Charlotte Cunningham-Rundles, United States of America

Icahn School of Medicine at Mount Sinai Division of Clinical Immunology
Curriculum Vitae: Charlotte Cunningham-Rundles MD, Ph.D. Duke University, North Carolina B.S: Zoology and Chemistry. Columbia University College of Physicians and Surgeons M.D. Internal Medicine Internship and Residency: Bellevue NYU Medical Center New York University Ph.D. Immunology PROFESSIONAL EXPERIENCE: 1974-1986 Associate Sloan Kettering Institute, NYC 1974-1986 Director, Biochemical Immunology/Immunodeficiency, Sloan Kettering Institute 1976- 1986 Director, Louise Nevelson Laboratory, Sloan Kettering Institute 1974-1986 Attending, Clinical Immunology, Memorial Sloan Kettering Cancer Center 1986-1993 Associate Professor, Dept. of Medicine Mount Sinai Medical Center, NYC 1986-1993 Associate Professor, Dept. of Pediatrics, Mount Sinai Medical Center NYC 1986-1994 Associate Professor, Immunology Institute, Mount Sinai Medical Center, NYC 1986- Director of Immunodeficiency Clinic Mount Sinai Med. Center, NYC 1994 - Professor of Medicine, Division of Clinical Immunology 1994 - Professor of Pediatrics 1994 - Professor of Immunology 2001- Program Director, Allergy Immunology Fellowship Mount Sinai Medical Center 2008- David S Gottesman Professor of Immunology; Mount Sinai School of Medicine 2013- Chief, Division of Clinical Immunology; Department of Medicine 2014- Medical Director Therapeutic Infusion Center; Mount Sinai Medical Center POSITIONS, MEDICAL and RESEARCH SOCIETIES American Federation for Clinical Research Fellow, American College of Physicians Member, American Association of Immunologists, AAI American Association of Immunologists AAI: appointed: Clinical Immunology Committee Fellow, American Academy Asthma Allergy Immunology AAAAI 1999 AAAAI Board of Trustees: 2006-2011 AAAAI Nominations Committee: 2012 AAAAI: Chair, Grant Review Committee 2011-12 Clinical Immunology Society: Elected Councilor 1999 Clinical Immunology Society: Publications Chair, 2000 Clinical Immunology Society: President 2003-2004 Clinical Immunology Society: Chair and organizer: CIS Summer School in Primary Immune Deficiency 2002 - current Member, Allergy Immunology and Transplantation NIH Grant Review Committee1994-1998 Chair, NIH Allergy Immunology Transplantation Grant Review 1996-1998 Chair, Immunology Review National Aeronautics and Space Administration (NASA) 2004-2006 Member, Food and Drug Administration, Blood Safety and Advisory Board 2003-2005 Ad Hoc Member Food and Drug Administration, Blood Safety and Advisory Board 2005- Ad Hoc Member NIAID Grant Review 2011- 2014 Site Visit Reviewer: National Human Genome Research Institute Genetics and Molecular Biology 2013 Site Visit Reviewer: National Institute of Arthritis, Musculoskeletal and Skin Diseases 2016 Founder, Immune Deficiency Foundation (IDF), USIDNET NIH Consortium for Research in Primary Immune Deficiency: 2003 - Chair and Principal investigator, USIDNET NIH Consortium: 2010- International Union of Immunological Societies Expert Committee (IUIS) for Primary Immunodeficiency 2007- member International Union of Immunological Societies Expert Committee (IUIS) for Primary Immunodeficiency 2012- Treasurer, Executive Committee Member, The European Society for Immune