Rajiv Mallick, United States of America
CSL Behring ImmunologyPresenter of 1 Presentation
BETTER SUBCUTANEOUS IMMUNOGLOBULIN (SCIG) TRAINING AND EFFICIENT INFUSIONS IMPROVE PATIENT-REPORTED TREATMENT OUTCOMES: RESULTS FROM AN IMMUNE DEFICIENCY FOUNDATION (IDF) SURVEY
Abstract
Background and Aims
Subcutaneous immunoglobulin (SCIG) is increasingly utilized in primary immunodeficiency (PID). Understanding patient treatment experiences is critical to improve outcomes. We analyzed Immune Deficiency Foundation (IDF) survey data to evaluate relationships between SCIG training, infusions, and patient-reported outcomes.
Methods
Multivariate logistic models identified predictors of high scores (top third) in Treatment Satisfaction Questionnaire for Medication (TSQM) domains (convenience, side effects, effectiveness, and global). Independent predictors were determined by backward selection of covariates significant in univariate analyses.
Results
Among 366 SCIG respondents, favorable training characteristics drove higher odds (p<0.05*, <0.01**) of being top third for TSQM domains including: convenience (confidence post-training: Odds Ratio [OR] = 3.0** and absence of training barriers: OR = 2.2*); side effects (confidence post-training: OR = 2.04*); effectiveness (no training barriers: OR = 2.4**); and global (trainer competence: OR = 3.5**). Efficient infusions increased odds of high TSQM domain scores: convenience (infusion preparation <20 minutes: OR = 1.95**); side effects (infusion preparation: OR = 1.88**, actual infusion: OR = 1.70*); and global (infusion preparation: OR = 1.76*). Age (<18 years) and treatment experience ≥ 2 years also increased odds of high TSQM domain scores. Compared with least favorable, those with most favorable training/infusion characteristics had higher predicted probabilities of high TSQM domain scores: (convenience, 55% vs 5%; side effects, 75% vs 5%; effectiveness, 44% vs 24%; global, 50% vs 7%).
Conclusions
Results suggest that improvements in SCIG training and infusion characteristics can drive better patient outcomes including convenience, reduced side effects, effectiveness and overall satisfaction.