A. Sidenkova, Russian Federation
Ural State Medical University PsychiatryPresenter of 5 Presentations
EPV0343 - The structure of the cognitive reserve in Alzheimer's disease
ABSTRACT
Introduction
Alzheimer's disease is common among the modern population. Emotional support for caregivers and a stable social role contribute to the maintenance of cognitive resources in Alzheimer's.
Objectives
To investigate the protective mechanisms that protect the brain from premature aging
Methods
clinical, sociological
Results
Violations of the higher cerebral functions of speech, gnosis, praxis are the neuropsychological basis for the development of psychological symptoms of dementia. Speech disorders, gnosis disorders contribute to the formation of painful ideas, perception disorders, eating disorders and affective symptoms. The level of functional activity is low and does not depend on the state of severe microsocial dementia, total aphasia and apraxia. The social, work, family and marital status of caregivers for patients with moderate to severe dementia is declining. An increase in the degree of dementia can reduce the functional activity of the caregiver. Caregivers often suffer from neurotic, affective and other mental disorders. A person with dementia plays a subordinate role in the family. Changing roles in the family occurs when the patient has delusion, agitation / aggression, anxiety, unstable mood / irritability. In these cases, the interpersonal distance in the “care-patient” pair increases. Caregivers have a high level of emotional involvement in the care process. A change in the role of the family, a change in place of residence, and a high level of “expressive” emotions of the guardian negatively affect the formation of psychosis, anxiety and aberrant behavior in patients with dementia. Microsocial factors influence cognitive retention in dementia
Conclusions
Protective psychosocial factors strengthen the cognitive reserve
EPV0344 - Study of changes in neuropsychological indicators in adults
ABSTRACT
Introduction
Currently, the number of cases of pathological aging of the CNS, represented by a violation of cognitive functions, is increasing. But there is a social request to prolong the physical and mental activity of older people
Objectives
The study of the dynamics of cognitive aging is timely and relevant.
The article contains a report on a cohore non-repeating study of higher brain functions at various age periods
Methods
The average age was 45.1 + 5.7 years.
Inclusion criteria: 1. Dextral.
Non-inclusion criteria:
1. Clinically significant somatic diseases in their medical history.
2. Mental disorders in their medical history.
•Applied neuropsychological, statistical research methods. The research tool was the neuropsychological rapid method including the subtests:
•“Memorizing 9 words in three presentations (1st, 2nd, 3rd attempts)”,
•“Sequential subtraction ",
•" Test "of Benton's visual memory",
•"Solving an arithmetic problem",
•"Overlaid images",
•"Specified flow of associations in 1 minute",
• "Figure of 3 geometric figures",
• "Blind hours",
• "Graph-motor test",
"Delay word reproduction"
Results
The first cohort 27–40 years old. The second cohort 41–50 years old.Third cohort 51 years old and older. A significant difference in the performance of the graphomotor test between the subjects of the age subgroup of 27-40 years and the subgroup of 41-50 years was statistically confirmed. In older people revealed a much greater number of errors, interruptions of the test than the representatives of the more "young" subgroup
Conclusions
The deterioration in the performance of the graphomotor test was the most age-specific
EPV0393 - Evaluation of the function of the hippocampus at the preoperative stage of cardiac surgery as a harbinger of postoperative psychosis
ABSTRACT
Introduction
Development of an acute cerebral dysfunction in a form of delirium after cardiac surgeries is common general medical problem that associated with prolonged hospital stay after the surgery, risk of development of infection, risk of subsequent neurocognitive changes, and postoperative morbidity
Objectives
to compare risk of development of postoperative delirium in elderly patients with and without hippocampal dysfunction
Methods
selective observational longitudinal study of the same group of objects in pre and postoperative period
Results
For the diagnosis of degenerative process in CNS on early stages Free and cued selective reminding test immediate recall (FCSRT-IT) was shown to be the most sensitive. Based on learning of verbal material and semantic cues with recalling, FCSRT-IT allows differentiating amnestic disturbances hippocampal type from secondary disturbances of memory due to neurodynamic changes
Conclusions
Hippocampal dysfunction is a factor of developing of postoperative delirium in elderly patients that requires using additional measures in patients with mild cognitive disturbance to prevent developing of postoperative delirium
O161 - The psychosocial factors in the formation of symptoms of dementia
ABSTRACT
Introduction
The growing prevalence of severe cognitive impairment in populations, the involvement of a significant number of people of working age in the medical, psychological and social problems associated with dementia, the insufficiency and inconsistency of information about the mechanisms of formation of these disorders actualize a comprehensive social study of dementia.
Objectives
the psychosocial mechanisms of the formation of clinical, functional disorders in dementia, to develop comprehensive medical and psychosocial programs to help patients with dementia and those involved in caring for them, based on the proposals of the psychosocial model of dementia
Methods
A selective observational comparative dynamic study of 315 people with Alzheimer's dementia and 214 people who care for the patients was carried out.
Results
Changes in family-role and social parameters, a high level of “expressed” emotions of caregivers have an adverse effect on the development of psychotic (r = 0.618), affective (r = 0.701), behavioral (r = 0.837) dementia disorders. The degree of adherence to anti-dementia therapy by the caregiver is one of the important factors determining the amount of care received by the patient (r = 0.698). Agitation / aggression (r = 0.761), anxiety (r = 0.562), sleep disturbances (r = 0.521) contribute to increased compliance. The low satisfaction of the caregiver with premorbid (r = 0.698) and current (r = 0.653) relationships with the patient leads to a decrease in the compliance of the caregiver.
Conclusions
The mechanism of psychopathological symptoms, functional disorders is heterogeneous, depending on the biological causes and psychosocial conditions of functioning of patients.
O185 - Correlation of neurotrophic and neuropsychological parameters in Alzheimer's disease
ABSTRACT
Introduction
Alzheimer's disease (AD) is a neurodegenerative pathology that develops mainly in elderly and senile people.
Disruption of BDNF transport or suppression of its production appears to be typical for people of old age.
Objectives
Objective: To investigate the influence of Alzheimer's disease on the secretion of brain factors and correlate with neuropsychological profiles.
Methods
12 men (2) and women (10) with Alzheimer's disease were examined. The average age of the subjects was 76.25 + 4.89. Methods: MMSE, ADAS-COG, laboratory - BDNF was performed using the G7611 BDNF Emax (R) ImmunoAssaySystem 5 x 96 wells, BDNF Emax® Immunological test.
Results
2 patients have mild dementia, 8 patients have moderate dementia, 2 patients have severe dementia. The average age of patients with mild dementia was 72.0 + 1.0. The average MMSE score is 16.7 + 3.4. Correlation analysis showed a close relationship between a pronounced decrease in memory in memory tests (ADAS-COG) and a pronounced decrease in blood BDNF content (r = 0.676). A close statistically significant relationship was found between a low result of the recognition test and a low blood BDNF content (r = 0.598).
Conclusions
we assume that blood BDNF is a marker of pathologically accelerated aging of the central nervous system, since low test results for mnestic function are an indicator of severe degeneration in Alzheimer's disease