Deficiency (ESID) Mucosal Immune Society The Harvey Society The Henry Kunkle Society Advisor: National Organization for Rare Diseases (NORD) Medical Advisory Board: The Jeffrey Modell Foundation Medical Advisory Board: The Immune Deficiency Foundation HONORS, AWARDS: Best Doctors in America 2000- Castle Connolly Top Doctors 2000- SuperDoctors 2008- Distinguished Alumni Award: Durham Academy Patients' Choice Award 2002 - AAAAI Research Award 2003 Lifetime Achievement Award, Jeffrey Modell Foundation 2001 Clinical Immunology Society: President’s Award, 2007 Immune Deficiency Foundation: Boyle Award, 2007. Mount Sinai School of Medicine: Jacobi Medallion 2010 American Society for Microbiology: Abbott Award in Clinical and Diagnostic Immunology, 2011 Dr. Jeffrey Greene Lecture: Children’s Hospital of Philadelphia, 2010 Elliot Ellis Lecture: Academy Asthma Allergy Immunology, 2011 Dr. Betty Wray Lecture: American College of Asthma Allergy and Immunology: 2012 Drs. Alan and Adele Josephson Lecture: Downstate Medical Center, 2013 AAAAI Distinguished Clinician Award: 2014. Clinical Immunology President’s Award: 2017 2019 Virginia Kneeland Frantz '22 Award For Distinguished Women In Medicine. Columbia College of Physicians and Surgeons SELECTED PUBLICATIONS: (from 301 peer-reviewed articles) from 2010 onward 1. Cunningham-Rundles C. How I Treat Common Variable Immune Deficiency. Blood. 2010 Jul 8;116(1):7-15. PubMed: 20332369. 2. Isnardi I, Ng YS, Menard L, Meyers G, Saadoun D, Srdanovic I, Samuels J, Berman J, Buckner JH, Cunningham-Rundles C, Meffre E. Complement receptor 2/CD21-human naive B cells contain mostly autoreactive unresponsive clones. Blood. 2010 Jun 17;115(24):5026-36.PubMed PMID: 20231422; PubMed Central PMCID: PMC3373152. 3. Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L. Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease. Inflamm Bowel Dis. 2011 Jan;17(1):251-9. PubMed PMID: 20629103; PubMed Central PMCID: PMC3102048. 4. He B, Santamaria R, Xu W, Cols M, Chen K, Puga I, Shan M, Xiong H, Bussel JB, Chiu A, Puel A, Reichenbach J, Marodi L, Döffinger R, Vasconcelos J, Issekutz A, Krause J, Davies G, Li X, Grimbacher B, Plebani A, Meffre E, Picard C, Cunningham-Rundles C, Casanova JL, Cerutti A. The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88. Nat Immunol. 2010 Sep;11(9):836-45. PubMed PMID: 20676093; PubMed Central PMCID: PMC3047500. 5. Yu JE, De Ravin SS, Uzel G, Landers C, Targan S, Malech HL, Holland SM, Cao W Harpaz N, Mayer L, Cunningham-Rundles C. High levels of Crohn' disease-associated anti-microbial antibodies are present and independent o colitis in chronic granulomatous disease. Clin Immunol. 2011 Jan;138(1):14-22. PubMed PMID: 20956091; PubMed Central PMCID: PMC3061829. 6. Chinen J, Martinez-Gallo M, Gu W, Cols M, Cerutti A, Radigan L, Zhang L, Potocki L, Withers M, Lupski Jr, Cunningham-Rundles C. Transmembrane Activator and CAML Interactor (TACI) Haploinsufficiency Results In B-Cell Dysfunction In Patients with Smith-Magenis Syndrome. J Allergy Clin Immunol. 2011 Jun;127(6):1579-86: 21514638. 7. Orange JS, Glessner JT, Resnick E, Sullivan KE, Lucas M, Ferry B, Kim CE, Hou C, Wang F, Chiavacci R, Kugathasan S, Sleasman JW, Baldassano R, Perez EE, Chapel H, Cunningham-Rundles C, Hakonarson H. Genome-wide association identifies diverse causes of common variable immunodeficiency. J Allergy Clin Immunol. 