Isabelle Meyts, Belgium

University Hospitals Leuven, KU Leuven Pediatrics, Immunology, Microbiology and Transplantation
Isabelle Meyts obtained her medical degree at the University of Leuven, Belgium in 1999. In 2007 she obtained her license in Pediatrics as well as her PhD degree in 2007 with a work studying the role of Th subsets in allergic airway inflammation. At the University Hospitals Leuven, Belgium, in the Department of Pediatrics, she built the Pediatric Primary Immunodeficiency Unit and is responsible for the diagnosis and treatment of children affected by primary immunodeficiency. She has built expertise in hematopoietic stem cell transplantation for primary immunodeficiency. Her efforts led to the recognition of the Department of Primary Immunodeficiencies as a Jeffrey Modell Foundation Diagnostics and Research Center already in 2011. Her research centers on the genetic and functional unraveling of inborn errors of immunity. Recent focus has been on DADA2 and on various innate immune system disorders. In 2018 she was elected President of the European Society for Immunodeficiencies.

Presenter Of 3 Presentations

Optional Event No Topic Needed

WELCOME FROM ESID PRESIDENT

Lecture Time
17:45 - 17:50
Room
Bozar
Date
18.09.2019, Wednesday
Session Time
17:45 - 18:00
Presentation Topic
No Topic Needed
Parallel Session No Topic Needed

RECQL4: ON THE CROSSROADS OF IMMUNE DEFICIENCY AND CANCER: RTS AND RAPADILINO

Lecture Time
12:00 - 12:30
Room
Bozar
Date
19.09.2019, Thursday
Session Time
11:00 - 12:30
Presentation Topic
No Topic Needed
Poster Display Therapy

VACCINE COVERAGE AND SEROPROTECTION AGAINST MMR AND DTP IN IMMUNOCOMPROMISED CHILDREN

Lecture Time
10:39 - 10:40
Room
Poster Area
Date
20.09.2019, Friday
Session Time
10:00 - 17:00
Board Number
189
Presentation Topic
Therapy

Abstract

Background and Aims

Background: Vaccines are important to prevent life-threatening infectious diseases. This is also, and particularly, true for children with primary and secondary immunodeficiency who have an increased risk of complications and hospitalizations upon exposure to vaccine-preventable diseases. We aimed to measure vaccination coverage and seroprotection in children with primary immunodeficiencies (PID) and solid organ transplantation (SOT) in a university hospital in Flanders, Belgium.

Methods

Methods: Serological testing was performed on blood samples of 123 patients aged 2-16 years. Antibody titers were determined by ELISA (MMR) and multiplex assays (DTP) and were considered seropositive if above cut-off value. Vaccination status was assessed retrospectively by parental questionnaire. In particular, vaccination data were copied from relevant documents, verified against the Flemish vaccination register and missing data were requested from the general practitioner. Patients were considered fully vaccinated if they were correctly vaccinated according to the Flemish immunisation programme.

Results

Results: protection against vaccine-preventable diseases measles mumps rubella, diphteria, pertussis but not tetanus, is signficiantly lower in immunocompromised children, compared to historical data found in literature. This is true even in fully vaccinated children and in children on immunoglobulin substitution. Detailes follow at presentation.

Conclusions

Conclusion: Immunocompromised children remain at risk for vaccine preventable diseases. This is due to the nature of their disease and due to the immunosuppressive medication in SOT. Increasing the vaccination status of not only immunocompromised children, but also of healthy children to prevent circulation of vaccine-preventable diseases remains extremely important. The protective under IG substitution should be examined more in depth.

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Moderator Of 2 Sessions

Plenary Session
Room
Bozar
Date
18.09.2019, Wednesday
Session Time
18:00 - 19:00
Plenary Session
Room
Gold
Date
21.09.2019, Saturday
Session Time
12:30 - 13:15