The work of psychiatrists has been profoundly disrupted by the COVID-19 pandemic (e.g., redeployment, shifting institutional priorities, sudden massive use of telehealth services). At the same time, mental health concerns in the population have been exacerbated by the pandemic (e.g., due to isolation, anxiety, substance use), resulting in increased need for services at a time when accessing services is more difficult. This symposium will present the results of two large longitudinal studies that speak to these issues. The first is a global, multilingual study of the impact of the COVID-19 pandemic on clinical practice and well-being of psychiatrists and other mental health professionals. Results will be presented from two waves of data collection with members of the World Health Organization's Global Clinical Practice Network (GCPN), comprising 15,500 clinicians from 159 countries. The first speaker will focus on predictors of distress, occupational burnout, and practice disruption over time and the use of distance technologies for evaluation and treatment. The second and third speakers will focus on China and Russia, examining impact on GCPN members as a function of the course of the pandemic in those countries. The fourth speaker will focus on the mental health impact of the COVID-19 pandemic among a representative sample of the general population of Madrid (n = 900), interviewed by telephone at two time points. The symposium will consider the implications of the results for the delivery of mental health services and for programs and policies that protect well-being and reduce occupational burnout among psychiatrists.