2011 Jun;127(6):1360-7.e6. PubMed PMID: 21497890; PubMed Central PMCID: PMC3646656. 8. Marron Tu, Martinez-Gallo M, Yu Je, Cunningham-Rundles C. Toll-Like Receptor 4-, 7-, And 8-Activated Myeloid Cells From Patients With X-Linked Agammaglobulinemia Produce Enhanced Inflammatory Cytokines. J Allergy Clin Immunol. 2012 Jan;129(1):184-190.E4. PubMed: 22088613. 9. Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and Mortality In Common Variable Immune Deficiency Over 4 Decades. Blood. 2012 16;119(7):1650-7, PubMed Central PMCID: 3286343. 10. Gobert D, Bussel Jb, Cunningham-Rundles C, Galicier L, Dechartres A, Berezne A, Bonnotte B, Derevel T, Auzary C, Jaussaud R, Larroche C, Lequellec A, Ruivard M, Seve P, Smail A, Viallard JF, Godeau B, Hermine O, Michel M. Efficacy and Safety of Rituximab In Common Variable Immunodeficiency-Associated Immune Cytopenias: Br J Haematol. 2011 Nov;155(4):498-508 : 21981575 11. Meyers G, Ng YS, Bannock JM, Lavoie A, Walter JE, Notarangelo LD, Kilic SS, Aksu G, Debré M, Rieux-Laucat F, Conley ME, Cunningham-Rundles C, Durandy A, Meffre E. Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11554-9. PubMed PMID: 21700883; PubMed Central PMCID: PMC3136251. 12. Yu Je, Zhang L, Radigan L, Sanchez-Ramon S, Cunningham-Rundles C. TLR-Mediated B Cell Defects and IFN alpha In Common Variable Immunodeficiency. J Clin Immunol. 2012 Feb;32(1):50-60.; PubMed Central PMCID: 3428015. 13. Marron TU, Martinez-Gallo M, Yu JE, Cunningham-Rundles C. Toll-Like Receptor 4-, 7, and 8-Activated Myeloid Cells From Patients With X-Linked Agammaglobulinemia Produce Enhanced Inflammatory Cytokines. J Allergy Clin Immunol. 2012 Jan;129(1):184-90.E1-4.; PMCID: 3428022. 14. Cunningham-Rundles C. Human B cell defects in perspective. Immunol Res. 2012 15. Dec;54(1-3):227-32. Review. PubMed PMID: 22477523; PubMed Central PMCID: PMC3474891. 16. Resnick ES, Bhatt P, Sidi P, Cunningham-Rundles C. Examining the use of ICD-9 diagnosis codes for primary immune deficiency diseases in New York State. J Clin Immunol. 2013 Jan;33(1):40-8. PubMed PMID: 22941512; PubMed Central PMCID: PMC3690548 17. Martinez-Gallo M, Radigan L, Almejun MB, Martinez-Pomar N, Matamoros N, Cunningham-Rundles C. TACI Mutations and Impaired B-Cell Function In Subjects With CVID and Healthy Heterozygotes. J Allergy Clin Immunol. 2013 Feb;131(2):468-76.; PubMed Central PMCID: 3646641. 18. Almejun Mb, Cols M, Zelazko M, Oleastro M, Cerutti A, Oppezzo P, Cunningham-Rundles C, Danielian S. Naturally Occurring Mutation Affecting the MyD88-Binding Site of TNFRSF13b Impairs Triggering of Class Switch Recombination. Eur J Immunol. 2013 Mar;43(3):805-14. PubMed Central PMCID: 3652653. 19. Resnick Es, Bhatt P, Sidi P, Cunningham-Rundles C. Examining The Use Of ICD-9 Diagnosis Codes For Primary Immune Deficiency Diseases in New York State. J Clin Immunol. 2013 Jan;33(1):40-8. Sep 1. PubMed : 22941512. 20. Sullivan KE, Puck JM, Notarangelo LD, Fuleihan R, Caulder T, Wang C, Boyle M, Cunningham-Rundles C. USIDNET: A Strategy To Build A Community Of Clinical immunologists. J Clin Immunol. 2014 May;34(4):428-35. PubMed PMCID: 4046905. 