Enrico Santangeli, Italy

University of Rome, Sapienza Department of Molecular Medicine
I am a 24 years old sixth year medical student at Sapienza University of Rome and i am about to get my medical degree. Since february 2018 I joined the" Centro regionale immunodeficienze primitive regione Lazio", the regional PIDs referral centre under the supervision of Prof. Quinti. I also had the opportunity to spend a 3 months long period in 2019 to work in freiburg alongside prof. Warnatz.

Presenter of 2 Presentations

 Conference Calendar
Working Party No Topic Needed

CASE 2

Lecture Time
08:00 - 08:15
Presenter
Room
Gold
Date
19.09.2019, Thursday
Session Time
07:45 - 08:45
Presentation Topic
No Topic Needed
Poster Display Malignancy and PID

GASTRIC CANCER INCIDENCE: A COMPARISON BETWEEN ITALIAN AND GERMAN COHORTS

Lecture Time
11:23 - 11:24
Presenter
Room
Poster Area
Date
20.09.2019, Friday
Session Time
10:00 - 17:00
Board Number
89
Presentation Topic
Malignancy and PID

Abstract

Background and Aims

Common Variable Immune Deficiency (CVID) is associated with an increased risk of malignancies, and in particular of gastric cancer. The aim of this study was to compare the incidence of gastric cancer in a German and an Italian CVID cohort.

Methods

Risk for cancers among 491 CVID German patients within a single centre cohort (CCI Freiburg) was compared to cancer incidence from the German Cancer Registry Database. Risk of cancer among 455 CVID Italian patients of three centres (Rome, Padua and Naples) was compared to cancer incidence from the Italian Cancer Registry Database.

Results

CVID patients showed an increased cancer incidence for all sites combined in the Italian cohort (Obs = 133, SIR = 2.4; 95%CI = 1.7–3.5),and in the German cohort (Obs = 20, SIR = 1.7 95%CI = 1.05–2.6). Gastric cancer in the Italian cohort (Obs = 25; SIR = 6.4; 95%CI = 3.2–12.5) and in the German cohort (Obs = 3, SIR = 7.9 95%CI = 1.6–23.0) were significantly increased with respect to the general population.

Conclusions

Despite the regional differences in the gastric cancer incidence in the general population between Italy and Germany, CVID patients carry a similar increased risk of gastric cancer in both cohorts. Additional studies aimed to identify major risk factors and prevention plans need to be established for the long-term follow up of CVID patients.

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