Hotspot
ACSé immunotherapy is a nationwide program launched by the French National Cancer Institute (INCa) and sponsored by the French network of comprehensive cancer centres (Unicancer) investigating the efficacy and tolerance of aPD1 in multiple phase II single arm cohorts in rare tumours. We report here the initial results of the
From Apr 2018 to Jan 2020, 15 pts (mean age, 59 years) were included with colorectal (6), endometrial (4), gastric (2), pancreas (1), biliary (1) and glial (1) tumours. Mean number of previous lines of treatment was 2.7. Median follow up was 74 days (Q1-Q3= 40.5-188.5). At the date of submission, nivolumab safety was in accordance with data reported in other tumour types. ORR at 12 weeks in 10 evaluable patients was 30% (PR: n=3; SD: n=4; PD: n=3). Pathogenicity of
We report the first clinical trial assessing aPD1 in
NCT03012581.
UNICANCER.
BMS.
B.J-C. Rousseau: Advisory/Consultancy, Speaker Bureau/Expert testimony: Bayer; Advisory/Consultancy, Speaker Bureau/Expert testimony: Roche; Travel/Accommodation/Expenses: Servier; Travel/Accommodation/Expenses: Astellas; Speaker Bureau/Expert testimony: Gilead. V. Simmet: Honoraria (self): Lilly; Honoraria (self): Servier; Travel/Accommodation/Expenses: Amgen; Travel/Accommodation/Expenses: Novartis. D. Pouessel: Honoraria (self): Ipsen; Honoraria (self), Honoraria (institution): BMS; Honoraria (self), Honoraria (institution), Travel/Accommodation/Expenses: AstraZenca; Honoraria (self): Sanofi; Honoraria (self), Travel/Accommodation/Expenses: Pfizer; Honoraria (self): Merck; Honoraria (self): Astellas; Honoraria (self), Honoraria (institution), Travel/Accommodation/Expenses: Janssen; Honoraria (institution): MSD; Honoraria (institution): Incyte. A. Bruyas: Speaker Bureau/Expert testimony: BMS. F. Rolland: Advisory/Consultancy: Merck KGaA; Advisory/Consultancy: MSD; Advisory/Consultancy: BMS. E. Saada-Bouzid: Advisory/Consultancy: Merck KGaA; Advisory/Consultancy: MSD; Advisory/Consultancy: BMS. R. Cohen: Honoraria (self): Servier; Honoraria (self): Amgen; Honoraria (self): Sanofi. O. Bouche: Honoraria (self), Travel/Accommodation/Expenses: Roche; Honoraria (self): Merck; Honoraria (self), Speaker Bureau/Expert testimony: Amgen; Speaker Bureau/Expert testimony, Travel/Accommodation/Expenses: Bayer; Speaker Bureau/Expert testimony: Pierre Fabre; Speaker Bureau/Expert testimony: Servier; Travel/Accommodation/Expenses: Lilly. A. Marabelle: Speaker Bureau/Expert testimony, Research grant/Funding (self), Travel/Accommodation/Expenses: Roche/Genentech; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: BMS; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: MSD; Research grant/Funding (institution): Pfizer; Advisory/Consultancy, Research grant/Funding (institution): Lytix pharma; Research grant/Funding (institution): Eisai; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: AstraZeneca/Medimmune; Research grant/Funding (institution): Tesaro; Research grant/Funding (institution): Chugai; Advisory/Consultancy: GSK; Advisory/Consultancy: Innate pharma; Advisory/Consultancy: Novartis; Advisory/Consultancy: Bayer. All other authors have declared no conflicts of interest.