In March 2020, the World Health Organization (WHO) declared the COVID-19 virus (known as Coronavirus) a global pandemic leading to almost ubiquitous public health restrictive measures. Both the COVID-19 pandemic and the applied restrictive measures can have marked acute and long-term detrimental effects on physical and mental health-related quality of life and every-day functioning of the general population, but also in particular in specific population groups. Thus, apart from the actual COVID-19-infection-related health complications, indirect physical and mental health complications might represent the most crucial and still unpredictable public-health-related aspect of the pandemic and call for a careful assessment at a global level. The Collaborative Outcomes study on Health and Functioning during Infection Times (COH-FIT) is the currently largest-scale global study on the overall health impact of the COVID-19 pandemic and applied restrictive measures in the general population, representing a unique collaboration between over 200 researchers, across over 40 countries and six continents. The elaborated design of the COH-FIT study can identify non-modifiable and modifiable multisystem risk and resilience factors in such an unprecedented time. Results will inform and facilitate acute and long-term interventions and preventive responses at a policy, health care and individual level, to better adapt to challenges inflicted by the ongoing pandemic and possible future global crises. This symposium presents the project background and methodology and offers an overview of the most important results of the global COH-FIT sample of over 80,000 in adult, adolescent and children participants.