Poster display session: Breast cancer - early stage, locally advanced & metastatic, CNS tumours, Developmental therapeutics, Genitourinary tumours - prostate & non-prostate, Palliative care, Psycho-oncology, Public health policy, Sarcoma, Supportive care Poster Display session

307P - An international systematic review (SR) of breast cancer (BC) BRCA mutation (BRCAm) prevalence

Presentation Number
307P
Lecture Time
12:45 - 12:45
Speakers
  • Nigel Armstrong (York, GB)
Location
Hall A3 - Poster Area Networking Hub, ICM M√ľnchen, Munich, Germany
Date
22.10.2018
Time
12:45 - 13:45

Abstract

Background

Carriers of BRCAm have an increased risk of developing BC. Considering the availability of BRCAm-targeted advanced breast cancer (aBC) drugs and evolving treatment guidelines, an SR was conducted to summarise the prevalence of BRCAm carriers in the overall BC population and stratified by clinical and demographic subgroups in different countries.

Methods

This SR adhered to the Cochrane method. Electronic databases (eg, Medline & Embase; n = 7) and grey literature sources were searched (Jan 2012 to Nov 2017). Studies reporting on BC BRCAm prevalence were included. BRCA1/2m prevalence (including germline) in BC (overall and aBC), clinical (TNBC, HR+/HER2- BC), and demographic subgroups (race/ethnicity) were summarised.

Results

17,872 records were retrieved; 70 studies were included. Regions/countries: Europe (n = 16), USA (n = 33), Canada (n = 2), Australia (n = 2), Japan (n = 1), South Korea (n = 11), Russia (n = 2), and Israel (n = 3). Only 29 studies explicitly reported BRCA germline status with prevalence ranging from 1.8% in an overall BC population (Sardinia) to 59.52% in a study of BC with family history (Spain). BRCAm prevalence varied widely in 16 overall BC population studies ranging from 2.7% (France) to 23.6% (Italy). Broader BRCAm prevalence ranges were observed in 5 aBC studies, varying from 2% in an overall BC population (France) to 53.8% in a study of Ashkenazi Jews (Israel). 42 reported BRCA1m and BRCA2m separately with no consistent distribution pattern between the 2. In the 24 TNBC studies, prevalence varied from 9.3% in an overall BC population (Australia) to 73.3% in a study of BC with a family history (Israel). BRCA1m prevalence was higher in TNBC studies that reported BRCA1m separately from BRCA2m (16 of 24 studies). In 3 studies of HR+/HER2- BC, BRCAm prevalence varied from 5% (USA) to 9.9% (South Korea). BRCAm prevalence ranged from 14.2% (USA) to 53.8% (Israel) in those of Ashkenazi Jewish ancestry.

Conclusions

Reported BRCAm prevalence in BC varies widely in clinical and demographic subgroups across countries; there are few studies on aBC and most lack germline BRCAm status specification. Further BC BRCAm epidemiologic studies are warranted to validate the prevalence of BRCAm with germline status.

Legal entity responsible for the study

Pfizer, Inc.

Funding

Pfizer, Inc.

Editorial Acknowledgement

Editorial and medical writing support funded by Pfizer Inc. were provided by Edwin Thrower, PhD, Mary Kacillas and Paula Stuckart of Ashfield Healthcare Communications, Middletown, Connecticut.

Disclosure

N. Armstrong, S. Ryder, C. Forbes, A. Chalker, J. Ross, R. Quek: Employee: KSR Ltd. who was paid by Pfizer Inc. to carry out this work.

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