Diana M. Deleanu, Romania
Univ of Medicine & Pharm Iuliu Hatieganu Immunology and AllergyPresenter of 1 Presentation
CVID-ASSOCIATED TUMORS IN A ROMANIAN POPULATION
Abstract
Background and Aims
Common variable immunodeficiency disorder (CVID) is the most frequent and most diagnosed inborn errors of immunity. The deficiency of immune system increases the development of malignancies (either lymphomas, either other solid cancers). But multifactorial etiology, including virsal infections, chronic inflammation, or genetic background, contribute to tumor development.
The aim: We evaluate our patients with CIVD for developed tumors.
Methods
53 CVID patients were followed for 5 years.
Results
11 pts were diagnosed with malignancies lymphoma, leukemia, colorectal cancer, tyroid cancer). The most common neoplasia were lymphoma (in 6 pts).
Conclusions
The incidence of malignancy in our CVID cohort is high. Lymphomas were the most frequently diagnosed tumors. It is possible that a common causative or modifying gene variants pointed to errors in mechanisms may contribute to both immunodeficiency and malignancy.