21. Vogel BH, Bonagura V, Weinberg GA, Ballow M, Isabelle J, Diantonio L, Parker A, Young A, Cunningham-Rundles C, Fong Ct, Celestin J, Lehman H, Rubinstein A, Siegel S, Weiner L, Saavedra-Matiz C, Kay Dm, Caggana M. Newborn Screening For SCID In New York State: Experience from the First Two Years. J Clin Immunol. 2014 Apr;34(3):289-303; PubMed Central PMCID: 4090801. 22. Yel L, Rabbat CJ, Cunningham-Rundles C, Orange JS, Torgerson TR, Verbsky JW, Wang Y, Fu M, Robins TS, Edwards MS, Nymann-Andersen J. A Novel Targeted Screening Tool for Hypogammaglobulinemia: Measurement of Serum Immunoglobulin (IgG, IgM, IgA) Levels from Dried Blood Spots (Ig-DBS Assay). J Clin Immunol. 2015 Aug;35(6):573-82.. PubMed PMID: 26275445; PubMed Central PMCID: PMC4572045. 23. Simchoni N, Cunningham-Rundles C. TLR7- and TLR9-responsive human B cell share phenotypic and genetic characteristics. J Immunol. 2015 Apr 1;194(7):3035-44. PubMed: 25740945; PMCID: PMC4369401 24. Garcia-Carmona Y, Cols M, Ting AT, Radigan L, Yuk FJ, Zhang L, Cerutti A, Cunningham-Rundles C. Differential induction of plasma cells by isoforms of human TACI. Blood. 2015 Mar 12;125(11):1749-58. PubMed Central PMCID: PMC4357582. 25. Roskin KM, Simchoni N, Liu Y, Lee JY, Seo K, Hoh RA, Pham T, Park JH, Furm D, Dekker CL, Davis MM, James JA, Nadeau KC, Cunningham-Rundles C, Boyd SD. IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Sci Transl Med. 2015 Aug 26;7(302):302ra135. PubMed: 26311730. 26. Bonilla FA, Barlan I, Chapel H, Costa-Carvalho BT, Cunningham-Rundles C, de la Morena MT, Espinosa-Rosales FJ, Hammarström L, Nonoyama S, Quinti I, Routes JM, Tang ML, Warnatz K. ICON: Common Variable Immunodeficiency Disorders. J Allergy Clin Immunol Pract. 2015 Nov 7. pii: S2213-2198(15)00441-9. PubMed PMID: 26563668. 27. Cols M, Rahman A, Maglione PJ, Garcia-Carmona Y, Simchoni N, Ko HM, Radigan L. Cerutti A, Blankenship D, Pascual V, Cunningham-Rundles C. Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency. J Allergy Clin Immunol. 2015 Nov 2. pii: S0091-6749(15)01351-2. PubMed PMID: 26542033. 28. Picard C, Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Conley ME, Cunningham-Rundles C, Etzioni A, Holland SM, Klein C, Nonoyama S, Ochs HD Oksenhendler E, Puck JM, Sullivan KE, Tang ML, Franco JL, Gaspar HB. Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015. J Clin Immunol. 2015 Oct 19. PubMed PMID: 26482257; PubMed Central PMCID: PMC4659841. 29. Morbach H, Schickel JN, Cunningham-Rundles C, Conley ME, Reisli I, Franco JL, Meffre E. CD19 controls Toll-like receptor 9 responses in human B cells. JAllergy Clin Immunol. 2015 Oct 15. pii: S0091-6749(15)01265-8.] PubMed PMID: 26478008. 30. Li YR, Zhao SD, Li J, Bradfield JP, Mohebnasab M, Steel L, Kobie J, Abrams DJ,Mentch FD, Glessner JT, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Li D, Maggadottir SM, Thomas KA, Qui H, Chiavacci RM, Kim CE, Wang F, Snyder J, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Strisciuglio C, Staiano A, Miele E, Silverberg MS, Lie BA, Punaro M, Russell RK, Wilson DC, Dubinsky MC, Monos DS, Annese V, Munro JE, Wise C, Chapel H, Cunningham-Rundles C, Orange JS, Behrens EM, Sullivan KE, Kugathasan S, Griffiths AM, Satsangi J, Grant SF, Sleiman PM, Finkel TH, Polychronakos C, Baldassano RN, Luning Prak ET, Ellis JA, Li H, Keating BJ, Hakonarson H. Genetic sharing and heritability of paediatric age of onset autoimmune diseases. Nat Commun. 