Poster Discussion 1 – Translational research Poster Discussion session

1877PD - Prevalence and prognostic effect of high tumor mutation burden (TMB-H) across multiple less common solid cancers using a real-world dataset (ID 2434)

Presentation Number
1877PD
Lecture Time
09:15 - 09:15
Speakers
  • Daniel Backenroth (New York, NY, United States of America)
Location
Salamanca Auditorium (Hall 3), Fira Gran Via, Barcelona, Spain
Date
29.09.2019
Time
08:45 - 09:45

Abstract

Background

Little is known about the prognostic effect of TMB-H among patients with less common cancers who did not receive an immunotherapy (IO).

Methods

The de-identified Flatiron Health-Foundation Medicine (FMI) Clinico-Genomic Database was used to select patients (pts) with any of 10 solid cancers (Table). 109 Pts with confirmed microsatellite instability-high (MSIH) cancers were excluded, of which 101 pts were endometrial cancer. TMB-H was defined as ≥ 10 mutations per megabase (Mut/Mb) with an additional analysis using a cutoff of 13 Mut/Mb. For overall survival (OS) analysis, Pts with IO were excluded if start of IO earlier than or equal to FMI report date (69 pts), or censored if start of IO later than FMI report date (243 pts). OS was analyzed using Kaplan-Meier method and Cox proportional hazard model, adjusting for age, gender, cancer types, practice type and albumin. A non-inferiority test of TMB-H having longer OS than TMB-low (-L) was carried out with a prespecified hazard ratio (HR) of 0.75.

Results

Of the 2,589 pts (table), average age at diagnosis was 64 years and 65% were female. Median TMB was 2.6 Mut/Mb overall, ranged from 1.7 (Meso, salivary, thyroid) to 8.7 (SCLC) Mut/Mb. Overall 12.8% were TMB-H with the highest in SCLC (40.0%) and lowest in meso (1.2%). The adjusted HR (AHR) of TMB-H vs. -L was 0.94 (95% CI: 0.77-1.13) for OS from FMI report date, which met the prespecified threshold for non-inferiority by rejecting the null hypothesis. The AHR was 0.84 (0.67-1.05) using alternative cutoff of 13 Mut/Mb. Comparable results were observed when including MSI-H pts and calculating OS from 1st observed antineoplastic treatment date.

NTMB-H
OS (month, 95%CI)
HRadjustPadjust
n%TMB-HTMB-L
Total2,58933212.88.4 (7.4; 11.4)10.5 (9.5; 11.5)0.94 (0.77; 1.13)0.491
SCLC30512240.06.4 (5.4; 7.5)7.4 (5.5; 10.5)1.03 (0.74; 1.44)0.863
Neuroendocrine1644829.310.4 (6.4; NA)6.4 (4.5; 10.5)0.83 (0.48; 1.44)0.506
Cervical1141714.9NA (6.4; NA)7.4 (4.4; 11.5)0.32 (0.08; 1.31)0.113
Anal1251713.67.4 (2.5; NA)7.5 (5.5; 15.4)0.84 (0.40; 1.79)0.659
Vulvar30413.38.5 (0.5; NA)6.5 (2.5; NA)1.18 (0.22; 6.29)0.848
Salivary1692213.04.5 (3.5; NA)15.5 (10.5; 21.5)1.20 (0.48; 2.99)0.691
Endometrial5906611.211.4 (8.5; 26.5)13.5 (11.5; 15.4)1.15 (0.75; 1.75)0.522
Biliary706284.011.5 (7.4; NA)8.4 (7.4; 10.4)0.65 (0.35; 1.19)0.162
Thyroid22362.710.2 (1.5; NA)27.5 (21.5; NA)1.64 (0.39; 6.96)0.502
Meso16321.2NA12.5 (8.5; 15.5)-0.997

Conclusions

There is a wide range of TMB among these cancers. Non-inferiority testing and HR estimates comparing OS for TMB-H (≥10 Mut/Mb) vs. -L did not support an effect of TMB on OS in the absence of IO for these cancers. Further research is needed to explore whether the prognostic effect of TMB varies by tumor type or threshold.

Legal entity responsible for the study

Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.

Funding

Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.

Disclosure

D. Backenroth: Shareholder / Stockholder / Stock options, Full / Part-time employment: Flatiron Health Inc. C. Shao: Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co. G. Li: Shareholder / Stockholder / Stock options, Full / Part-time employment: Foundation Medicine. L. Huang: Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co.. S.K. Pruitt: Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co., Inc.. E. Castellanos: Full / Part-time employment: Flatiron Health Inc.. G.M. Frampton: Shareholder / Stockholder / Stock options, Full / Part-time employment: Foundation Medicine. K.R. Carson: Full / Part-time employment: Flatiron Health Inc.. T. Snow: Full / Part-time employment: Flatiron Health Inc.. G. Singal: Full / Part-time employment: Foundation Medicine. D. Fabrizio: Shareholder / Stockholder / Stock options, Full / Part-time employment: Foundation Medicine. B.M. Alexander: Shareholder / Stockholder / Stock options, Full / Part-time employment: Foundation Medicine. F.J. Jin: Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co., Inc.. W. Zhou: Shareholder / Stockholder / Stock options, Full / Part-time employment: Merck & Co., Inc..

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