135 - Lipoprotein(a) levels in children with suspected hypercholesterolemia - preliminary data. (ID 1402)
Abstract
Background and Aims
Lipoprotein(a) (Lp(a)) is a particle similar to LDL-cholesterol and has been shown with clinical, Mendelian randomization and genome-wide association studies as an independent causal risk factor for cardiovascular disease and calcific aortic stenosis. We aimed to investigate the different rates of elevated Lp(a) found by screening for Familial Hypercholesterolemia (FH).
Methods
We conducted a retrospective analysis. Children referred to the University Children’s Hospital Ljubljana from the Slovenian Universal screening program for FH with available laboratory levels of total cholesterol (TC) and Lp(a) from the same visit and before treatment initiation were included. As high, a threshold of 500 mg/L has been used for Lp(a).
Results
753 children were included. 442 had negative genetic testing for FH, 44 had variants of unknown significance (VUS), and 267 had confirmed FH. Of those with FH 40 (15,0%) had high Lp(a); of those with VUS 10 (22,7%) had high Lp(a) and of those with negative genetic testing 88 (19,9%) had high Lp(a) (p=0,192; Chi-Squared). We further divided those with negative gentic testing in those with TC above 5,0 mmol/L (331 children) and those bellow (111 children). In those with TC above 5,0 mmol/L, 22,0% had high Lp(a), and in those bellow 13,5% had high Lp(a) (p=0,054; Chi-Squared).
Conclusions
There is no statistically significant difference in the percentage of high Lp(a) with regards to different genetic results for FH. In children with negative genetic testing a trend is seen that in those with higher TC also more high Lp(a) values are present. Further analysis are in progress.
Only SaaG posters should upload a MP3 file in this step.
HideNext ePosters