2015 Oct 9;6:8442. PubMed PMID: 26450413; PubMed Central PMCID: PMC4633631 31. Bousfiha A, Jeddane L, Al-Herz W, Ailal F, Casanova JL, Chatila T, Conley ME, Cunningham-Rundles C, Etzioni A, Franco JL, Gaspar HB, Holland SM, Klein C, Nonoyama S, Ochs HD, Oksenhendler E, Picard C, Puck JM, Sullivan KE, Tang ML. The 2015 IUIS Phenotypic Classification for Primary Immunodeficiencies. J Clin Immunol. 2015 Nov;35(8):727-38. 2015 Oct 7. PubMed PMID: 26445875; PubMed Central PMCID: PMC4659854. 32. Romberg N, Virdee M, Chamberlain N, Oe T, Schickel JN, Perkins T, Cantaert T, Rachid R, Rosengren S, Palazzo R, Geha R, Cunningham-Rundles C, Meffre E. TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development. J Allergy Clin Immunol. 2015 Nov;136(5):1315-25. PubMed PMID: 26100089; PubMed Central PMCID: PMC4641026. 33. Maglione PJ, Simchoni N, Cunningham-Rundles C. Toll-like receptor signaling in primary immune deficiencies. Ann N Y Acad Sci. 2015 Nov;1356(1):1-21. PubMed PMID: 25930993; PubMed Central PMCID: PMC4629506. 34. Maglione PJ, Overbey JR, Cunningham-Rundles C. Progression of Common Variable Immunodeficiency Interstitial Lung Disease Accompanies Distinct Pulmonary and Laboratory Findings. J Allergy Clin Immunol Pract. 2015 Nov-Dec;3(6):941-50. PubMed PMID: 26372540; PubMed Central PMCID: PMC4641811 35. Ramesh M, Simchoni N, Hamm D, Cunningham-Rundles C. High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia. Clin Immunol. 2015 Dec;161(2):190-6. 2015 Sep 7. PubMed PMID: 26360253; PubMed Central PMCID: PMC4658265 36. Ruane D, Chorny A, Lee H, Faith J, Pandey G, Shan M, Simchoni N, Rahman A, Garg A, Weinstein EG, Oropallo M, Gaylord M, Ungaro R, Cunningham-Rundles C, Alexandropoulos K, Mucida D, Merad M, Cerutti A, Mehandru S. Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses. J Exp Med. 2016 Jan 11;213(1):53-73. 28. PubMed PMID: 26712806. 37. Kuehn HS, Boisson B, Cunningham-Rundles C, Reichenbach J, Stray-Pedersen A, Gelfand EW, Maffucci P, Pierce KR, Abbott JK, Voelkerding KV, South ST, Augustine NH, Bush JS, Dolen WK, Wray BB, Itan Y, Cobat A, Sorte HS, Ganesan S, Prader S, Martins TB, Lawrence MG, Orange JS, Calvo KR, Niemela JE, Casanova JL, Fleisher TA, Hill HR, Kumánovics A, Conley ME, Rosenzweig SD. Loss of B Cells in Patients with Heterozygous Mutations in IKAROS. N Engl J Med. 2016 Mar 17;374(11):1032-43.doi: 10.1056/NEJMoa1512234. PubMed PMID: 26981933 38. Uzzan M, Ko HM, Mehandru S, Cunningham-Rundles C. Gastrointestinal Disorders Associated with Common Variable Immune Deficiency (CVID) and Chronic Granulomatous Disease (CGD). Curr Gastroenterol Rep. 2016 Apr;18(4):17. doi: 10.1007/s11894-016-0491-3. PubMed PMID: 26951230. 39. Maffucci P, Filion CA, Boisson B, Itan Y, Shang L, Casanova JL, Cunningham-Rundles C. Genetic Diagnosis Using Whole Exome Sequencing in Common Variable Immunodeficiency. Front Immunol. 2016 Jun 13;7:220.. PubMed PMID: 27379089; PubMed Central PMCID: PMC4903998. 40. Requena D, Maffucci P, Bigio B, Shang L, Abhyankar A, Boisson B, Stenson PD,] Cooper DN, Cunningham-Rundles C, Casanova JL, Abel L, Itan Y. CDG: An Online Server for Detecting Biologically Closest Disease-Causing Genes and its Application to Primary Immunodeficiency. Front Immunol. 