The aim of this study is to expose the prevalence of neoplasms in patients diagnosed with Common Variable Immunodeficiency (CIVD) assisted at the Hospital das Clínicas da UFMG (HC-UFMG) and to elucidate the importance of specific investigation for lymphoproliferative complications.
Patients that were followed-up in the HC-UFMG Primary Immunodeficiency Service with diagnosis of CVID from January 1990 to April 2019 were selected. A retrospective study of neoplastic complications and their outcomes was performed.
Of the 120 patients with CVID in follow-up at our service, 7% evolved with neoplasms. Among these, 50% presented lymphoma, mainly B-cell lymphoma, 37.5% had gastric tumor and 12.5% had skin or thyroid neoplasia. In more than 75% of the exposed cases, good results were obtained.
Patients with CVID have different immunological profiles and heterogeneous phenotypes. One of the cost commonly found alteration is the decrease in B memory cells. The CVIDs have a high occurrence of malignancy explained by multifactorial factors. This fact leads to a worsening of the prognosis that requires an anticipation of the diagnosis of tumor implications. Thus, the institution of treatment is sought as soon as possible to improve the quality of life and avoid early mortality.