J. Bolanos, Spain

University of Salamanca Institute of Functional Biology and Genomics
Juan P. BolaƱos studied Pharmacy at the University of Salamanca (USAL, Spain), where he performed the PhD in Biochemistry & Molecular Biology. The he moved to the Institute of Neurology (London, UK) as an EU-funded Marie Curie Postdoc. He returned to USAL and became lecturer, and then full professor (2005). He received a Marie Curie Excellence Award and has been funded from Spanish, EU and NIH institutions. He is associated editor in several journals and organized a dozen of international conferences. He was the president of the European Society for Neurochemistry. His is interested in the regulation of the metabolic and redox coupling amongst the brain cells and its impact in behavior and neurological diseases. He identified nitric oxide as a regulator of mitochondrial cytochrome c oxidase, deciphered key signaling pathways regulating glycolysis in astrocytes and neurons and characterized structural features of the mitochondrial respiratory chain in these cells as key factors dictating energy provision for neurotransmission. He described that mitochondrial reactive oxygen species (mROS) in astrocytes are essential physiological signals in brain metabolism and behavior. In collaboration with G. Marsicano (Bordeaux) we recently identified that cannabinoids act on mitochondrial receptors to regulate astrocytic mROS and glucose metabolism affecting sociability.

Moderator Of 1 Session

Date
Sun, 11.04.2021
Session Time
17:30 - 19:00
Room
Channel 4
Session Description
The Live Q&A of this session will take place in the Live Sessions auditorium. Please refer to the interactive programme for the exact time and channel.

This symposium will discuss a) novel mechanisms of CNS and peripheral metabolic function (insulin resistance, the mitochondrial pathway of epigenetic regulation of neuroplasticity, neuropeptides) in cross-species models; b) the crosstalk between glial cells and neurons in the regulation of neuroplasticity and c) the need for integrated system-level strategies to identify and more effectively treat biologically based subtypes of depressive disorders and block the progression to dementia. New data of brain-enriched exosomes will also be presented as a new frontier to study in-vivo CNS molecular mechanisms in humans. Pierre Magistretti will present new data on the role of neuron-glia metabolic coupling in neuronal plasticity and neuropsychiatric disorders pointing to a novel action of L-lactate as a signaling molecule in addition to its role as an energy substrate. Carla Nasca (presenter) will present new data on the role of exosomes in psychiatric disorders and the emerging role of mitochondria as regulators of epigenetic programming of neuroplasticity in depressive disorders and rodent models. Aleksander Mathe will discuss the impact of targeting neuropeptide Y pathways in depressive disorders and post-traumatic stress disorder and present both preclinical and clinical data. Natalie Rasgon (chair and presenter) will describe conceptual model of the panel as a unique translational platform for studies of metabolic phenotypes in the progression from depressive disorders to dementia.

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Pre-Recorded with Live Q&A

Presenter Of 2 Presentations

Symposium: Epigenetic and Metabolic Mechanisms of Brain Plasticity for Personalised Interventions in Neuropsychiatric Disorders (ID 232) No Topic Needed
Symposium: Epigenetic and Metabolic Mechanisms of Brain Plasticity for Personalised Interventions in Neuropsychiatric Disorders (ID 232) No Topic Needed

Role of Neuron-glia Metabolic Coupling Mediated by Mitochondrial Cannabinoid Receptors in Pathological Behaviours

Session Icon
Pre-Recorded with Live Q&A
Date
Sun, 11.04.2021
Session Time
17:30 - 19:00
Room
Channel 4
Lecture Time
18:04 - 18:21
Presenter