Introduction: Common Variable Immunodeficiency (CVID) is a heterogene group of disorders encompassed under a single term presented as autoimmunity, granulomatous disease, recurrent infections, and malignancy.
Objective: to present two cases of papillary thyroid carcinoma in adult with CVID.
Clinical cases:
Patient 1: Female 28 years, diagnosis of CVID in childhood, Freiburg IB phenotype, history of granulomatous disease and recurrent infections. At age 23 diagnosis of papillary thyroid carcinoma, total thyroidectomy and reactive iodine administration.
Patient 2: Female 38 years, diagnosis of CVID at 25 years, Freiburg IB phenotype, history of ITP, enteropathy associated with CVID, bronchiectasis and pulmonary fibrosis. At 37 years diagnosis of papillary thyroid carcinoma, treatment with total thyroidectomy and administration of radioactive iodine.
Discussion: prevalence of malignancy in CVID is 1.5.20.7%; occurs between 4th-6th decades of life; in these patients one of them differs.
The most frequent type of malignancy are non-Hodgkin's B-cell lymphomas, followed by gastric, bladder, breast and cervical epithelial tumors. Sporadic cases of papillary thyroid carcinoma have been reported, as in the López-Rocha cohort study in Mexico and in a study conducted by Sánchez in 2017 in the USA.
Of the risk factors found: female sex, high levels of IgM and ITP; In our cases, both female patients, only one with ITP, both IB group according to the Freiburg classification, none with high IgM levels.
Conclusions: it is important identify potential risk factors for malignancy in patients with CVID, since they have an increase of 5-12 times the risk than in the general population.