Nawar Dalila (Denmark)
Rigshospitalet Department of Clinical Biochemistry, Section for Molecular GeneticsPresenter of 1 Presentation
O015 - Plasma TSH Concentration and Risk of Cardiovascular Disease: A Mendelian Randomization Study of 105,224 Individuals from The General Population. (ID 210)
Abstract
Background and Aims
In observational studies, the association between plasma concentration of thyroid stimulating hormone (TSH) and cardiovascular disease outcomes is conflicting. Using Mendelian randomization, we tested the hypothesis that plasma TSH concentration is associated with risk of ischemic heart disease (IHD), myocardial infarction (MI), and atrial fibrillation (AF).
Methods
In a prospective cohort study of the general population, The Copenhagen General Population Study, including 105,224 individuals, we first tested whether plasma TSH concentration was associated observationally with risk of incident IHD, MI, and AF (=positive control). Subsequently, we tested the genetic association between an allele score weighted on plasma TSH concentrations and risk of the same endpoints.
Results
During a median follow-up of 7 years (0-13 years), 5,425 developed IHD, 2,148 had an incident MI, and 5,105 developed AF. Observationally, using multifactorially adjusted restricted cubic splines, low plasma TSH concentrations (<1.53mIU/L=median) were associated with an increased risk of IHD, MI, and AF. Hazard ratios (HR) increased gradually with lower TSH concentrations up to 1.11(0.99-1.23) for IHD, 1.22(1.03-1.43) for MI, and 1.22(1.10-1.35) for AF, comparing individuals with TSH concentrations in the lowest 5th (≤0.54mIU/L) versus >25th (>1.04mIU/L) percentile (=reference). In genetic analyses, comparing individuals with a gene score ≤5th percentile (who had 16% lower TSH concentrations), versus individuals with a gene score >50th percentile (=reference), HRs were 1.13(1.00-1.28) for IHD, 1.29(1.07-1.55) for MI, and 1.15(1.02-1.31) for AF.
Conclusions
Low plasma TSH concentrations are associated observationally and genetically with an increased risk of IHD, MI, and AF in the general population.
Presenter of 1 Presentation
O015 - Plasma TSH Concentration and Risk of Cardiovascular Disease: A Mendelian Randomization Study of 105,224 Individuals from The General Population. (ID 210)
Abstract
Background and Aims
In observational studies, the association between plasma concentration of thyroid stimulating hormone (TSH) and cardiovascular disease outcomes is conflicting. Using Mendelian randomization, we tested the hypothesis that plasma TSH concentration is associated with risk of ischemic heart disease (IHD), myocardial infarction (MI), and atrial fibrillation (AF).
Methods
In a prospective cohort study of the general population, The Copenhagen General Population Study, including 105,224 individuals, we first tested whether plasma TSH concentration was associated observationally with risk of incident IHD, MI, and AF (=positive control). Subsequently, we tested the genetic association between an allele score weighted on plasma TSH concentrations and risk of the same endpoints.
Results
During a median follow-up of 7 years (0-13 years), 5,425 developed IHD, 2,148 had an incident MI, and 5,105 developed AF. Observationally, using multifactorially adjusted restricted cubic splines, low plasma TSH concentrations (<1.53mIU/L=median) were associated with an increased risk of IHD, MI, and AF. Hazard ratios (HR) increased gradually with lower TSH concentrations up to 1.11(0.99-1.23) for IHD, 1.22(1.03-1.43) for MI, and 1.22(1.10-1.35) for AF, comparing individuals with TSH concentrations in the lowest 5th (≤0.54mIU/L) versus >25th (>1.04mIU/L) percentile (=reference). In genetic analyses, comparing individuals with a gene score ≤5th percentile (who had 16% lower TSH concentrations), versus individuals with a gene score >50th percentile (=reference), HRs were 1.13(1.00-1.28) for IHD, 1.29(1.07-1.55) for MI, and 1.15(1.02-1.31) for AF.
Conclusions
Low plasma TSH concentrations are associated observationally and genetically with an increased risk of IHD, MI, and AF in the general population.