Poster Display Malignancy and PID

CVID-ASSOCIATED TUMORS IN A ROMANIAN POPULATION

Lecture Time
10:31 - 10:32
Presenter
  • Diana M. Deleanu, Romania
Room
Poster Area
Date
20.09.2019, Friday
Session Time
10:00 - 17:00
Board Number
32
Presentation Topic
Malignancy and PID

Abstract

Background and Aims

Common variable immunodeficiency disorder (CVID) is the most frequent and most diagnosed inborn errors of immunity. The deficiency of immune system increases the development of malignancies (either lymphomas, either other solid cancers). But multifactorial etiology, including virsal infections, chronic inflammation, or genetic background, contribute to tumor development.

The aim: We evaluate our patients with CIVD for developed tumors.

Methods

53 CVID patients were followed for 5 years.

Results

11 pts were diagnosed with malignancies lymphoma, leukemia, colorectal cancer, tyroid cancer). The most common neoplasia were lymphoma (in 6 pts).

Conclusions

The incidence of malignancy in our CVID cohort is high. Lymphomas were the most frequently diagnosed tumors. It is possible that a common causative or modifying gene variants pointed to errors in mechanisms may contribute to both immunodeficiency and malignancy.

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