306 - Association between non-fasting atherogenic index and anatomical complexity of coronary artery disease in patients with chronic coronary syndrome (ID 751)
Abstract
Background and Aims
Fasting atherogenic index (AI), triglycerides/HDL-C ratio, has been found to be associated with the presence and severity of coronary artery disease(CAD). Recent guidelines have recommended the use of non-fasting lipid assay as being more reflective of atherogenic burden of plasma lipoproteins.We aimed to study the association between non-fasting AI and severity of CAD as assessed by SYNTAX score (SXscore).
Methods
400 patients referred to coronary angiography for suspected stable CAD were included and classified according to SXscore into 3 groups; SXscore < 22 (n=199), SXscore 23-33 (n= 174) and SXscore > 33 (n= 27). Fasting and non-fasting, after a standard meal, lipid assays were done on the day of coronary angiography.
Results
The mean age of patients was 56 ± 9 years with males representing 70.3%. Non-fasting AI was significantly higher than fasting AI (P= 0.008)Both fasting and non-fasting AI were significantly higher in patients with severe CAD (P value for each <0.001). On multivariate logistic regression analysis, non-fasting, but not fasting, AI was significantly associated with SXscore > 22 (for non-fasting AI OD 1.15, 95% CI 1.04 – 1.27, P= 0.006).
Conclusions
Non-fasting, in contrast to fasting, AI is significantly associated with the severity of CAD. Therefore, control of non-fasting AI has to be considered as a therapeutic target among those patients.