2018;9:1340 PubMed PMID: 29997612; PubMed Central PMCID: PMC6030251. 41.Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, LuQing Xu M, Lambert M, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E. CVID patients with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. J Allergy Clin Immunol. 2018. pii: S0091-6749(18)30897-2. PubMed PMID: 29935219. 42. Ho HE, Byun M, Cunningham-Rundles C. Disseminated Cutaneous Warts in X-Linked Hyper IgM Syndrome. J Clin Immunol. 2018 May;38(4):454-456. PubMed PMID: 29730845; PubMed CentralPMCID: PMC6030472. 43. Farmer JR, Ong MS, Barmettler S, Yonker LM, Fuleihan R, Sullivan KE, Cunningham-Rundles C; USIDNET Consortium, Walter JE. Common Variable Immunodeficiency Non-Infectious Disease Endotypes Redefined Using Unbiased Network Clustering in Large Electronic Datasets. Front Immunol. 2018 Jan 9;8:1740... PubMed PMID: 29375540; PubMed Central PMCID: PMC5767273. 44. Picard C, Bobby Gaspar H, Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Crow YJ, Cunningham-Rundles C, Etzioni A, Franco JL, Holland SM, Klein C, Morio T, Ochs HD, Oksenhendler E, Puck J, Tang MLK, Tangye SG, Torgerson TR, Sullivan KE. International Union of Immunological Societies: 2017 Primary Immunodeficiency Diseases Committee Report on Inborn Errors of Immunity. J Clin Immunol. 2018 Jan;38(1):96-128. doi: 10.1007/s10875-017-0464-9. Epub 2017 Dec 11. PubMed PMID: 29226302; PubMed Central PMCID: PMC5742601 45. Bousfiha A, Jeddane L, Picard C, Ailal F, Bobby Gaspar H, Al-Herz W, ChatilaT, Crow YJ, Cunningham-Rundles C, Etzioni A, Franco JL, Holland SM, Klein C, Morio T, Ochs HD, Oksenhendler E, Puck J, Tang MLK, Tangye SG, Torgerson TR, Casanova JL, Sullivan KE. The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. J Clin Immunol. 2018 Jan;38(1):129-143. PubMed PMID: 29226301; PubMed Central PMCID:PMC5742599. 46. Sintes J, Gentile M, Zhang S, Garcia-Carmona Y, Magri G, Cassis L, Segura-Garzón D, Ciociola A, Grasset EK, Bascones S, Comerma L, Pybus M, Lligé D, Puga I, Gutzeit C, He B, DuBois W, Crespo M, Pascual J, Mensa A, Aróstegui JI, Juan M, Yagüe J, Serrano S, Lloreta J, Meffre E, Hahne M, Cunningham-Rundles C, Mock BA, Cerutti A. mTOR intersects antibody-inducing signals from TACI in marginal zone B cells. Nat Commun. 2018 ;8(1):1462. PubMed PMID: 29133782; PubMed Central PMCID: PMC5684130. 47.Feuille EJ, Anooshiravani N, Sullivan KE, Fuleihan RL, Cunningham-Rundles C. Autoimmune Cytopenias and Associated Conditions in CVID: a Report From the USIDNET Registry. J Clin Immunol. 2018 Jan;38(1):28-34. PubMed PMID: 29080979; PubMed Central PMCID: PMC5743637. 48.Gernez Y, Freeman AF, Holland SM, Garabedian E, Patel NC, Puck JM, Sullivan KE, Akhter J, Secord E, Chen K, Buckley R, Haddad E, Ochs HD, Fuleihan R, Routes J, Muskat M, Lugar P, Mancini J, Cunningham-Rundles C. Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):996-1001. 2017.06.041.PubMed PMID: 28939137; PubMed Central PMCID: PMC5858974. 49. Sng J, Ayoglu B, Chen JW, Schickel JN, Ferre EMN, Glauzy S, Romberg N, Hoenig M, Cunningham-Rundles C, Utz PJ, Lionakis MS, Meffre E. AIRE expression controls the peripheral selection of autoreactive B cells. Sci Immunol. 