A. Sidenkova, Russian Federation

Ural State Medical University Psychiatry

Presenter of 5 Presentations

e-Poster Viewing (ID 1107) AS18. Intellectual Disability

EPV0343 - The structure of the cognitive reserve in Alzheimer's disease

Session Name
e-Poster Viewing (ID 1107)
Date
Sun, 11.04.2021
Session Time
07:30 - 23:59
Room
e-Poster Gallery
Lecture Time
07:30 - 07:30

ABSTRACT

Introduction

Alzheimer's disease is common among the modern population. Emotional support for caregivers and a stable social role contribute to the maintenance of cognitive resources in Alzheimer's.

Objectives

To investigate the protective mechanisms that protect the brain from premature aging

Methods

clinical, sociological

Results

Violations of the higher cerebral functions of speech, gnosis, praxis are the neuropsychological basis for the development of psychological symptoms of dementia. Speech disorders, gnosis disorders contribute to the formation of painful ideas, perception disorders, eating disorders and affective symptoms. The level of functional activity is low and does not depend on the state of severe microsocial dementia, total aphasia and apraxia. The social, work, family and marital status of caregivers for patients with moderate to severe dementia is declining. An increase in the degree of dementia can reduce the functional activity of the caregiver. Caregivers often suffer from neurotic, affective and other mental disorders. A person with dementia plays a subordinate role in the family. Changing roles in the family occurs when the patient has delusion, agitation / aggression, anxiety, unstable mood / irritability. In these cases, the interpersonal distance in the “care-patient” pair increases. Caregivers have a high level of emotional involvement in the care process. A change in the role of the family, a change in place of residence, and a high level of “expressive” emotions of the guardian negatively affect the formation of psychosis, anxiety and aberrant behavior in patients with dementia. Microsocial factors influence cognitive retention in dementia

Conclusions

Protective psychosocial factors strengthen the cognitive reserve

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e-Poster Viewing (ID 1107) AS18. Intellectual Disability

EPV0344 - Study of changes in neuropsychological indicators in adults

Session Name
e-Poster Viewing (ID 1107)
Date
Sun, 11.04.2021
Session Time
07:30 - 23:59
Room
e-Poster Gallery
Lecture Time
07:30 - 07:30

ABSTRACT

Introduction

Currently, the number of cases of pathological aging of the CNS, represented by a violation of cognitive functions, is increasing. But there is a social request to prolong the physical and mental activity of older people

Objectives

The study of the dynamics of cognitive aging is timely and relevant.

The article contains a report on a cohore non-repeating study of higher brain functions at various age periods

Methods

The average age was 45.1 + 5.7 years.

Inclusion criteria: 1. Dextral.

Non-inclusion criteria:

1. Clinically significant somatic diseases in their medical history.

2. Mental disorders in their medical history.

•Applied neuropsychological, statistical research methods. The research tool was the neuropsychological rapid method including the subtests:

•“Memorizing 9 words in three presentations (1st, 2nd, 3rd attempts)”,

•“Sequential subtraction ",

•" Test "of Benton's visual memory",

•"Solving an arithmetic problem",

•"Overlaid images",

•"Specified flow of associations in 1 minute",

• "Figure of 3 geometric figures",

• "Blind hours",

• "Graph-motor test",

"Delay word reproduction"

Results

The first cohort 27–40 years old. The second cohort 41–50 years old.Third cohort 51 years old and older. A significant difference in the performance of the graphomotor test between the subjects of the age subgroup of 27-40 years and the subgroup of 41-50 years was statistically confirmed. In older people revealed a much greater number of errors, interruptions of the test than the representatives of the more "young" subgroup

Conclusions

The deterioration in the performance of the graphomotor test was the most age-specific

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e-Poster Viewing (ID 1107) AS23. Neuroscience in Psychiatry

EPV0393 - Evaluation of the function of the hippocampus at the preoperative stage of cardiac surgery as a harbinger of postoperative psychosis

Session Name
e-Poster Viewing (ID 1107)
Date
Sun, 11.04.2021
Session Time
07:30 - 23:59
Room
e-Poster Gallery
Lecture Time
07:30 - 07:30

