Andrew O. Agbaje (Finland)
University of Eastern Finland Institute of Public Health and Clinical Nutrition, Faculty of Health SciencesAuthor Of 2 Presentations
Live Q&A (ID 1551)
O058 - Association of carotid-femoral pulse wave velocity and carotid intima-media thickness with cardiometabolic risks among young adults: The ALSPAC study (ID 1452)
Abstract
Background and Aims
It is well established that metabolic dysfunction alters vascular properties. However little is known about the reverse association i.e, whether vascular profile independently predicts increased cardiometabolic risks. We investigated the cross-sectional associations of carotid-femoral pulse wave velocity (cfPWV), a measure of arterial stiffness, and carotid intima-media thickness (cIMT) with metabolic risks in young adulthood.
Methods
We studied 1799 British 24.5-year-olds (62% females). cfPWV was measured by Vicorder device and cIMT by CardioHealth ultrasound scan. Insulin, glucose, lipid profile, and high sensitivity C-reactive protein were measured during a fasting state according to standard protocols. Using multivariable linear regressions we adjusted for age, sex, systolic blood pressure, heart rate, moderate to vigorous physical activity, smoking status, family history of cardiometabolic diseases, dual-energy Xray absorptiometry measured fat mass and lean mass, and other metabolic and inflammatory markers.
Results
cfPWV was directly and independently associated with fasting insulin concentration [β = 0.202 (CI: 0.045 to 0.360); p=0.012] and fasting plasma glucose [β = 0.656 (0.116 to 1.196); p=0.017]. cfPWV was not associated with low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and high sensitivity C-reactive protein. cIMT was not associated with cardiometabolic and inflammatory markers.
Conclusions
These findings suggest that increased arterial stiffness independently associates with higher fasting insulin and glucose concentration in 24.5-year-olds. However, cIMT was unrelated to cardiometabolic risks. Future studies could examine the longitudinal associations of vascular properties in early life with cardiometabolic risks in adulthood.
Presenter of 2 Presentations
Live Q&A (ID 1551)
O058 - Association of carotid-femoral pulse wave velocity and carotid intima-media thickness with cardiometabolic risks among young adults: The ALSPAC study (ID 1452)
Abstract
Background and Aims
It is well established that metabolic dysfunction alters vascular properties. However little is known about the reverse association i.e, whether vascular profile independently predicts increased cardiometabolic risks. We investigated the cross-sectional associations of carotid-femoral pulse wave velocity (cfPWV), a measure of arterial stiffness, and carotid intima-media thickness (cIMT) with metabolic risks in young adulthood.
Methods
We studied 1799 British 24.5-year-olds (62% females). cfPWV was measured by Vicorder device and cIMT by CardioHealth ultrasound scan. Insulin, glucose, lipid profile, and high sensitivity C-reactive protein were measured during a fasting state according to standard protocols. Using multivariable linear regressions we adjusted for age, sex, systolic blood pressure, heart rate, moderate to vigorous physical activity, smoking status, family history of cardiometabolic diseases, dual-energy Xray absorptiometry measured fat mass and lean mass, and other metabolic and inflammatory markers.
Results
cfPWV was directly and independently associated with fasting insulin concentration [β = 0.202 (CI: 0.045 to 0.360); p=0.012] and fasting plasma glucose [β = 0.656 (0.116 to 1.196); p=0.017]. cfPWV was not associated with low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride and high sensitivity C-reactive protein. cIMT was not associated with cardiometabolic and inflammatory markers.
Conclusions
These findings suggest that increased arterial stiffness independently associates with higher fasting insulin and glucose concentration in 24.5-year-olds. However, cIMT was unrelated to cardiometabolic risks. Future studies could examine the longitudinal associations of vascular properties in early life with cardiometabolic risks in adulthood.