2019 50. Maglione PJ, Gyimesi G, Cols M, Radigan L, Ko HM, Weinberger T, Lee BH, Grasset EK, Rahman AH, Cerutti A, Cunningham-Rundles C. BAFF-driven B cell hyperplasia underlies lung disease in common variable immune deficiency JCI Insight. 2019 Mar 7;4(5). 51. Maffucci P, Bigio B, Rapaport F, Cobat A, Borghesi A, Lopez M, Patin E, Bolze A, Shang L, Bendavid M, Scott EM, Stenson PD, Cunningham-Rundles C, Cooper DN, Gleeson JG, Fellay J, Quintana-Murci L, Casanova JL, Abel L, Boisson B, Itan Y. Blacklisting variants common in private cohorts but not public data bases optimized human exome analysis. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):950-959. 1808403116. 2018 52. Cunningham-Rundles C. Common variable immune deficiency: dissection of the variable Immunol Rev. 2019 Jan;287(1):145-161. doi: 10.1111/imr.12728. PMID: 30565247 53. Filion CA, Taylor-Black S, Maglione PJ, Radigan L, Cunningham-Rundles C. Differentiation of Common Variable from IgG Deficiency: J Allergy Clin Immunol Pract. 2019 Apr;7(4):1277-1284.. 2018 Dec 14.PMID: 30557717 54. Maffucci P, Chavez J, Jurkiw TJ, O'Brien PJ, Abbott JK, Reynolds PR, Worth A, Notarangelo LD, Felgentreff K, Cortes P, Boisson B, Radigan L, Cobat A, Dinakar C, Ehlayel M, Ben-Omran T, Gelfand EW, Casanova JL, Cunningham-Rundles C. Biallelic mutations in DNA ligase underlie a spectrum of immune deficiencies. J Clin Invest. 2018 Dec 3;128(12):5489-5504. 55. Smith T, Cunningham-Rundles C. Primary B cell immune deficiencies Hum Immunol. 2019 Jun;80(6):351-362. PMID: 30359632 56. Garcia-Carmona Y, Ting AT, Radigan L, Athuluri Divakar SK, Chavez J, Meffre E, Cerutti A, Cunningham-Rundles C. TACI isoforms regulate Ligand Binding and Receptor Function. Front Immunol. 2018 Oct 2;9:2125. Recent Book Chapters: 1. Goldman-Cecil Medicine: Cunningham-Rundles C “Primary Immune Deficiency” 2018 2. Stiehm's Immune Deficiencies: Cunningham-Rundles C “Hypogammaglobulinemia and Common Variable Immunodeficiency” 3. Wiley Online Library: Cunningham-Rundles C “Antibody Deficiencies”; “Infections in the Compromised Host” Current Research Support: (continuous from the NIH since 1979) Principal Investigator: U24 AI086037 USIDNET Consortium “Resources for Investigators in Primary Immunodeficiency: 4/1/2015- 3/31/20 Principal Investigator: P01 AI061093 NIH/NIAID 08/31/17-08/30/22 “Cellular & Molecular Defects in Human B Cell Development” Principal Investigator: Project1: ”Development of B Cell Memory in CVID” 08/31/17-08/30/22 Principal Investigator: AI 0486930:”Targeting Primary Immunodeficiency among Minorities” 6/15/011-05/31/17 Completed Research Support • Principal Investigator: R18 AI048693 “Targeting Primary Immunodeficiency among Minorities” 06/15/04-05/31/10 • Principal Investigator: U24 AI086037 USIDNET Consortium “Resources for Investigators in Primary Immunodeficiency: 4/1/2010 - 3/31/15 • R34AI106570-01: Investigator: GLILD in CVID” 7/9/2014 - 7/8/2015 • Principal Investigator Chiron/Roche Corporation “IL-2 in Congenital T cell Defects” 12/31/08-12/30/10 • Principal Investigator Baxter BioScience “Using ICD codes to seek Immune Deficiency” 09/15/09-09/14/11 • Principal Investigator: P01 AI061093 NIH/NIAID 08/30/06 - 08/31/11 “Cellular & Molecular Defects in Human B Cell Development”

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