ABSTRACT

Introduction

Development of an acute cerebral dysfunction in a form of delirium after cardiac surgeries is common general medical problem that associated with prolonged hospital stay after the surgery, risk of development of infection, risk of subsequent neurocognitive changes, and postoperative morbidity

Objectives

to compare risk of development of postoperative delirium in elderly patients with and without hippocampal dysfunction

Methods

selective observational longitudinal study of the same group of objects in pre and postoperative period

Results

For the diagnosis of degenerative process in CNS on early stages Free and cued selective reminding test immediate recall (FCSRT-IT) was shown to be the most sensitive. Based on learning of verbal material and semantic cues with recalling, FCSRT-IT allows differentiating amnestic disturbances hippocampal type from secondary disturbances of memory due to neurodynamic changes

Conclusions

Hippocampal dysfunction is a factor of developing of postoperative delirium in elderly patients that requires using additional measures in patients with mild cognitive disturbance to prevent developing of postoperative delirium

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Oral Communications (ID 1110) AS18. Intellectual Disability

O161 - The psychosocial factors in the formation of symptoms of dementia

Date
Sat, 10.04.2021
Session Time
07:00 - 21:00
Room
On Demand
Lecture Time
07:12 - 07:24

ABSTRACT

Introduction

The growing prevalence of severe cognitive impairment in populations, the involvement of a significant number of people of working age in the medical, psychological and social problems associated with dementia, the insufficiency and inconsistency of information about the mechanisms of formation of these disorders actualize a comprehensive social study of dementia.

Objectives

the psychosocial mechanisms of the formation of clinical, functional disorders in dementia, to develop comprehensive medical and psychosocial programs to help patients with dementia and those involved in caring for them, based on the proposals of the psychosocial model of dementia

Methods

A selective observational comparative dynamic study of 315 people with Alzheimer's dementia and 214 people who care for the patients was carried out.

Results

Changes in family-role and social parameters, a high level of “expressed” emotions of caregivers have an adverse effect on the development of psychotic (r = 0.618), affective (r = 0.701), behavioral (r = 0.837) dementia disorders. The degree of adherence to anti-dementia therapy by the caregiver is one of the important factors determining the amount of care received by the patient (r = 0.698). Agitation / aggression (r = 0.761), anxiety (r = 0.562), sleep disturbances (r = 0.521) contribute to increased compliance. The low satisfaction of the caregiver with premorbid (r = 0.698) and current (r = 0.653) relationships with the patient leads to a decrease in the compliance of the caregiver.

Conclusions

The mechanism of psychopathological symptoms, functional disorders is heterogeneous, depending on the biological causes and psychosocial conditions of functioning of patients.

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Oral Communications (ID 1110) AS23. Neuroscience in Psychiatry

O185 - Correlation of neurotrophic and neuropsychological parameters in Alzheimer's disease

Date
Sat, 10.04.2021
Session Time
07:00 - 21:00
Room
On Demand
Lecture Time
10:48 - 11:00

ABSTRACT

Introduction

Alzheimer's disease (AD) is a neurodegenerative pathology that develops mainly in elderly and senile people.

Disruption of BDNF transport or suppression of its production appears to be typical for people of old age.

Objectives

Objective: To investigate the influence of Alzheimer's disease on the secretion of brain factors and correlate with neuropsychological profiles.

Methods

12 men (2) and women (10) with Alzheimer's disease were examined. The average age of the subjects was 76.25 + 4.89. Methods: MMSE, ADAS-COG, laboratory - BDNF was performed using the G7611 BDNF Emax (R) ImmunoAssaySystem 5 x 96 wells, BDNF Emax® Immunological test.

Results

2 patients have mild dementia, 8 patients have moderate dementia, 2 patients have severe dementia. The average age of patients with mild dementia was 72.0 + 1.0. The average MMSE score is 16.7 + 3.4. Correlation analysis showed a close relationship between a pronounced decrease in memory in memory tests (ADAS-COG) and a pronounced decrease in blood BDNF content (r = 0.676). A close statistically significant relationship was found between a low result of the recognition test and a low blood BDNF content (r = 0.598).

Conclusions

we assume that blood BDNF is a marker of pathologically accelerated aging of the central nervous system, since low test results for mnestic function are an indicator of severe degeneration in Alzheimer's disease

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