Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care Poster Display session

278P - Intratumoral heterogeneity on dedicated breast positron emission tomography before chemotherapy predicts the outcome of neoadjuvant chemotherapy in breast cancer

Presentation Number
278P
Lecture Time
12:45 - 12:45
Speakers
  • Norio Masumoto (Hiroshima, JP)
Location
Hall A3 - Poster Area Networking Hub, ICM M√ľnchen, Munich, Germany
Date
22.10.2018
Time
12:45 - 13:45

Abstract

Background

Dedicated breast positron emission tomography (DbPET) can detect intratumoral heterogeneity using 18F-fluorodeoxyglucose (FDG). We have proved that intratumoral heterogeneous distribution of FDG on DbPET was significantly related with high nuclear grade and high Ki-67 proliferation index (Breast Cancer Res Treat 2018; 171:315–23). We aimed to evaluate whether intratumoral heterogeneous distribution of FDG on DbPET can predict the effects of neoadjuvant chemotherapy (NAC) on breast cancer.

Methods

We evaluated 58 consecutive patients with breast cancer who underwent DbPET before NAC concurrently between August 2016 and March 2018. The relationships between the pathological response for NAC and the maximum standard uptake values (SUVmax) of DbPET, including estrogen receptor (ER) and human epidermal growth factor receptor type-2 (HER2) statuses, and the intratumoral heterogeneous distribution of FDG on DbPET, were evaluated.

Results

Breast cancer with intratumoral heterogeneous distribution of FDG on DbPET showed a tendency to be related with pathological complete response (pCR) (Table). The SUVmax of DbPET showed an increasing tendency with intratumoral heterogeneous distribution. ER positive-breast cancer with intratumoral heterogeneous distribution showed a tendency to be related with pCR.

Relation between biological factors and pathological response

pCRNon-pCRp
Grade0.17
1–2310
32025
Ki-670.35
< 20%14
≥ 20%2231
ER0.07
positive1524
negative811
HER20.06
positive1311
negative1024
DbPET, intratumoral distribution0.23
Heterogeneity1924
Homogeneity411

Conclusions

The SUVmax of DbPET associates with intratumoral heterogeneous distribution. In addition, intratumoral heterogeneity on DbPET provides predictive value for achieving pCR on ER positive-breast cancer and might inform therapeutic decisions.

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.

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