Christina Christoffersen (Denmark)

Rigshospitalet Clinical Biochemistry

Author Of 1 Presentation

O020 - Association of the apolipoprotein M and sphingosine-1-phosphate complex with brown adipose tissue after cold exposure in humans (ID 1184)

Session Type
Rapid Fire Session
Session Time
16:00 - 17:30
Date
Mon, 31.05.2021
Room
Hall F
Lecture Time
16:18 - 16:23

Abstract

Background and Aims

The HDL-associated apolipoprotein M (apoM) and its ligand sphingosine-1-phosphate (S1P) may control energy metabolism, as supported by apoM-deficient mice showing a favorable metabolic phenotype with increased triglyceride turnover and protection against obesity-induced insulin resistance. In addition, apoM deficiency is associated with increased vascular permeability and brown adipose tissue (BAT) mass and activity, and these effects are partly mediated by the S1P receptor 1.

Methods

In the current study, we explored the connection between plasma apoM/S1P levels and parameters of BAT as measured via 18F-FDG PET/CT after cold exposure using three different protocols in humans.

Results

Fixed (n=15) vs personalized (n=20) short-term cooling protocols decreased and increased apoM (-8.4%, p=0.032 vs 15.7%, p<0.0005) and S1P (-41.0%, p<0.0005 vs 19.1%, p<0.005) plasma levels, respectively. Long-term cooling (n=44) had no effect on plasma apoM or S1P levels. Plasma apoM and S1P did not correlate significantly to BAT volume and activity in the individual study using fixed or personalized cooling protocols. The short-term studies combined, showed that increased changes in plasma apoM correlated with BAT volume (β:0.39, 95% CI [-0.01-0.78], P=0.054) and metabolic activity (β:0.44, 95% CI [0.06-0.81], P=0.024) after adjusting for study design.

Conclusions

Plasma apoM and S1P levels are altered in response to cold exposure and may be linked to changes in BAT metabolic activity and volume. Our results highlight a possible role of the apoM/S1P complex on human BAT biology.

Hide

Presenter of 1 Presentation

O020 - Association of the apolipoprotein M and sphingosine-1-phosphate complex with brown adipose tissue after cold exposure in humans (ID 1184)

Session Type
Rapid Fire Session
Session Time
16:00 - 17:30
Date
Mon, 31.05.2021
Room
Hall F
Lecture Time
16:18 - 16:23

Abstract

Background and Aims

The HDL-associated apolipoprotein M (apoM) and its ligand sphingosine-1-phosphate (S1P) may control energy metabolism, as supported by apoM-deficient mice showing a favorable metabolic phenotype with increased triglyceride turnover and protection against obesity-induced insulin resistance. In addition, apoM deficiency is associated with increased vascular permeability and brown adipose tissue (BAT) mass and activity, and these effects are partly mediated by the S1P receptor 1.

Methods

In the current study, we explored the connection between plasma apoM/S1P levels and parameters of BAT as measured via 18F-FDG PET/CT after cold exposure using three different protocols in humans.

Results

Fixed (n=15) vs personalized (n=20) short-term cooling protocols decreased and increased apoM (-8.4%, p=0.032 vs 15.7%, p<0.0005) and S1P (-41.0%, p<0.0005 vs 19.1%, p<0.005) plasma levels, respectively. Long-term cooling (n=44) had no effect on plasma apoM or S1P levels. Plasma apoM and S1P did not correlate significantly to BAT volume and activity in the individual study using fixed or personalized cooling protocols. The short-term studies combined, showed that increased changes in plasma apoM correlated with BAT volume (β:0.39, 95% CI [-0.01-0.78], P=0.054) and metabolic activity (β:0.44, 95% CI [0.06-0.81], P=0.024) after adjusting for study design.

Conclusions

Plasma apoM and S1P levels are altered in response to cold exposure and may be linked to changes in BAT metabolic activity and volume. Our results highlight a possible role of the apoM/S1P complex on human BAT biology.

Hide