Poster Display Therapy

PRIVIGEN, A NEW 10% LIQUID PREPARATION OF POLYVALENT HUMAN IGG FOR INTRAVENOUS ADMINISTRATION, CAUSES MORE HEADACHES IN PEDIATRIC PATIENTS THAN OTHER INTRAVENOUS IMMUNOGLOBULIN REPLACEMENT THERAPIES.

Lecture Time
10:53 - 10:54
Presenter
  • Jutte Van der Werff ten Bosch, Belgium
Room
Poster Area
Date
20.09.2019, Friday
Session Time
10:00 - 17:00
Board Number
205
Presentation Topic
Therapy

Abstract

Background and Aims

Introduction : Patients suffering from diseases associated with poor immunoglobulins levels or function can be helped with an immunoglobulin replacement therapy. These are often life-long therapies. Headaches are the most common adverse events of intravenous immunoglobulins. Multiple manufacturers make IV immunoglobulins, each having a proper manufacturing proces. This leads to a difference in tolerability.

Purpose : To investigate if the new IVIG Privigen causes more headaches in pediatric patients than other IVIG such as Nanogam, Multigam and Kiovig.

Methods

Material and methods : This is a retrospective study : in the first part, the data of the children treated with IVIG since 2008 will be studied. We will look for the incidence of headaches in relation to the used product. The second part of the study is a survey data collection. It will aim to evaluate their headaches during/before/after the treatment. Other adverse events such as fatigue, nausea and fever will also be evaluated.

Results

Results : 21.9% suffered from headaches with Privigen, 20.4% with non-Privigen IVIG. Only in 56.3% of the Privigen group and in 63.3% of the other group was there use of precautionary measures. There tend to be less headaches in patients getting higher dosis (p:0.045). Fatigue is the most common AE with 80.6% experiencing it. This was also the most invalidating AE, i.e. school absenteeism.

Conclusions

Conclusions : Privigen didn’t cause more headaches than the alternative IVIG products. On the other hand, fatigue is an important cause of morbidity in IVIG therapy. Precautionary measures should be used more.

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