Prof. Oliver Howes’ clinical work is as a Consultant Psychiatrist at the Maudsley Hospital, London, where he runs a general adult community mental health team. He heads the Psychiatric Imaging Group, which investigates the neurobiology of major mental illnesses and the development of novel treatments. It focuses on the translation of basic science findings into first-in-human and early phase clinical studies. The group’s preclinical work involves the development of novel radiotracers and pharmacological probes to take into human studies, and the development of preclinical models of the neurobiology of major mental illnesses. Prof. Howes has made a major contribution to the neurobiological understanding of schizophrenia by identifying a subtype of schizophrenia that does not show elevated dopamine synthesis.