Ömercan Topaloğlu (Turkey)
Kocaeli Derince Training and Research Hospital EndocrinologyAuthor of 1 Presentation
HYPOPARATHYROID PREGNANCY: RETROSPECTIVE ANALYSIS OF TWENTY CASES
Abstract
Background and Aims
Hypoparathyroidism is a relatively uncommon medical disorder in pregnancy, and, if diagnosed before pregnancy, it should be managed before conception. We aimed to reveal the clinical and laboratory features of pregnant women with permanent hypoparathyroidism.
Methods
We retrospectively analyzed the pregnant women with permanent hypoparathyroidism and without any comorbid illness. Age, gravida, parity, etiology and duration of hypoparathyroidism, medications, and laboratory tests, history of previous hypoparathyroid pregnancy, gestational diabetes mellitus, hospitalization due to hypocalcemia, follow-up, severe hypocalcemia at least once in pregnancy (corrected Ca(CCa)<7.5 mg/dL) were analyzed.
Results
Mean age of the patients(n=20) was 35.10(±4.83). Mean duration of hypoparathyroidism was 74.55 months. Only 1 patient had idiopathic hypoparathyroidism. Severe hypocalcemia was detected in 55%(n=11) in total, and in only 25%(n=1) of 4 patients who did not use calcitriol in pregnancy. In pregnancy, 80%(n=16) of the patients used calcitriol, 40%(n=8) cholecalciferol, 65%(n=13) calcium carbonate, and 20%(n=4) magnesium. Two patients left off calcitriol and used only CaCO3 when became pregnant. Calcitriol dosage was higher in 3rd trimester of pregnancy comparing to pregestational period(p=0.001), but no change was found in CaCO3 dosage, CCa or phosphorus level.
Conclusions
To our knowledge, our study is the first to analyze such a high number of pregnant women with hypoparathyroidism. Biochemical hypocalcemia may frequently be observed in pregnancy with hypoparathyroidism. We recommend delicate dose adjustment based on the clinical background.
Presenter of 1 Presentation
HYPOPARATHYROID PREGNANCY: RETROSPECTIVE ANALYSIS OF TWENTY CASES
Abstract
Background and Aims
Hypoparathyroidism is a relatively uncommon medical disorder in pregnancy, and, if diagnosed before pregnancy, it should be managed before conception. We aimed to reveal the clinical and laboratory features of pregnant women with permanent hypoparathyroidism.
Methods
We retrospectively analyzed the pregnant women with permanent hypoparathyroidism and without any comorbid illness. Age, gravida, parity, etiology and duration of hypoparathyroidism, medications, and laboratory tests, history of previous hypoparathyroid pregnancy, gestational diabetes mellitus, hospitalization due to hypocalcemia, follow-up, severe hypocalcemia at least once in pregnancy (corrected Ca(CCa)<7.5 mg/dL) were analyzed.
Results
Mean age of the patients(n=20) was 35.10(±4.83). Mean duration of hypoparathyroidism was 74.55 months. Only 1 patient had idiopathic hypoparathyroidism. Severe hypocalcemia was detected in 55%(n=11) in total, and in only 25%(n=1) of 4 patients who did not use calcitriol in pregnancy. In pregnancy, 80%(n=16) of the patients used calcitriol, 40%(n=8) cholecalciferol, 65%(n=13) calcium carbonate, and 20%(n=4) magnesium. Two patients left off calcitriol and used only CaCO3 when became pregnant. Calcitriol dosage was higher in 3rd trimester of pregnancy comparing to pregestational period(p=0.001), but no change was found in CaCO3 dosage, CCa or phosphorus level.
Conclusions
To our knowledge, our study is the first to analyze such a high number of pregnant women with hypoparathyroidism. Biochemical hypocalcemia may frequently be observed in pregnancy with hypoparathyroidism. We recommend delicate dose adjustment based on the clinical background.