corvus; Research grant/Funding (self): Calithera; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self): Analysis Group; Honoraria (self), Research grant/Funding (self): Sanofi/Aventis; Research grant/Funding (self): Takeda; Honoraria (self): EMD Serono; Honoraria (self): Navinata Healthcare; Honoraria (self), Advisory/Consultancy: NCCN; Honoraria (self): Michael J. Hennessy (MJH) Associates, Inc (Healthcare Communications Company with several brands such as OnClive, PeerView and PER); Honoraria (self): Research to Practice; Advisory/Consultancy: Tempus. J. Warner: Advisory/Consultancy: BM Watson Health; Advisory/Consultancy: westat; Leadership role, Shareholder/Stockholder/Stock options: HemOnc.org LLC; Travel/Accommodation/Expenses: American Society of Clinical Oncology. All other authors have declared no conflicts of interest.
The SARS-CoV-2 pandemic in the UK triggered a national characterisation protocol and information on co-morbidities including malignant neoplasm is recorded. A lack of prospective data regarding cancer patients with COVID-19 hampers the development of an evidence based approach in this population. The Clinical Characterisation Protocol-CANCER-UK is a UK multi-disciplinary project aimed at characterising the presentation and course of COVID-19 in cancer patients with the aim of informing practice.
The international Severe Acute Respiratory and emerging Infections Consortium (ISARIC)-4C COVID-19 Clinical Information Network (CO-CIN) collects data on hospital inpatients with proven/high likelihood of COVID-19. Data was collected in 166 UK sites using a questionnaire adopted by the WHO. Data on patients with malignant neoplasm was extracted from the main dataset. We chose a priori to restrict any analysis of outcome to patients who were admitted more than 14 days before data extraction (13th May 2020).
As of 13th May 2020 1797 of 16160 participants had malignant neoplasm (8.6% of all cases). Age<50 62 (3.5%), 50-60 378 (21%), 70-79 558 (31%), 80+ 1002 (42%). Male 1147 (64%); Female 645 (36%). Commonest comorbidities chromic pulmonary disease (22%), chronic kidney disease (21%), uncomplicated diabetes (19%) and dementia (14%). Outcomes 35% discharged alive, 30% care ongoing & 35% died. Admiited to ICU: 150 cases (25% discharged alive,31% care ongoing & 45% died). Receiving invasive ventiation: 67 cases (18% discharged alive, 25% care ongoing:25% & 57% died). HR mortality for malignancy (adjusted for age, sex, other comorbidity): 1.13 (1.02-1.24, p=0.017). Data on presentation will be presented.
Europe’s largest prospective COVID-19 dataset demonstrates that cancer is independently associated with mortality in patients admitted with COVID-19. Data collection is on-going and updated data will be presented including a comparison of cancer vs. non-cancer cohort with regard to presentation, comorbidity and otucomes.
ISRCTN66726260.
No editorial assistance was received.
and international Severe Acute Respiratory and emerging Infections Consortium (ISARIC) WHO Coronavirus Clinical Characterisation Consortium (ISARIC4C).
UK Research and Innovation, Medical Research Council and Department for Health and Social Care.
All authors have declared no conflicts of interest.